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Chan Hyun Na, M.S., Ph.D.

Photo of Dr. Chan Hyun Na, M.S., Ph.D.

Assistant Professor of Neurology

Background

Chan-Hyun Na, Ph.D. has extensive expertise in proteomics including LC-MS/MS-based mass spectrometry, imaging mass spectrometry, bioinformatics, and computer programming. In addition, he has been trained in neurodegenerative diseases and molecular biology. He obtained his Ph.D. from POSTECH, South Korea and then he moved to Konkuk University, South Korea where he established and optimized imaging mass spectrometry for biomarker discovery from renal cell carcinoma tissues. Subsequently, he joined Emory University, where he developed various proteomics methods using Fourier Transform-based mass spectrometry to study ubiquitin biology. After joining Johns Hopkins University, he has been involved in applying proteomics technologies for discovering biomarkers and disease mechanisms of various neurodegenerative diseases, elucidating novel protein-protein interactions in a variety of contexts, identifying cryptic open reading frames encoded in the human genome and identifying long-lived synaptic proteins by measuring turnover of synaptosome proteins. In addition, he served as research director of the Center for Proteomics Discovery, Johns Hopkins University School of Medicine completing over 120 proteomics projects successfully. He is currently an Assistant Professor in the Department of Neurology and the Institute for Cell Engineering.

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Titles

  • Assistant Professor of Neurology

Departments / Divisions

Education

Degrees

  • B.S., Soonchunhyang University (South Korea) (1999)
  • M.S., Pohang University of Science and Technology (Korea) (2001)
  • Ph.D., Pohang University of Science and Technology (Korea) (2007)

Research & Publications

Lab

Dr. Na’s lab is applying proteomics technologies for diverse biological questions including discovering biomarkers and disease mechanisms of various neurodegenerative diseases and studying cryptic open reading frames in the context of their involvement in various diseases.

Selected Publications

View all on Pubmed

Heo S.*, Diering G. H.*, Na C. H.*, Nirujogi R. S., Bachman J. L., Pandey A., and Huganir R. L. (2018) Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover. Proc Natl Acad Sci USA 115(16):E3827-E3836. *These authors contributed equally

Na C. H.*, Barbhuiya M. A., Kim M. S., Verbruggen S., Eacker S. M., Pletnikova O., Troncoso J. C., Halushka M. K., Menschaert G., Overall C. M. and Pandey A.* (2018) Discovery of noncanonical translation initiation sites through mass spectrometric analysis of protein N termini. Genome Research 28(1), 25-36 *Co-corresponding authors

Bettridge J., Na C. H., Pandey A. P. and Desiderio S. (2017) H3K4Me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of V(D)J recombinase. Proc Natl Acad Sci USA 114(8),1904-1909

Na C. H., Hong J. H., Kim W. S., Shanta S. R., Bang J. Y., Park D., Kim H. K., and Kim K. P. (2015) Identification of Protein Markers Specific for Papillary Renal Cell Carcinoma Using Imaging Mass Spectrometry. Mol Cells 38(7), 624-629

Na C. H., Jones D. R., Yang Y., Wang X., Xu Y., and Peng J. (2012) Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. J Proteome Res 11, 4722-4732.

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