Dr. Walker’s primary area of research focuses on understanding the mechanistic role of abnormal immune functioning and inflammation in Alzheimer’s disease, late-life cognitive decline, and physical frailty. He is currently using proteomics, exosomes, and neuroimaging to investigate the link between chronic systemic inflammation, neuroinflammation, and neurologic endpoints using data from ongoing cohort such as the Atherosclerosis Risk in Communities (ARIC) Study and BIOCARD cohort. He is also investigating the mechanisms underlying cognitive decline resulting from critical illness, major infection, and iatrogenic factors associated with hospitalization. Additionally, his work examines the association of middle- and late-life vascular risk factors with dementia and structural brain changes.
Dr. Walker received his bachelor’s degrees in psychology and brain sciences and cognitive science from Johns Hopkins University. He received his Ph.D. in clinical psychology from St. John's University. He completed his pre-doctoral internship in clinical neuropsychology at the University of California San Diego / VA San Diego Healthcare System before beginning his postdoctoral fellowship at Johns Hopkins School of Medicine in age-related cognitive disorders.