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Nicole Schmitt, M.D.

Nicole Cherie Schmitt, M.D.

Photo of Dr. Nicole Schmitt, M.D.

Assistant Professor of Otolaryngology - Head and Neck Surgery


Languages: English, French

Expertise: Benign Tumors of the Head and Neck, Carcinoma of the Tongue, Head and Neck Cancers, Head and Neck Conditions, Head and Neck Surgery, Head and Neck Tumors, Laryngeal Cancer, Minor Salivary Gland Cancers, Oral Cancers, Oral Cavity Cancers, Otolaryngology (ENT), Parotid Cancer, Parotid Gland Tumors, Salivary Gland Tumors, Sentinel Lymph Node Biopsy, Thyroid Cancer, Thyroid Masses, Thyroid Tumors, Tongue Cancer, Tonsil Cancer more

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Johns Hopkins Otolaryngology - Head and Neck Surgery
Appointment Phone: 301-896-3330

6420 Rockledge Drive
Suite 4920
Bethesda, MD 20817 map
Phone: 301-896-3330


Dr. Nicole Schmitt is a fellowship-trained head and neck cancer surgeon. Her clinical interests include surgical treatment and surveillance of patients with benign and malignant tumors of the head and neck, robotic surgery, benign and malignant thyroid and parathyroid disease, and skin cancers of the head and neck. Dr. Schmitt’s research interests include the use of platinum-based chemotherapy drugs and immunotherapy for the treatment of head and neck cancer. She holds a joint appointment at the National Institutes of Health.

Dr. Schmitt earned her medical degree from the Washington University School of Medicine in St. Louis, Missouri, and completed her residency training in otolaryngology at the University of Washinton in Seattle, Washington. Dr. Schmitt also completed two fellowships: a research fellowship at the University of Washington in Seattle and a head and neck surgical oncology fellowship at the University of Pittsburgh. more


  • Assistant Professor of Otolaryngology - Head and Neck Surgery

Departments / Divisions



  • MD, Washington University School of Medicine in St Louis (2006)


  • University of Washington Medical Center / Otolaryngology Head and Neck Surgery (2013)


  • University of Pittsburgh Medical Center / Head and Neck Surgery (2015)

Board Certifications

  • American Board of Otolaryngology / Otolaryngology (2014)

Research & Publications

Research Summary

Dr. Schmitt’s research interests include mechanisms and toxicity profiles of platinum-based chemotherapy drugs. Current studies are focused on improving our understanding of the mechanisms by which these drugs kill head and neck cancer cells, as well as ways to combine them with other chemotherapeutic, targeted or immune therapies to improve their efficacy and decrease associated toxicities. Dr. Schmitt has also published on hearing loss associated with platinum-based chemotherapy agents.

Selected Publications

View all on Pubmed

Schmitt NC, Sharma A, Gilbert MR, Kim S. Early T stage salivary duct carcinoma: Outcomes and implications for patient counseling. Otolaryngol Head Neck Surg, in press.

Schmitt NC, Ferris RL. STAT1 activation is enhanced by cisplatin and variably affected by EGFR inhibition in HNSCC cells. Mol Cancer Ther. 2015 Jul 3. pii: molcanther.0305.2015.

Mitchell RM, Mendez E, Schmitt NC, Bhrany AD, Futran ND. Antibiotic prophylaxis in patients receiving free flap reconstruction. JAMA Otolaryngol 2015; doi:10.1001/jamaoto.2015.0513.

Schmitt NC, Duvvuri U. Transoral robotic surgery for oropharyngeal squamous cell carcinoma. Curr Opin Otolaryngol Head Neck Surg 2015; 23: 127-131.

Trivedi S, Concha-Benavente F, Srivastava RM, Jie HB, Gibson SP, Schmitt NC, Ferris RL. Immune biomarkers of anti-EGFR monoclonal antibody therapy in squamous cell carcinomas of the head and neck. Ann Oncol 2014; 26:40-47.

Hodnett BL, Schmitt NC, Clayburgh DR, Burkowsky A, Balzer J, Thirumala PD, Duvvuri U. Superior Laryngeal Nerve Monitoring using Laryngeal Surface Electrodes and Intraoperative Neurophysiological Monitoring. Clin Anat 2014; 28:460-466.

Schmitt NC, Rubel EW. Osteopontin does not mitigate cisplatin ototoxicity or nephrotoxicity in adult mice. Otolaryngol Head Neck Surg 2013; 149:614-620.

Activities & Honors


  • Young Investigator Award, American Head and Neck Society and American Academy of Otolaryngology – Head and Neck Surgery, 2013


  • American Head and Neck Society, 2015
  • American Thyroid Association, 2015
  • American Society of Clinical Oncology, 2014
  • American Academy of Otolaryngology Head and Neck Surgery, 2006
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