As a researcher, my research has focused on the application of translational approaches to understand and improve therapeutic outcomes for children and adolescents with neuropsychiatric disorders--focusing on OCD, anxiety disorders, hair pulling disorder, and Tourette Disorder. To achieve these goals, my research synergizes neurobiological research findings and clinical experience to develop targeted, treatment-oriented research questions. These questions are examined by integrating information across psychophysiological outcomes, subjective self-reports, validated rating scales, and behavioral observations. Through a better understanding of the nuanced processes implicated in childhood neuropsychiatric disorders across multiple determinants, impaired mechanisms can be identified and existing treatments tailored to provide more precise, personalized, and effective interventions. This is crucial to diminish morbidity associated with these conditions across the lifespan, and inform eventual prevention efforts.
obsessive-compulsive disorder (OCD), anxiety disorders, hair pulling disorder, and Tourette Disorder; cognitive behavior therapy, habit reversal training; d-cycloserine; extinction learning
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McGuire, J. F., Wu, M. S., Piacentini, J., McCracken, J. T., & Storch, E. A. (2017). A Meta-Analysis of D-Cycloserine in Exposure-Based Treatment: Moderators of Treatment Efficacy, Response, and Diagnostic Remission. The Journal of clinical psychiatry, 78(2), 196-206.
McGuire, J. F., Orr, S. P., Essoe, J. K. Y., McCracken, J. T., Storch, E. A., & Piacentini, J. (2016). Extinction learning in childhood anxiety disorders, obsessive compulsive disorder and post-traumatic stress disorder: implications for treatment. Expert review of neurotherapeutics, 16(10), 1155-1174.
McGuire, J. F., Orr, S. P., Wu, M. S., Lewin, A. B., Small, B. J., Phares, V., ... & Storch, E. A. (2016). Fear Conditionin and Extinction In Youth with Obsessive-Compulsive Disorder. Depression and anxiety, 33(3), 229-237.
McGuire, J. F. (2016). Behavior Therapy for Youth With Tourette Disorder. Journal of clinical psychology, 72(11), 1191-1199.
McGuire, J. F., Arnold, E., Park, J. M., Nadeau, J. M., Lewin, A. B., Murphy, T. K., & Storch, E. A. (2015). Living with tics: reduced impairment and improved quality of life for youth with chronic tic disorders. Psychiatry research, 225(3), 571-579.