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Hiroshi Ashikaga, M.D., Ph.D.

Photo of Dr. Hiroshi Ashikaga, M.D., Ph.D.

Assistant Professor of Medicine


Languages: English, Japanese

Expertise: Arrhythmia, Atrial Fibrillation, Atrial Flutter, Bradycardia, Cardiac Electrophysiology, Cardiology, Cardiovascular Diseases, Cardiovascular MRI, Cardioversion, Catheter Ablation Therapy, Defibrillators, Device Therapy, Heart Block, Heart Disease, Heart Failure, Implantable Cardioverter-Defibrillator Therapy, Irregular Heartbeat, Pacemakers, Palpitations, Paroxysmal Supraventricular Tachycardia, Sudden Cardiac Death, Supraventricular Tachycardia, Syncope, Tachycardias, Tilt Table Test, Ventricular Arrhythmias, Wolff-Parkinson-White (WPW) Syndrome more

Research Interests: Spiral Reentry; Cardiac Biomechanics; Computational Fluid Dynamics; Information Theory; Synchronization; Computational Neuroscience; Geopolitics

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The Johns Hopkins Hospital
Appointment Phone: 443-997-0270

600 N. Wolfe Street
Carnegie 568
Baltimore, MD 21287 map
Phone: 410-502-7861
Fax: 410-502-0231

Johns Hopkins Cardiology - GBMC
Appointment Phone: 443-997-0270

6701 N. Charles Street
Suite 5104
Baltimore, MD 21204 map
Phone: 443-849-8989
Fax: 443-849-8988


Dr. Ashikaga received an M.D. and a Ph.D. degrees from the University of Tokyo, Japan. He completed his clinical training in Internal Medicine at the University of Tokyo and Beth Israel Medical Center, where he served as a Chief Resident. He received his research training in Biomedical Engineering and Cardiovascular MRI at the University of California, San Diego and the National Institutes of Health. He also completed clinical training in Cardiology and Cardiac Electrophysiology at the Johns Hopkins Hospital. He is currently an Assistant Professor of Medicine and Biomedical Engineering at the Johns Hopkins University School of Medicine.

You can find out more information at his website here. more


  • Assistant Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD, University of Tokyo (1996)


  • University of Tokyo / Internal Medicine (1997)
  • Mount Sinai Beth Israel Medical Center / Internal Medicine (2001)


  • University of California San Diego / Cardiology (2002)
  • Johns Hopkins University School of Medicine / Cardiology (2010)
  • Johns Hopkins University School of Medicine / Cardiac Electrophysiology (2012)

Board Certifications

  • American Board of Internal Medicine / Cardiovascular Disease (2010)
  • American Board of Internal Medicine / Clinical Cardiac Electrophysiology (2012)
  • American Board of Internal Medicine / Internal Medicine (2000)

Research & Publications

Lab Website: Ashikaga Lab

Selected Publications


Ashikaga H, Criscione JC, Omens JH, Covell JW, Ingels NB, Jr. Transmural left ventricular mechanics underlying torsional recoil during relaxation. Am J Physiol Heart Circ Physiol 286: H640-H647, 2004 (PMCID: PMC2954110)

Ashikaga H, Omens JH, Ingels NB, Jr, Covell JW. Transmural mechanics at left ventricular epicardial pacing site. Am J Physiol Heart Circ Physiol 286: H2401-H2407, 2004 (PMCID: PMC2965026)

Ashikaga H, Omens JH, Covell JW. Time-dependent remodeling of transmural architecture underlying abnormal ventricular geometry in chronic volume overload heart failure. Am J Physiol Heart Circ Physiol 287: H1994-H2002, 2004 (PMCID: PMC2842928)

Harrington KB, Rodriguez F, Cheng A, Langer F, Ashikaga H, Daughters GT, Criscione JC, Ingels NB, Jr., Miller DC. Direct measurement of transmural laminar architecture in the anterolateral wall of the ovine left ventricle: new implications for wall thickening mechanics. Am J Physiol Heart Circ Physiol 288: H1324-H1330, 2005

Ashikaga H, Covell JW, Omens JH. Diastolic dysfunction in volume overload hypertrophy is associated with abnormal shearing of myolaminar sheets. Am J Physiol Heart Circ Physiol 288: H2603-H2610, 2005 (PMCID: PMC2822838)

Ashikaga H, Mickelsen SR, Ennis DB, Rodriguez I, Kellman P, Wen H, McVeigh ER. Electromechanical analysis of infarct border zone in chronic myocardial infarction. Am J Physiol Heart Circ Physiol 289: H1099-H1105, 2005 (PMCID: PMC2396317)

Mickelsen SR, Ashikaga H, Raval A, DeSilva R, McVeigh ER, Kusumoto FA. Transvenous access to the pericardial space: an approach to epicardial lead implantation for cardiac resynchronization therapy. Pacing Clin Electrophysiol 28: 1018-24, 2005

Moreau-Villger V, Delingette H, Sermesant M, Ashikaga H, McVeigh ER, Ayache N. Building maps of local apparent conductivity of the epicardium with a 2-D electrophysiological model of the heart. IEEE Trans Biomed Eng 53: 1457-66, 2006

Dickfeld T, Kato R, Zviman MM, Nazarian S, Dong J, Ashikaga H, Lardo AC, Berger RD, Calkins H, Halperin HR. Characterization of acute and subacute radiofrequencey ablation lesions with nonenhanced magnetic resonance imaging. Heart Rhythm 4: 208-14, 2007

Ashikaga H, Coppola BA, Hopenfeld B, Leifer ES, McVeigh ER, Omens JH. Transmural dispersion of myofiber mechanics: implications for electrical heterogeneity in vivo. J Am Coll Cardiol 49: 909-16, 2007 (PMCID: PMC2572715)

Ciaccio EJ, Ashikaga H, Kaba RA, Cervantes D, Hopenfeld B, Wit AL, Peters NS, McVeigh E, Garan H, Coromilas J. Model of reentrant ventricular tachycardia based on infarct border zone geometry predicts reentrant circuit features as determined by activation mapping. Heart Rhythm 4: 1034-45, 2007 (PMCID: PMC2626544)

Hopenfeld B, Ashikaga H, McVeigh ER. Geodesic based registration of sensor data and anatomical surface image data. Ann Biomed Eng 35: 1771-81, 2007 (PMCID: PMC2842929)

Ashikaga H, Sasano T, Dong J, Zviman MM, Evers R, Hopenfeld B, Castro V, Helm RH, Dickfeld T, Nazarian S, Donahue JK, Berger RD, Calkins H, Abraham MR, Marbn E, Lardo AC, McVeigh ER, Halperin HR. Magnetic resonance-based anatomical analysis of scar-related ventricular tachycardia: implications for catheter ablation. Circ Res 101: 939-47, 2007 (PMCID: PMC2842927)

Jbsis PD, Ashikaga H, Wen H, Rothstein EC, Horvath KA, McVeigh ER, Balaban RS. Visceral pericardium: macromolecular structure and contribution to passive mechanical properties of the left ventricle. Am J Physiol Heart Circ Physiol 293: H3379-H3387, 2007 (PMCID: PMC2878718)

Ashikaga H, Coppola BA, Yamazaki KG, Villarreal FJ, Omens JH, Covell JW. Changes in regional myocardial volume during the cardiac cycle: implications for transmural blood flow and cardiac structure. Am J Physiol Heart Circ Physiol 295: H610-H618, 2008 (PMCID: PMC2519196)

Sasano T, Abraham MR, Chang KC, Ashikaga H, Mills KJ, Holt DP, Hilton J, Nekolla SG, Dong J, Lardo AC, Helperin H, Dannals RF, Marbn E, Bengel FM. Abnormal sympathetic innervation of viable myocardium and the substrate of ventricular tachycardia after myocardial infarction. J Am Coll Cardiol 51: 2266-75, 2008

Nazarian S, Kolandaivelu A, Zviman MM, Meininger GR, Kato R, Susil RC, Roguin R, Dickfeld TL, Ashikaga H, Calkins H, Berger RD, Blumke DA, Lardo AC, Halperin HR. Feasibility of real-time magnetic resonance imaging for catheter guidance in electrophysiology studies. Circulation 118: 223-9, 2008 (PMCID: PMC2826501)

Ashikaga H, van der Spoel TIG, Coppola BA, Omens JH. Transmural myocardial mechanics during isovolumic contraction. JACC Cardiovasc Imaging 2: 202-211, 2009 (PMCID: PMC2821599)

Hopenfeld B and Ashikaga H. Origin of electrocardiographic U wave: Effects of M cells and dynamic gap junction coupling. Ann Biomed Eng 38: 1060-70, 2010 (PMCID: PMC2842929)

Ashikaga H, Leclercq C, Wang J, Kass DA, McVeigh ER. Hemodynamic improvement in cardiac resynchronization does not require improvement in left ventricular rotation mechanics: three-dimensional tagged MRI analysis. Circ Cardiovasc Img 3: 456-63, 2010 (PMCID: PMC2965024)

Estner HL, Zviman MM, Herzka D, Miller F, Castro V, Nazarian S, Ashikaga H, Dori Y, Berger RD, Calkins H, Lardo AC, Halperin HR. The critical isthmus sites of ischemic ventricular tachycardia are in zones of tissue heterogeneity, visualized by magnetic resonance imaging. Heart Rhythm 8: 1942-9, 2011

Ashikaga H, Omens JH. In vivo validation of longitudinal-circumferential area change ratio to estimate myofiber shortening in the heart. IEEE Trans Biomed Eng 59: 1391-7, 2012



Kawada S, Suzuki Y, Hinohara S, Koide S, Ono Y, Ashikaga H. Cancer screening with PET: advantages and limitations. Rinsho Byori 55: 656-67, 2007 (Japanese)

Koide S, Ashikaga H, Suzuki Y, Kawada S. Screening of coronary artery disease using myocardial perfusion positron emission tomography in asymptomatic population. Vita Medical Science Review 24: 369-76, 2007 (Japanese)

Ashikaga H. Management of ventricular tachycardia. Resident Note, Sep 2011 (Japanese)

Ashikaga H, Kolandaivelu A, Tandri H, Nazarian S, Halperin HR. Cardiac Magnetic Resonance Imaging (MRI): Diagnostic and prognostic value for the patient with cardiac arrhythmias. Heart Rhythm, In Press

Ashikaga H. Management of arrhythmia after acute coronary syndrome. Intensivist (Japanese), In Press



Ashikaga H and Marine JE. Prevention of atrial fibrillation: Another good reason to recommend statins for women? Heart 95: 693-4, 2009

Ashikaga H, Blumenthal RS, Jones SR. Utility of ezetimibe. Am J Cardiol 103: 1321-2, 2009



Ashikaga H, Abreu R, Schneider R. Propranolol administration in a patient with thyroid storm. Ann Intern Med 132:681-2, 2000

Ashikaga H, McVeigh ER, Omens JH. Reply: On the mechanisms of transmural dispersion of myocardial mechanics. J Am Coll Cardiol 50: 650, 2007



Ashikaga H, Ben-Yehuda O, Chien KR. Biotechnology and cardiovascular medicine: Recombinant protein therapy. In Molecular Basis of Cardiovascular Disease, 2/e, A Companion to Braunwalds Heart Disease, Edited by Chien KR. Philadelphia, W.B. Saunders Company. Chapter 1, p 1-15, 2004

Ashikaga H, Ben-Yehuda O, Chien KR. Coronary restenosis. In Molecular Basis of Cardiovascular Disease, 2/e, A Companion to Braunwalds Heart Disease, Edited by Chien KR. Philadelphia, W.B. Saunders Company. Chapter 25, p 455-469, 2004

Ashikaga H and Chien KR. Blood coagulation and atherothrombosis. In Molecular Basis of Cardiovascular Disease, 2/e, A Companion to Braunwalds Heart Disease, Edited by Chien KR. Philadelphia, W.B. Saunders Company. Chapter 28, p 498-518, 2004

Ashikaga H and Villarreal FJ. Prospects for gene therapy for the fibrosed heart: Targeting regulators of extracellular matrix turnover. In Interstitial Fibrosis In Heart Failure, Edited by Villarreal FJ. New York, Springer Science+Business Media, Inc. Chapter 17, p 343-354, 2005

Ashikaga H and McVeigh ER. Imaging of myocardial mechanics. In Novel Techniques for Imaging the Heart: Cardiac MR and CT, Edited by Di Carli MF and Kwong RY. American Heart Association. Oxford, Blackwell Publishing. Chapter 21, p 328-335, 2008

Ashikaga H. Myofiber orientation and left ventricular mechanics. In Diastology, Edited by Ohki T and Takenaka K. Tokyo, Japan. Bunkodo Publishing. Chapter 3, p 15-22, 2010 (Japanese)

Ashikaga H, Kolandaivelu A, Tandri H, Nazarian S, Halperin HR. CT and MR Imaging for electrophysiology. In Cardiac Electrophysiology: From Cell to Bedside, 6/e, Edited by Zipes DP and Jalife J. In Press

Activities & Honors


  • Travel Award, American College of Cardiology , 2003
  • Travel Award, American Federation for Medical Research , 2003
  • Postdoctoral Fellowship, American Heart Association, 2002
  • Melvin Judkins Young Clinical Investigator Award - Finalist, American Heart Association, 2011
  • Young Investigator Award - Winner, Asia-Pacific Heart Rhythm Society, 2011
  • Fellowship Award, Astellas Foundation , 2006
  • Young Investigator Award - Finalist, Heart Rhythm Society, 2006
  • Howard S. Silverman Award, Johns Hopkins University School of Medicine, 2010
  • Elite Reviewer, Journal of the American College of Cardiology, 2006


  • American College of Cardiology
  • American Heart Association
  • Heart Rhythm Society
  • Society for Industrial and Applied Mathematics
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