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Ravindra Ajith DeSilva, Ph.D.

Photo of Dr. Ravindra Ajith DeSilva, Ph.D.

Instructor of Radiology and Radiological Science

Background

Dr. Ravindra De Silva is an Instructor in the Johns Hopkins Medicine Department of Radiology and Radiological Science and a member of the Johns Hopkins Bayview Medical Center. He specializes in molecular imaging, carbohydrate chemistry, small molecule synthesis and clinical development and manufacturing of imaging and therapeutic agents.

Dr. De Silva received a B.S. chemistry special degree from University of Peradeniya Sri Lanka, and M.Sc. in Inorganic chemistry from National University of Singapore, Singapore. In 2009 he received a Ph.D. in Organic Chemistry from Wayne State University in Detroit, Michigan. 

Before joining Johns Hopkins faculty, he worked an Instructor/ Assistant lab-director at C-TRIC facility University of Colorado Denver, where he was responsible for all clinical development and manufacturing of radiopharmaceuticals for clinically relevant disorders.

As Radiochemistry Director at the Center for Translational Molecular Imaging (CTMI), Johns Hopkins Bayview Medical Center, Dr. De Silva is responsible for clinical development and manufacturing of new imaging and therapeutic agents discovered by Johns Hopkins Scientists and their collaborators. CTMI is the first Academic Research Organization (ARO) created for development of novel radiopharmaceuticals that make possible the vision of individualize medicine.  

 

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Titles

  • Instructor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • B.Sc., University of Peradeniya (Sri Lanka) (1998)
  • Ph.D., Wayne State University (Michigan) (2009)

Additional Training

Radiochemistry and Molecular Imaging, Johns Hopkins University, Baltimore, MD, 2009, Postdoctoral Fellowship

Radiochemistry and Molecular Imaging, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 2009, Postdoctoral Fellowship

Research & Publications

Research Summary

Dr. De Silva’s research program mainly concentrates on utilizing molecular imaging techniques, carbohydrate and organic chemistry, Biochemistry and Mesoporous Silica Nanoparticles (MSNs) to accelerate the discovery and development of effective new radiotracers with more desirable pharmaceutical properties and high target specificity.

Technology Expertise Keywords

Target Specific molecular imaging probes; Glycans; Carbohydrates; Prodrugs; Cancer therapy and imaging; small molecules; Vaccine, Mesoporous Silica Nanoparticles

Selected Publications

Cyclams as Imaging Agents for Chemokine receptor 4 (CXCR4), 41 (7), 552 , Nucl Med Biol, 2014. De Silva, R. A.; Woodard, L. E.; Azard, B. B.; Lisok, A.; Pullambhatla, M.; Lesniak, W. G.; Mease, R. C.; Pomper, M. G.; Nimmagadda, S. Bridged

Development and Characterization of 89Zr-Labeled Panitumumab for ImmunoPET Imaging of the EGF Receptor,12, 1536. Mol Imaging, 2013. De Silva, R. A.; Chang, A. J.; Lapi, S. E.

Copper-64 Radiolabeling and Biological Evaluation of Bifunctional Chelators for Radiopharmaceutical Development, 39(8), 1099. Nucl Med Biol., 2012. De Silva, R. A.; Jain, S.; Lears, K. A.; Chong, H-S.; Kang, C. S. K.; Xiang, S.; Rogers, B. E.

In Vitro and In Vivo Evaluation of a 64Cu-Labeled NOTA-Bn-SCN-Aoc-Bombesin Analog in Gastrin-Releasing Peptide Receptor Expressing Prostate Cancer, 39, 609. Nucl Med Biol., 2012. Craft, J. M.; De Silva, R. A.; Lears, K.; Andrews, R.; Liang, K.; Achilefu, S.; Rogers, B. E.

89Zr-Radiolabeled Trastuzumab Imaging in Orthotopic and Metastatic Breast Tumors, 5, 79. Pharmaceuticals, 2012. De Silva, R. A.; Chang, A. J.; Jain, S.; Lears, K. A.; Rogers, B. E.; Lapi, S.

Activities & Honors

Honors

  • Young Investigator Award, Society of Nuclear Medicine (SNM) Annual Meeting, 2011
  • Herbert K. Livingston Award for Excellence in Teaching, Wayne State University, 2009
  • Willard R. Lenz, Jr. Memorial Scholarship, Wayne State University, 2004

Videos & Media

Lectures and Presentations

  • Molecular imaging CXCR4 with [64Cu]AMD3465
    Presentation , Symposium , CMIIT Young Investigator Award Symposium, Society of Nuclear Medicine Annual Meeting , Texas, USA (06/05/2011)
    Society of Nuclear Medicine
  • An Entirely Carbohydrate Vaccine Construct Based on the Tn-PS A1 Conjugate
    Presentation , NIH & FDA Glycosciences Research Day , Natcher Conference Center, Bethesda, Maryland, USA (05/24/2010)
    NIH & FDA
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