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Avi Z Rosenberg, M.D., Ph.D.
Assistant Professor of Pathology
Languages: English, Yiddish
Expertise: Pathology , Pediatric Pathology, Placental Pathology, Renal Pathology
Research Interests: Mechanisms of renal parenchymal fibrosis; ApoL1-related kidney diseases; Diabetic Kidney diseases
The Johns Hopkins Hospital (Main Entrance)
1800 Orleans St. Baltimore, MD 21287
Dr. Rosenberg is a physician-scientist and practicing renal pathologist at the Johns Hopkins University School of Medicine. During residency he worked in the laboratory of Dr. Michael Emmert-Buck to collaboratively develop a new iteration of a microdissection technique called expression microdissection (PLoS One. 2016). The goal of this tool was to improve rapidity and throughput of cell-specific and subcellular microdissection for downstream bioanalyte analysis. Also at the NIH Dr. Rosenberg developed an interest in primary kidney diseases and explored these areas in the laboratories of Dr. Jeffrey Kopp and in collaboration with Dr. Moshe Levi. It is here that he gained expertise in in vitro and in vivo models of kidney diseases of focal and segmental glomerulosclerosis, diabetes, obesity-related glomerulopathy and microangiopathic injuries. Dr. Rosenberg enjoys tackling complex kidney centered problems using a diverse array of molecular, cell biological and analytical tools. His research group includes a postdoctoral fellow and a research specialist. He also has taught medical students and residents across various levels and takes these opportunities to ignite future physician scientist's excitement to pursue a deeper interest in mechanisms of disease.
Avi completed his M.D., Ph.D. at Stony Brook University which included PhD research in the Laboratory of Senthil Muthuswamy at Cold Spring Harbor Laboratory studying the role of polarity regulators in breast development and neoplasia.
- Assistant Professor of Pathology
Departments / Divisions
- Pathology - Kidney-Urologic Pathology
- MD; Medicine, SUNY at Stony Brook School of Medicine (2011)
- National Institutes of Health / Anatomic Pathology (2014)
- Johns Hopkins University School of Medicine (2015)
- Children's National Medical Center / Pathology (2016)
Research & Publications
My research laboratory studies mechanisms of chronic kidney disease with focuses on mechanisms of fibrosis, structural kidney abnormalities in development, diabetic kidney disease and focal and segmental glomerulosclerosis.
- Comprehensive understanding of kidney fibrosis evolution in nephrotic syndromes and chronic kidney disease in general. To this end as a member of the Nephrotic Syndrome Network (NEPTUNE) we are deconvoluting transcriptomic signatures of fibrosis in an incident cohort of nephrotic syndromes. Also to model fibrosis and to image fibrosis, collaborative efforts with Drs. Moshe Levi and Jeffrey Kopp are underway to use advanced non-destructive imaging techniques and sensitive proteomic techniques in model systems of renal fibrosis in the setting of diabetes and obesity.
- We are using iPSC-derived renal organoids to model genetic forms of kidney disease as well as forms of kidney injury that are driven by environmental aberration. A principle area of interest using these models is to explore the effects of ApoL1 risk alleles and their associated toxicities on various cell compartments.
- Using expression microdissection (xMD) we are performing cellular microdissection followed by high-throughput next generation techniques for DNA, mRNA, small RNAs and protein to build cell-level datasets for comparison with diseased bioanalyte profiles of matched cellular subsets.
Activities & Honors
- Betta Kappa Society
- BA/BS Magna cum laude Brooklyn College Honors Academy – Scholars Program, 1997 - 2001
- Medical Scientist Training Program, Stony Brook University, 2001 - 2011
- Co-chief Resident, Anatomic Pathology Training Program, Laboratory of Pathology, NIH, 2013 - 2014
- Outstanding Poster Award, Renal Pathology Society, USCAP, 2015
- Gary S. Hill Award, 2017
- United States and Canadian Academy of Pathology
- Renal Pathology Society
- Society of Pediatric Pathology
- Association for Molecular Pathology
- American Society of Nephrology
- American Society of Mass Spectroscopy
- Finance Committee, Renal Pathology Society
- Perinatal Pathology Committee, Society of Pediatric Pathology