Jennifer Erwin studies how environmental and genetic variations affect the human brain in health and disease. During her postdoctoral research in the laboratory of Fred H Gage, she discovered that the human brain exhibits extensive genetic variability. She developed single-cell sequencing strategies to define the mutational landscape of somatic brain retrotransposition in human stem cell models, human post-mortem tissue and mouse. As a principal investigator at the Lieber Institute for Brain Development, her research group uses a hybrid of human stem cell models, post-mortem tissue and computational approaches to interrogate the contribution of epigenetic and somatic mosaicism to brain diseases. She obtained a BSc in Biology from the Massachusetts Institute of Technology where she trained in the laboratory of Dr. Rudolf Jaenisch and Dr. Kevin Eggan. During her PhD at Harvard University in the laboratory of Dr. Jeannie T. Lee, she elucidated mechanisms of non-coding RNA mediated epigenetic regulation in stem cells.