Research Summary
Dr. Kulkarni conducts research that explores the origin and development of the enteric nervous system. He seeks to better understand the pathways that can be manipulated to create cell and matrix-based transplantational and regenerative therapies of enteric neuronal disorders.
Selected Publications
Becker L, Peterson J, Kulkarni S, Pasricha PJ. "Ex vivo neurogenesis within enteric ganglia occurs in a PTEN dependent manner." PLoS One. 2013;8(3):e59452. doi: 10.1371/journal.pone.0059452. Epub 2013 Mar 19.
Becker L, Kulkarni S, Tiwari G, Micci MA, Pasricha PJ. "Divergent fate and origin of neurosphere-like bodies from different layers of the gut." Am J Physiol Gastrointest Liver Physiol. 2012 May 1;302(9):G958-6.
Rothenberg ME, Nusse Y, Kalisky T, Lee JJ, Dalerba P, Scheeren F, Lobo N, Kulkarni S, Sim S, Qian D, Beachy PA, Pasricha PJ, Quake SR, Clarke MF. "Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice." Gastroenterology. 2012 May;142(5):1195-1205.e6.
Kulkarni S, Zou B, Hanson J, Micci MA, Tiwari G, Becker L, Kaiser M, Xie XS, Pasricha PJ. "Gut-derived factors promote neurogenesis of CNS-neural stem cells and nudge their differentiation to an enteric-like neuronal phenotype." Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G644-55. doi: 10.1152/ajpgi.00123.2011.
Kulkarni S, Becker L, Pasricha PJ. "Stem cell transplantation in neurodegenerative disorders of the gastrointestinal tract: future or fiction?" Gut. 2012 Apr;61(4):613-21. doi: 10.1136/gut.2010.235614. Epub 2011 Aug 4. Review.
Abi-Rached L, Jobin MJ, Kulkarni S, McWhinnie A, Dalva K, Gragert L, Babrzadeh F, Gharizadeh B, Luo M, Plummer FA, Kimani J, Carrington M, Middleton D, Rajalingam R, Beksac M, Marsh SG, Maiers M, Guethlein LA, Tavoularis S, Little AM, Green RE, Norman PJ, Parham P. "The shaping of modern human immune systems by multiregional admixture with archaic humans." Science. 2011 Oct 7;334(6052):89-94. doi: 10.1126/science.1209202.
