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Carlo Colantuoni, Ph.D.

Photo of Dr. Carlo Colantuoni, Ph.D.

Assistant Professor of Neurology

Background

Dr. Colantuoni is an assistant professor of neurology and neuroscience. He earned his A.B. from Princeton University in 1996 and his Ph.D. from Johns Hopkins School of Medicine in 2002. At the Lieber Institute for Brain Development, Dr. Colantuoni and his colleagues elucidate fundamental mechanisms in human brain development using the Institute's postmortem human brain collection and human pluripotent cell resources.

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Titles

  • Assistant Professor of Neurology
  • Assistant Professor of Neuroscience

Education

Degrees

  • A.B., Princeton University (New Jersey) (1996)
  • Ph.D., Johns Hopkins University School of Medicine (Maryland) (2002)

Research & Publications

Research Summary

To elucidate fundamental mechanisms in human brain development, I leverage two unique assets at the Lieber Institute (in combination with other diverse biological data resources): the postmortem human brain collection and human pluripotent cell resources.

Defining a common transcriptional landscape across these systems will enable us to develop meaningful, mechanistic connections between the in vivo observations and the in vitro experimental systems.

The eventual goal is to design experiments in the precisely controlled in vitro differentiation systems which will, in effect, allow us to probe the in vivo systems of human brain development.

Selected Publications

Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory. Haberman RP, Colantuoni C, Koh MT, Gallagher M. PLoS One. 2013 Dec 13;8(12):e83674. doi: 10.1371/journal.pone.0083674. eCollection 2013. PMID: 24349543

Pattern identification in time-course gene expression data with the CoGAPS matrix factorization. Fertig EJ, Stein-O'Brien G, Jaffe A, Colantuoni C. Methods Mol Biol. 2014;1101:87-112. doi: 10.1007/978-1-62703-721-1_6. PMID: 24233779

Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: utility and limitation of the surrogate tissues in research for brain disorders. Horiuchi Y, Kano S, Ishizuka K, Cascella NG, Ishii S, Talbot CC Jr, Jaffe AE, Okano H, Pevsner J, Colantuoni C, Sawa A. Neurosci Res. 2013 Dec;77(4):247-50. doi: 10.1016/j.neures.2013.09.010. Epub 2013 Oct 11. PMID: 24120685

MicroRNA-382 expression is elevated in the olfactory neuroepithelium of schizophrenia patients. Mor E, Kano S, Colantuoni C, Sawa A, Navon R, Shomron N. Neurobiol Dis. 2013 Jul;55:1-10. doi: 10.1016/j.nbd.2013.03.011. Epub 2013 Mar 29. PMID: 23542694

DNA methylation signatures in development and aging of the human prefrontal cortex. Numata S, Ye T, Hyde TM, Guitart-Navarro X, Tao R, Wininger M, Colantuoni C, Weinberger DR, Kleinman JE, Lipska BK. Am J Hum Genet. 2012 Feb 10;90(2):260-72. doi: 10.1016/j.ajhg.2011.12.020. Epub 2012 Feb 2. Erratum in: Am J Hum Genet. 2012 Oct 5;91(4):765. PMID: 22305529

Activities & Honors

Honors

  • Elected, Sigma Xi Scientific Research Society, 1996
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