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Akhil Maheshwari, M.B.B.S.

Photo of Dr. Akhil Maheshwari, M.B.B.S.
  • Director, Division of Neonatology
  • Professor of Pediatrics

Expertise

Neonatal-Perinatal Medicine

Research Interests

Inflammatory Gut Injury In Neonatal Necrotizing Enterocolitis (NEC); Host-Microbial Interaction; Leukocyte Trafficking; Cytokines; Tight Junctions; Macrophage Function; Protective Factors In Human Milk; Neonatal Intestinal Injury; Neonatal Liver Conditions ...read more

Locations

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-5259
1800 Orleans St.
The Charlotte R. Bloomberg Children's Center Building, Room 8530
Baltimore, MD 21287 map
Phone: 410-955-5259 | Fax: 410-955-0298

Background

Dr. Akhil Maheshwari is a neonatal-perinatal specialist in Baltimore, caring for patients with neonatal intestinal and liver conditions. Dr. Maheshwari is the director of the Division of Neonatology at the Johns Hopkins School of Medicine.

Dr. Maheshwari received his M.B.B.S. at Banaras Hindu University in India. 

His research interests include neonatal intestinal injury and liver disease.

Dr. Maheshwari serves on the Communications Committee for the American Pediatric Society and as convener for the NEC Focus Group of the Pediatric Academic Societies Meetings. He has been recognized by the American Gastroenterological Association with a Research Scholar Award and is a Pamela and Leslie Muma Chair Honoree and a member of the Alpha Omega Alpha Honor Medical Society. He is a member of the American Academy of Pediatrics, the American Pediatric Society, the NEC Society and the Society for Pediatric Research.

...read more

Titles

  • Director, Division of Neonatology
  • Vice-Chair (Integration), Department of Pediatrics
  • Josephine S. Sutland Professor of Newborn Medicine
  • Professor of Pediatrics

Departments / Divisions

Centers & Institutes

Education

Degrees

  • M.B.B.S., Banaras Hindu University (India) (1997)

Research & Publications

Research Summary

Akhil Maheshwari is an internationally recognized expert in neonatal intestinal injury and associated innate immune response. His major scientific contributions include mechanisms underlying the unique susceptibility of premature neonates to intestinal injury, role of macrophages in NEC, role of RBC transfusions in neonatal intestinal injury, and unique developmental roles of inflammatory mediators. His laboratory has developed several preclinical and clinical models to investigate the mechanisms of NEC. He has been continuously funded by the NIH through the R01 mechanism since 2007, and currently has two major lines of investigation, each supported through the R01 mechanism, focused on RBC transfusions and platelet transfusions in NEC, respectively. Dr. Maheshwari has authored or co-authored more than 100 manuscripts and book chapters, edited two textbooks of neonatology, and has been awarded several patents for novel anti-inflammatory agents. He serves on the editorial boards of several professional journals and is an active reviewer for many others. He sits on grant review committees at the NIH, Canadian Institutes for Health Research, American Heart Association, and on several similar committees in Europe and Asia.

Selected Publications

View all on Pubmed

Ho TTB, Groer MW, Kane B, Yee AL, Torres BA, Gilbert JA, Maheshwari A. Dichotomous development of the gut microbiome in preterm infants. Microbiome. 2018; 6(1):157. PMID: 30208950, PMCID: PMC6136210

Maheshwari A, Kelly DR, Nicola T, Ambalavanan N, Jain SK, Murphy-Ullrich J, Athar M, Shimamura M, Bhandari V, Aprahamian C, Dimmitt RA, Serra R, Ohls RK. TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine. Gastroenterology. 2011; 140(1):242-53. NIHMSID: NIHMS239996; PMID: 20875417, PMCID: PMC3008335

Clinics in Perinatology, Special edition on Necrotizing Enterocolitis. Denning PW, Maheshwari A (eds); Mar 2013;40 (1)

Hematology, Immunology, and Infectious Disease: Neonatology Questions and Controversies. Ohls RK, Maheshwari A (eds). Philadelphia, Elsevier, 2nd Ed. 12 Mar 2012; ISBN-13: 978-1437726626

Hematology, Immunology & Genetics: Neonatology Questions and Controversies. Ohls RK, Maheshwari A, Christensen RD (Eds.). Philadelphia, Elsevier, 3rd Ed. 4 Sep 2018; ISBN-18: 978-0323544009; eBook ISBN: 978-0323568470; 978-0323568487

Activities & Honors

Honors

  • Pamela and Leslie Muma Chair Honoree
  • Alpha Omega Alpha Honor Medical Society
  • Research Award, University of Illinois
  • Research Scholar Award, American Gastroenterological Association

Memberships

  • American Academy of Pediatrics
  • American Pediatric Society
  • NEC Society
  • Society for Pediatric Research

Professional Activities

  • Communications Committee, American Pediatric Society
  • Convener, NEC Focus Group, Pediatric Academic Societies Meetings

Videos & Media

Recent News Articles and Media Coverage

Of Mice and Babies: New Animal Model Links Blood Transfusions to Dangerous Digestive Disease in Preemies, Johns Hopkins Institute for Cinical and Translastional Research (August 13, 2019)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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