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Manisha Aggarwal, M.S.E., Ph.D.

Photo of Dr. Manisha Aggarwal, M.S.E., Ph.D.

Assistant Professor of Radiology and Radiological Science

Research Interests: Diffusion MRI; high-field MRI acquisition techniques; pre-clinical MRI; susceptibility imaging; neuroimaging; brain atlasing; neurodegenerative diseases; oscillating gradient diffusion MRI more


Manisha Aggarwal, Ph.D., is an Assistant Professor in the Johns Hopkins Medicine Division of MR Research in the Department of Radiology and Radiological Science.

Dr. Aggarwal is an investigator whose research focuses on high-field magnetic resonance imaging (MRI) techniques, advanced diffusion micro-imaging and acquisition methods, pre-clinical MRI, and the applications of these techniques for brain imaging. 

Dr. Aggarwal earned Ph.D. and M.S.E. degrees in biomedical engineering from the Johns Hopkins University School of Medicine. She holds a Bachelor of Technology (Honors) degree in instrumentation engineering and a minor in electronics and electrical communication engineering from the Indian Institute of Technology, Kharagpur, in India. She completed her post-doctoral work in Radiology at Johns Hopkins University. 

Dr. Aggarwal is a Siebel Scholar and a Junior Fellow of the International Society for Magnetic Resonance in Medicine. more


  • Assistant Professor of Radiology and Radiological Science

Departments / Divisions



  • B.Tech., Indian Institute of Technology (Kharagpur) (India) (2004)
  • M.S.E., Johns Hopkins University (Maryland) (2006)
  • Ph.D., Johns Hopkins University School of Medicine (Maryland) (2012)

Research & Publications

Research Summary

Dr. Aggarwal's research focuses on advanced magnetic resonance imaging (MRI) techniques and their applications to mapping of brain tissue microstructure in the human brain and in pre-clinical models. Her primary research areas include:

1. High-field diffusion micro-imaging techniques and pulse sequences

2. Characterization of brain tissue microstructure using diffusion and susceptibility MR methods

3. Oscillating gradient diffusion MRI and its applications to animal models of neurological disorders

4. High-resolution neuroimaging, and development of computational brain atlases


Selected Publications

View all on Pubmed

Aggarwal M., Kageyama Y., Li X., van Zijl P. B0-orientation dependent magnetic susceptibility-induced white matter contrast in the human brainstem at 11.7T. Magn Reson Med. 2016 Jun;75(6):2455-66.

Aggarwal M., Nauen DW., Troncoso JC., Mori S. Probing region-specific microstructure of human cortical areas using high angular and spatial resolution diffusion MRI. Neuroimage. 2015 Jan 15;105:198-207.

Aggarwal M., Burnsed J., Martin LJ., Northington FJ., Zhang J. Imaging neurodegeneration in the mouse hippocampus after neonatal hypoxia-ischemia using oscillating gradient diffusion MRI. Magn Reson Med. 2014 Sep;72(3):829-40.

Aggarwal M., Zhang J., Pletnikova O., Crain B., Troncoso J., Mori S. Feasibility of creating a high-resolution 3D diffusion tensor imaging based atlas of the human brainstem: a case study at 11.7 T. Neuroimage. 2013 Jul 1;74:117-27.

Aggarwal M., Jones MV., Calabresi PA., Mori S., Zhang J. Probing mouse brain microstructure using oscillating gradient diffusion MRI. Magn Reson Med. 2012 Jan 67(1):98-109.

Contact for Research Inquiries

720 Rutland Avenue
217 Traylor Building
Baltimore, MD 21205 map

Activities & Honors


  • Junior Fellow, International Society for Magnetic Resonance in Medicine, 2013
  • Siebel Scholar, 2012
  • Phi Beta Kappa, 2012
  • Finalist, ISMRM I. I. Rabi Young Investigator Award, 2010


  • International Society for Magnetic Resonance in Medicine
  • Society for Neuroscience

Videos & Media

Lectures and Presentations

  • Altered hippocampal microstructure in the epileptogenic rat brain revealed with diffusion MRI using oscillating field gradients
    Oral, ISMRM Annual Meeting (05/13/2016)
  • Thalamic nuclei-specific deposits of iron and calcium in the epileptogenic rat brain revealed by quantitative susceptibility mapping
    Oral, ISMRM Annual Meeting (05/12/2016)
  • Pre-clinical and postmortem diffusion imaging
    Organization for Human Brain Mapping (OHBM) Annual Meeting (06/14/2015)
  • B0-orientation dependent susceptibility-induced white matter contrast in the human brainstem
    Oral, ISMRM Annual Meeting (06/04/2015)
  • Imaging the microstructure of the developing cerebral cortex in the mouse embryo with diffusion MR microscopy
    Oral, Joint Annual Meeting ISMRM-ESMRMB (05/12/2014)
  • Probing cytoarchitectural heterogeneity in the human hippocampus with oscillating gradient diffusion tensor imaging
    Oral, ISMRM Annual Meeting (04/26/2013)
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