- Assistant Professor of Oncology
the role of the extracellular matrix in cancer metastasis; hypoxia and the tumor microenvironment; transcriptional regulation by hypoxia-inducible factors ...read more
Gilkes DM, Chen L, Chen J. MDMX regulation of p53 response to ribosomal stress. The EMBO journal. 2006;25(23):5614-25.
Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL. Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts. Journal of Biological Chemistry. 2013;288(15):10819-29.
Gilkes DM, Bajpai S, Wong CC, Chaturvedi P, Hubbi ME, Wirtz D, Semenza GL. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. Molecular Cancer Research. 2013;11(5):456-66.
Gilkes DM, Chaturvedi P, Bajpai S, Wong CC, Wei H, Pitcairn S, Hubbi ME, Wirtz D, Semenza GL. Collagen prolyl hydroxylases are essential for breast cancer metastasis. Cancer research. 2013;73(11):3285-96.
Gilkes DM, Semenza GL, Wirtz D. Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nature Reviews Cancer. 2014;14(6):430-9.