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Philip William Jordan, Ph.D.

Headshot of Philip William Jordan
  • Joint Appointment in Cell Biology

Research Interests

Stem Cells; Gametogenesis; Genome Integrity; Neurodevelopment ...read more

Background

Philip Jordan is an Associate Professor in the Biochemistry and Molecular Biology Department, Johns Hopkins University Bloomberg School of Public Health in Baltimore, Maryland. He received his undergraduate with honors degree from Flinders University of South Australia, and a Ph.D. from the University of Edinburgh, UK. During Dr. Jordan’s training he developed a keen focus on research that encompasses maintenance of genome integrity and cell cycle progression. He was a post-doctoral fellow (2007 to 2010) in Eva Hoffman’s lab at the Genome Damage and Stability Center, University of Sussex, UK. He then moved to Mary Ann Handel’s lab at the Jackson Laboratory, Maine, USA, as a Fulbright Distinguished Scholar. Dr. Jordan received a K99 Pathway to Independence Award from the NIH, and in 2013 he was recruited as faculty at Johns Hopkins University. His research program encompasses using mouse and human stem cells and germ cells to discover the molecular processes that ensure genome stability during gametogenesis and early development.

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Titles

  • Joint Appointment in Cell Biology
  • Joint Appointment in Oncology
  • Joint Appointment in Urology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • Ph.D.; University of Edinburgh (United Kingdom) (2006)

Research & Publications

Research Summary

Our research focuses on understanding the molecular mechanisms regulating DNA repair, chromosome segregation and cell cycle progression. Our lab studies the importance of Structural Maintenance of Chromosomes (SMC) complexes and cell cycle kinases, particularly Polo-like (PLK) kinases and Aurora kinases. We use mouse as a model organism to study consequences of gene mutation and chromosome missegregation, which give rise to physical and cognitive developmental defects, infertility, and cancer predisposition. We also use mouse and human pluripotent stem cells to help define the function of these proteins within essential molecular pathways of the cell. Our current research encompasses the following:

  1. Gametogenesis (spermatogenesis and oogenesis)
  2. Pluripotent stem cell genome maintenance
  3. Neurodevelopment

Lab

Lab Website: Jordan Lab

Technology Expertise Keywords

Meiosis; Structural maintenance of chromosomes; SMC5; SMC6;Polo-like kinase; PLK; Aurora kinase; AURK; Chromosome segregation; recombination; DNA repair; cell cycle; gametogenesis; embryonic stem cells; neural stem cells; neurodevelopment

Selected Publications

View all on PubMed

Alisa Atkins, Michelle J. Xu, Maggie Li, Nathaniel P. Rogers, Marina V. Pryzhkova, Philip W. Jordan (2020) SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. eLife. e61171

Wellard S, Schindler K and Jordan PW (2020) Aurora B and Aurora C kinases regulate synaptonemal complex disassembly in male mice and humans. J. Cell Sci. 133: jcs248831

Pryzhkova MP, Xu M and Jordan PW. (2020) Adaptation of the AID system for stem cell and transgenic mouse research. Stem Cell Research. (49): 102078.

Hwang G, O’Brien M, Sun F, Eppig J, Handel MA, Jordan PW (2017) SMC5/6 is required for the formation of segregation-competent bivalent chromosomes during meiosis I in mouse oocytes. Development. 144: 1648-1660

Hopkins J, Hwang G, Jacob J, Sapp N, Bedigian R, Oka K, Overbeek P, Murray S and Jordan P. (2014) Meiosis-specific cohesin component, Stag3 is essential for mediating recombination and synapsis between homologous chromosomes and maintaining sister chromatid cohesion. PLoS Genetics; 10 (7) e1004413

Contact for Research Inquiries

Johns Hopkins University Bloomberg School of Public Health
615 N. Wolfe St
Room E8626
Baltimore, MD 21205 map

Academic Affiliations & Courses

Courses and Syllabi

  • Fundamentals of Reproductive Biology (120.620.81)
    Johns Hopkins Bloomberg School of Public Health
  • Genome Integrity (120.605.01)
    Johns Hopkins Bloomberg School of Public Health
  • Principles of Genetics (ME:110.733)
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