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Mohan Kumar Krishnan, M.S., Ph.D.

Photo of Dr. Mohan Kumar Krishnan, M.S., Ph.D.
  • Assistant Professor of Pediatrics

Research Interests

Neonatal anemia; murine RBC-transfusion; Necrotizing Enterocolitis; Retinopathy of Prematurity; retinal inflammation; Leukocyte Biology and functions

Background

Dr. Krishnan, Assistant Professor, received his Ph.D. in Biochemistry-Biotechnology from the University of Madras in 2008.  He completed his postdoctoral fellowship in the Department of Pediatrics at the University of Alabama at Birmingham and Department of Pediatrics, University of Illinois at Chicago. After he worked as Research Associate in Department of Pediatrics at the University of South Florida, Dr. Krishnan joined the faculty at JHU in May 2018. His lab investigates the pathophysiology of Retinopathy of Prematurity (ROP) in premature infants who are at high risk of anemia.  Dr. Krishnan’s major research interests are in gaining a greater understanding of the mechanisms of retinal inflammation associated ROP during anemia and/or RBC-transfusion, with the ultimate goal of developing new therapeutic strategies and treatment for pathological retinopathies.  He is dedicated to understanding the role of leukocytes in the neonatal retina and investigating their inflammatory phenotype, function during anemia and/or RBC-transfusion. 

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Titles

  • Assistant Professor of Pediatrics

Departments / Divisions

Education

Degrees

  • Ph.D., University of Madras (India) (2008)
  • M.S., University of Madras (India) (2001)
  • B.S., University of Madras (India) (1997)

Research & Publications

Research Summary

Mohan Krishnan’s research interests focus on the inflammatory mechanisms of neonatal necrotizing enterocolitis (NEC), specifically on red blood cell (RBC) transfusion-associated NEC. Dr. Krishnan is currently the PI (interim) of two NIH-R01 projects: (1) Red Cell Transfusion-associated Necrotizing Enterocolitis in Premature Infants and (2) Effect of Platelet Transfusions on Neonatal Intestinal Injury. Dr. Krishnan is interested in the role of leukocytes in NEC pathogenesis, developed a preclinical mouse model of RBC transfusion-associated NEC and recently published in Nature Communications. This novel model of transfusion-associated NEC is the first preclinical model of transfusion effects in the neonatal intestine and has been awarded a provisional patent. He laid the groundwork for these animal models to understand the mechanism(s) by which bowel injury occurs during NEC, a critical step in the development of novel anti-inflammatory therapies that can prevent/ameliorate tissue damage in NEC. By focusing on red blood cell biology and transfusion medicine, he increasingly appreciates shared molecular mechanisms driving transfusion-associated adverse effects such as retinopathy of prematurity (ROP), NEC, intra-ventricular hemorrhage, and bronchopulmonary dysplasia. Currently, he is studying the mechanism of how RBC transfusion exacerbates the severity of ROP in anemic mouse pups by activation of leukocytes that induced prolonged angiogenesis. He has 20 publications to his credit and has several major manuscripts currently under review.

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