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Amde Selassie Shifera, M.D., M.S., Ph.D.

Photo of Dr. Amde Selassie Shifera, M.D., M.S., Ph.D.
  • Assistant Professor of Ophthalmology

Languages: English, Amharic


Ocular Immunology, Ocular Inflammation Disease, Ophthalmology, Uveitis

Research Interests

sarcoidosis; Vogt-Koyanagi-Harada syndrome; development of nanotechnology-based treatment modalities for uveitis

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The Johns Hopkins Hospital

Appointment Phone: 410-955-2966
600 N. Wolfe Street
Wilmer Eye Institute
Baltimore, MD 21287 map
Fax: 410-955-2924

Johns Hopkins Wilmer Eye Institute - White Marsh

Appointment Phone: 443-442-2020
4924 Campbell Boulevard
Suite 100
Nottingham, MD 21236 map
Phone: 443-442-2020


Amde Selassie Shifera, M.D., Ph.D., is an assistant professor of ophthalmology at the Wilmer Eye Institute. In addition to comprehensive ophthalmology, he specializes in ocular immunology, including uveitis, panuveitis, scleritis and ocular inflammatory and infectious diseases. His research focuses on investigating the causes of uveitis and in developing new and better means of treatment for uveitis. 

Dr. Shifera received his M.D. from Addis Ababa University in Ethiopia. After ten years of clinical practice in Ethiopia as a general practitioner, he moved to the United States and completed a master’s degree in clinical chemistry at West Chester University and then a Ph.D in microbiology and immunology at the Albert Einstein College of Medicine. Following postdoctoral research fellowships at both Albert Einstein and the University of California, San Francisco, he completed an internship in surgery at the University of Colorado and then his residency in ophthalmology at the University of Florida. Prior to joining the Wilmer faculty in 2015, Dr. Shifera completed a clinical fellowship in uveitis at the Casey Eye Institute at Oregon Health & Science University. more


  • Assistant Professor of Ophthalmology

Departments / Divisions



  • MD, Faculty of Medicine Addis Ababa University (1989)


  • UF Health Shands Hospital / Ophthalmology (2014)


  • Oregon Health and Sciences University Hospital / Uveitis & External Disease (2015)

Board Certifications

  • Pending/Scheduled / Ophthalmology

Research & Publications

Research Summary

Research bacterial and fungal DNA in conjunctival sarcoid granulomas (2015 to present)

Research cell signaling pathways cytokines and monocytes in the homeostasis of intraocular pressure and in the pathogenesis of glaucoma (2009-2010) 

Investigate the effects of vitamin D on cellular signaling pathways and the role of vitamin D deficiency in the pathogenesis of systemic lupus erythematosus (2007-2009)

Examine the effects of mutations in IKKγ (NEMO) protein associated with hypohidrotic ectodermal dysplasia-immune deficiency (2001-2007)

Clinical Trials

Uveitic Macular Edema Trial (POINT) clinical trial

Selected Publications

Choi CS, Zhang L, Abràmoff MD, Sonka M, Shifera AS, Kay CN. Evaluating efficacy of aflibercept in refractory exudative age-related macular degeneration with OCT segmentation volumetric analysis. Ophthalmic Surg Lasers Imaging Retina 2016; 47:245-251

Alvarado JA, Chau P, Wu J, Juster R, Shifera AS, Geske M. Profiling of cytokines secreted by conventional aqueous outflow pathway endothelial cells activated iIn vitro and ex vivo with laser irradiation. Invest Ophthalmol Vis Sci 2015; 56:7100-7108

Shifera AS, Kay CN. Early-onset X-linked retinitis pigmentosa in a heterozygous female harboring an intronic donor splice site mutation in the retinitis pigmentosa GTPase regulator gene. Ophthalmic Genet 2015; 36:251-256

Shifera AS, Suhler EB. An overview of biological therapy for immune-mediated uveitis. Ophthalmol Int 2014; 9:119-122

Shifera AS, Leoncavallo A, Sherwood M. Probable association of an attack of bilateral acute angle-closure glaucoma with duloxetine. Ann Pharmacother 2014; 48:936-939

Alvarado JA, Iguchi R, Martinez J, Trivedi S, Shifera AS. Similar effects of selective laser trabeculoplasty and prostaglandin analogs on the permeability of cultured Schlemm canal cells. Am J Ophthalmol 2010;150:254-264

Shifera AS, Kopplin L, Lin P, Suhler EB. Drug-induced uveitis. Int Ophthalmol Clin. 2015; 55:47-65

Kopplin LJ, Shifera AS, Suhler EB, Lin P. Biological response modifiers in the treatment of noninfectious uveitis. Int Ophthalmol Clin. 2015; 55:19-36

Alvarado JA, Shifera AS. Progress toward understanding the functioning of the trabecular meshwork based on lessons from studies on laser trabeculoplasty (editorial). Br J Ophthalmol 2010; 94:1417-1418

Activities & Honors


  • Mallinckrodt Research Fellowship Award, Mallinckrodt Foundation, 2015
  • Full Graduate Assistantship, West Chester University of Pennsylvania, 1999 - 2001
  • Addis Ababa University Medal, Addis Ababa University, 1988 - 1988


  • International Society for Eye Research, 2016
  • American Academy for Ophthalmology, 2011
  • Association for Research in Vision and Ophthalmology, 2010

Professional Activities

  • Volunteer, Ethiopian-Netherlands AIDS Research Project, Ethiopia, 1995

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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