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Dimitrios G. Avramopoulos, M.D., Ph.D.
Associate Professor of Psychiatry and Behavioral Sciences
Research Interests: Genetics of Complex Disorders; Genetics of Psychiatric disorders (bipolar, Alzheimer''s, Schizophrenia); Genetic linkage mapping; Genetic association mapping; Positional cloning; Gene expression analysis ...read more
Dr. Dimitrios Avramopoulos is an associate professor of psychiatry and behavioral sciences in the McKusick-Nathans Institute of Genetic Medicine. He holds a medical degree from the National and Kapodistrian University of Athens and a doctorate of philosophy in human genetics from the University of Crete School of Medicine.
Dr. Avramopoulos completed a fellowship in psychiatry and pediatric genetics at the Johns Hopkins University School of Medicine before joining the Johns Hopkins faculty in 2002.
Dr. Avramopoulos’s research focuses on the complex genetics of disorders like schizophrenia and Alzheimer’s disease. His interest is in understanding how genetic variants increase disease risk and identify the opportunities for intervention.
Dr. Avramopoulos sits on the editorial board of the Frontiers in Behavioral and Psychiatric Genetics journal and Molecular Neuropsychiatry. He has editorial responsibilities at more than 20 peer-review journals, including Human Molecular Genetics, the American Journal of Psychiatry, JAMA Psychiatry and the British Medical Journal.
Dr. Avramopoulos is a member of the International Society of Neuropsychiatric Genetics, the American Society of Human Genetics, the American Association for the Advancement of Science and the Alzheimer’s Association International Society to Advance Alzheimer Research and Treatment.
Dr. Avramopoulos has been awarder multiple grants for his work from the NIH and other Foundations.
- Associate Professor of Psychiatry and Behavioral Sciences
Departments / Divisions
Centers & Institutes
- M.D., University Athens - Fac Medicine - School of Hlth Sci - Nat'l and Kapodistrian - Athens (Greece) (1990)
University of Mental Health and Research Institute, Athens, Greece, 2001; Military Service, Athens, Greece, 1996
Research & Publications
Selected PublicationsView all on Pubmed
Hatzimanolis A, McGrath JA, Wang R, Li T, Wong PC, Nestadt G, Wolyniec PS, Valle D, Pulver AE, Avramopoulos D. Multiple variants aggregate in the neuregulin signaling pathway in a subset of schizophrenia patients. Transl Psychiatry. 2013 May 28;3:e264. doi: 10.1038/tp.2013.33. PMID: 23715299
Avramopoulos D, Pearce BD, McGrath J, Wolyniec P, Wang R, Eckart N, Hatzimanolis A, Goes FS, Nestadt G, Mulle J, Coneely K, Hopkins M, Ruczinski I, Yolken R, Pulver AE. Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation. PLoS One. 2015 Mar 17;10(3):e0116696. doi: 10.1371/journal.pone.0116696. eCollection 2015. PMID: 25781172
Hatzimanolis A, Bhatnagar P, Moes A, Wang R, Roussos P, Bitsios P, Stefanis CN, Pulver AE, Arking DE, Smyrnis N, Stefanis NC, Avramopoulos D. Common genetic variation and schizophrenia polygenic risk influence neurocognitive performance in young adulthood. Am J Med Genet B Neuropsychiatr Genet. 2015 Jul;168B(5):392-401. doi: 10.1002/ajmg.b.32323. Epub 2015 May 12. PMID: 25963331
Eckart N, Song Q, Yang R, Wang R, Zhu H, McCallion AS, Avramopoulos D. Functional Characterization of Schizophrenia-Associated Variation in CACNA1C. PLoS One. 2016 Jun 8;11(6):e0157086. doi: 10.1371/journal.pone.0157086. eCollection 2016. PMID: 27276213
Pham X, Song G, Lao S, Goff L, Zhu H, Valle D, Avramopoulos D. The DPYSL2 gene connects mTOR and schizophrenia. Transl Psychiatry. 2016 Nov 1;6(11):e933. doi: 10.1038/tp.2016.204. PMID: 27801893
Academic Affiliations & Courses
Graduate Program Affiliation
- Advanced Topics in Human Genetics course, a required course for 1st year graduate students in human genetics. I teach a "hands on" class on genetic association where the students perform all the steps in the analysis of a genome wide association study.
- Genetics Journal Club: The IGM journal club is part of the graduate students’ training. Faculty members and students present scientific papers providing comprehensive scientific background and critical comments on each presented paper.
Courses and Syllabi
Principles of Genetics course
A required course for 1st year graduate students in Human Genetics and MBG. I am teaching Genetic mapping in humans
Introduction to Computational Genetics
An 8-week course 2 - 1½ hours sessions per week. I am co-directing and sharing teaching responsibilities with Dr. Dan Arking.
Activities & Honors
- Neurosciences Education and Research Foundation award, 2005
- NARSAD Young investigator Award, 2005
- American Association for the Advancement of Science
- American Society of Human Genetic
- International Society of Neuropsychiatric Genetics