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Demetrios N. Simopoulos, M.D.

Demetrios Nicholas Simopoulos, M.D.

Photo of Dr. Demetrios N. Simopoulos, M.D.
4.7 out of 5
132 Ratings
| 1 Comment
  • Assistant Professor of Urology


Active Surveillance of Prostate Cancer, Prostate Cancer, Urology

Research Interests

Imaging technology including MRI; PSMA-PET/CT and Fusion Biopsy for early stage prostate cancer diagnosis and treatment; hemi-gland cryoablation to treat prostate cancer more

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The Johns Hopkins Hospital

Appointment Phone: 410-955-6100
600 N. Wolfe Street
Baltimore, MD 21287 map

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-955-6100
10803 Falls Road
Pavilion III, Suite 3300
Lutherville, MD 21093 map
Phone: 410-616-7600


Dr. Simopoulos is a board certified urologist with fellowship training in urologic oncology focusing on MRI-guided biopsy, active surveillance and focal therapy to treat and diagnose prostate cancer. Dr. Simopoulos believes in prioritizing the patient’s well-being throughout their treatment journey. He strives to deliver the most effective and least invasive treatment for men with prostate cancer.

Mirroring his clinical practice, Dr. Simopoulos’ research interests are prostate cancer diagnosis and treatment for early stage prostate cancer, using imaging technology including MRI, PSMA-PET/CT and Fusion Biopsy. He served as a co-investigator on the efficacy of hemi-gland cryoablation to treat prostate cancer and is experienced in the use of high-intensity focused ultrasound (HIFU) to ablate prostate tissue. Future interests include laser ablation techniques to treat prostate cancer focally. more


  • Assistant Professor of Urology

Departments / Divisions



  • MD, Tulane University School of Medicine (1995)


  • Mayo Clinic / Urology (2001)


  • Ronald Reagan UCLA Medical Center / Urologic Oncology (2018)

Board Certifications

  • American Board of Urology / Urology (2003)

Research & Publications

Selected Publications

Elkhoury FF, Simopoulos DN, Marks LS: MR-Guided Biopsy and Focal Therapy: The New Era of Prostate Cancer Management. Current Opinion in Urology 2018; 28(2): 93-101.

*Elkhoury FF, *Simopoulos DN, Marks LS: Targeted Prostate Biopsy in the Era of Active Surveillance. Urology 2018; 112(2): 12-19. *Co-First Authors.

Chang E, Jones TA, Natarajan S, Sharma D, Simopoulos DN, Margolis DJ, Huang J, Dorey FJ, Marks LS: Value of tracking biopsy in men undergoing active surveillance of prostate cancer. Journal of Urology 2018; 199(1): 98-105.

Simopoulos DN, Gibbons SJ, Malysz J, Szurszewski JH, Farrugia G, Ritman EL, Moreland RB, Nehra A: Corporeal structural and vascular micro architecture with X-ray micro computerized tomography in normal and diabetic rabbits: histopathological correlation. Journal of Urology 2001; 165(5): 1776-1782.

Simopoulos DN, Ratliff J, Elahi P, Brown M, Waters M, McMahon FG: Cholesterol levels in 1,084 healthy New Orleans males. Journal of the Louisiana State Medical Society 1993; 145: 347-351.

Activities & Honors


  • American Urological Association
  • American Urological Association Western Section
  • American Association of Clinical Urologists

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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