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Ann Sunah Choe, Ph.D.

Photo of Dr. Ann Sunah Choe, Ph.D.

Instructor of Radiology and Radiological Science

Research Interests: Magnetic resonance imaging; MRI, diffusion tensor imaging; DTI; functional MRI; fMRI; brain plasticity; rehabilitation; central nervous system; CNS; spinal cord injury; SCI ...read more

Contact for Research Inquiries

707 North Broadway,
Room G-25
Baltimore, MD 21205 map

Background

Dr. Ann S. Choe is a Research Instructor in the Department of Radiology and Radiological Sciences at the Johns Hopkins University School of Medicine. 

Dr. Choe’s research interests include:

• Theoretical and clinical study of central nervous system (CNS)

• Roles that neuroimaging plays in the diagnosis and monitoring of diseases that affect motor functions, such as spinal cord injury, stroke, and multiple sclerosis

• Development of more accurate and precise imaging method for better diagnosis of diseases

• Structural and functional connectivity information provided by MR and its implications

• Use of MRI information to aid design of individual rehabilitation program

She has expertise and experience in magnetic resonance (MR) physics, imaging science, mathematics, as well as spinal cord and brain imaging of spinal cord inured (SCI) patients. The overall goal of her ongoing study is to establish resting state functional magnetic resonance imaging (rs-fMRI) of the brain as a clinical tool to evaluate the extent and the pattern of cortical plasticity in SCI patients, in response to therapeutic intervention.

Dr. Choe has received her Ph.D. from Vanderbilt University in Biomedical Engineering. Her research experience as a graduate student in the field of diffusion tensor imaging (DTI) served as a basis for the rest of her career in the field of imaging science. During this time, Dr. Choe has acquired expertise in many aspects of MRI, including imaging physics, image processing, and data analysis, and completed didactic coursework in the areas of biomedical imaging, signal and image processing, instrumentation, as well as physiology. 

Dr. Choe is a recipient of the Gates Millennium Scholars Award from the Bill and Melinda Gates Foundation and the Neilsen Postdoctoral Fellowship Research Grant from the Craig H. Neilsen Foundation.

 

...read more

Titles

  • Instructor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • Ph.D., Vanderbilt University (Tennessee) (2010)

Research & Publications

Research Summary

Dr. Choe has expertise and experience in magnetic resonance (MR) physics, imaging science, mathematics, as well as spinal cord and brain imaging of spinal cord inured (SCI) patients. The overall goal of her ongoing study is to establish resting state functional magnetic resonance imaging (rs-fMRI) of the brain as a clinical tool to evaluate the extent and the pattern of cortical plasticity in SCI patients, in response to therapeutic intervention.

Technology Expertise Keywords

C; C++; Matlab; Insight Tookit (ITK); Varian 4.7T; 9.4T; Bruker 11.7T; Philips 3T; DTIStudio; FSL; SPM; AFNI

Selected Publications

View all on Pubmed

Choe AS, Belegu V, Yoshida S, Joel SE, Sadowsky CL, Smith SA, van Zijl PC, Pekar JJ, McDonald JW, Extensive neurological recovery from a complete spinal cord injury: a case report and hypothesis on the role of cortical plasticity. 2013 Jun; 7:290. PMCID: PMC3691521

Gao Y, Choe AS, Stepniewska I, Li X, Anderson AW, Validation of DTI-tractography-based measures of primary motor area connectivity in squirrel monkey brain PLoS One. 2013 Oct 1;8(10):e75065 PMCID: PMC3788067. Prepared samples and constructed data acquisition pipeline.

Nebel MB, Eloyan A, Nettles CA, Sweeney KL, Ament K, Ward RE, Choe AS, Barber AD, Pekar JJ, Mostofsky S. Intrinsic Visual-Motor Synchrony Correlates With Social Deficits in Autism. Biological Psychiatry. Advance online publication. doi: doi:10.1016/j.biopsych.2015.08.029 Aided in construction of initial experimental concept and data analysis.

Choe AS, Joel SE, Jones CK, Muschelli J, Belegu V, McDonald JW, Caffo BS, van Zijl PC, Pekar JJ. Reproducibility and Temporal Structure in Weekly Resting-State fMRI over a Period of 3.5 Years. PLoS ONE. 2015 Oct 30;10(10):e0140134.

Sair HI, Yahyavi-Firouz-Abadi N, Calhoun VD, Airan RD, Agarwal S, Intrapiromkul J, Choe AS, Gujar SK, Caffo B, Lindquist MA, Pillai JJ. Presurgical brain mapping of the language network in patients with brain tumors using resting-state fMRI: Comparison with task fMRI Hum Brain Mapping 2015. Provided experimental feedback.

Academic Affiliations & Courses

Courses and Syllabi

  • Introduction to Engineering, Teaching Assistant
    Vanderbilt University
    2004 - 2005
  • Introduction to Biological Sciences, Teaching Fellow
    Notre Dame of Maryland University
    2013
  • “Planning and Conducting Clinical Research: An Introduction”, 2nd ICSCI Clinical Short Course, Lecturer
    Kennedy Krieger Institute, International Center for Spinal Cord Injury
    2015
  • “Changes in DTI parameters below the injury epicenter are related to neurological measures in chronic spinal cord injury”, Lecturer
    Johns Hopkins University School of Medicine, Radiology and Radiological Sciences
    2013 - 2016

Activities & Honors

Honors

  • Gates Millennium Scholar, Bill and Melinda Gates Foundation; Full undergraduate and graduate tuition award, 2000 - 2010
  • Student Stipend Award, International Society for Magnetic Resonance in Medicine (ISMRM), 2007 - 2009
  • Best Poster Award, Korean Society for Magnetic Resonance in Medicine (KSMRM), 2013
  • 2013 Teaching Fellow, Teaching Fellow Program, Johns Hopkins University Professional Development Office (PDO), 2013

Memberships

  • Korean Students and Scholars Association, 2008 - 2010

    Dr. Choe was a member from 2008-2010 and President from 2009-2010.

  • Johns Hopkins Interdisciplinary Biomedical Research Group (JHIBRG), 2012 - 2013
  • Baltimore Life Scientists Association (BLSA), 2012 - 2014

    Dr. Choe was the Financial Officer from 2012-2013, and member from 2012-2014.

  • Society for Neuroscience (SfN), 2013 - 2015
  • Korean Women in Science and Engineering, 2013 - 2014

    Dr. Choe was a member and Treasurer from 2013-2014.

  • International Society for Magnetic Resonance in Medicine (ISMRM), 2010 - 2015

Videos & Media

Lectures and Presentations

  • Trends, seasonality, and persistence of resting-state fMRI over 185 weeks.
    Presentation , 23rd Scientific Meeting and Exhibition , Toronto, Canada (05/30/2015)
    ISMRM 2015
  • Regional measures of water diffusion associated with impairment in chronic SCI.
    presentation , 24th Scientific Meeting and Exhibition , Suntec City, Singapore (05/07/2016)
    ISMRM 2016
  • Comparison of BOLD and CBV-weighted resting state connectivity to an anatomical ‘gold standard’ in the motor network of the squirrel monkey brain.
    presentation , 23rd Annual Meeting, ISMRM , Toronto, Canada (05/30/2015)
    ISMRM
  • Evaluating the Reproducibility of Dynamic Connectivity in fMRI.
    presentation , 2015 IEEE International Symposium on Biomedical Imaging , Brooklyn, NY (05/30/2015)
    IEEE
  • Reproducibility and temporal structure in weekly resting-state fMRI over a period of 3.5 years.
    presentation , 3rd Scientific Whistler Workshop 2016 , Whistler, CA (03/06/2016)

Recent News Articles and Media Coverage

Interviewed for a commentary on my PlosOne manuscript (#7). Reas, Emilie. “How reliable is resting state fMRI?” PLOS Neuro. 14 Jan 2016. Web. 3 Feb 2016. 

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