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Jessie R. Nedrow, Ph.D.

Photo of Dr. Jessie R. Nedrow, Ph.D.

Assistant Professor of Radiology and Radiological Science

Background

Dr. Jessie Nedrow is an Assistant Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science. 

Dr. Nedrow received her bachelor degree from Idaho State University and her Ph.D in Chemistry from Washington State University.

Dr. Nedrow's research interests include the development of radiopharmaceuticals for targeted alpha therapy and imaging applications; the development and application of PSMA-targeted radiotheranostics; and synthesis and evaluation of peptides modified for labeling with copper-64, gallium-68, and lutetium-177 for use as molecular imaging and therapeutic agents. 

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Titles

  • Assistant Professor of Radiology and Radiological Science

Departments / Divisions

Education

Degrees

  • B.A., Idaho State University (Idaho) (2007)
  • Ph.D., Washington State University (Washington) (2012)

Research & Publications

Research Summary

Dr. Nedrow's research interests include the development of radiopharmaceuticals for targeted alpha therapy and  imaging applications; synthesis and evaluation of peptides modified for labeling with copper-64, gallium-68, and lutetium-177 for use as molecular imaging and therapeutic agents; the development and application of PSMA-targeted radiotheranostics; and the development and evaluation of prostate specific membrane antigen (PSMA) targeted phosphoramidate and phosphate inhibitors, modified to deliver an imaging payload to PSMA positive cells in vitro and in vivo.

Selected Publications

Pharmacokinetics, micro-scale distribution and dosimetry of alpha-emitter labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model. Jessie R Nedrow*, Anders Josefsson*, Sunju Park, Tom Bäck, Robert F. Hobbs, Cory Brayton, Frank Bruchertseifer, Alfred Morgenstern, and George Sgouros. European Journal of Nuclear Medicine and Molecular Imaging, accepted.

Human HER2 overexpressing mouse breast cancer cell lines derived from MMTV.f.HuHer2 mice: Characterization and use in a model of metastatic breast cancer. Sunju Park, Jessie R. Nedrow, Anders Josefsson, and George Sgouros. Oncotarget, accepted.

Imaging of programmed death ligand-1 (PD-L1): impact of protein concentration on distribution of anti-PD-L1 SPECT agent in an immunocompetent melanoma murine model. Jessie R. Nedrow, Anders Josefsson, Sunju Park, Sagar Ranka, Sanchita Roy, and George Sgouros. Journal of Nuclear Medicine, accepted.

Emerging Radiometals for PET Imaging. Jessie R. Nedrow and Carolyn J. Anderson. Encyclopedia of Inorganic and Bioinorganic Chemistry, Online @ 2011-2016 John Wiley & Sons, Ltd.

Imaging, biodistribution, and dosimetry of radionuclide-labeled PD-L1 antibody in an immunocompetent mouse model of breast cancer. Anders Josefsson*, Jessie R. Nedrow*, Sunju Park, Sangeeta Ray Banerjee, Andrew Rittenbach, Fabien Jammes, Benjamin Tsui, George Sgouros. Cancer Research, 2016, 76(2): 472-9.

Academic Affiliations & Courses

Courses and Syllabi

  • Organic Chemistry I

    Activities & Honors

    Honors

    • Patricia Bell Scholarship, 2002
    • Idaho Promise Scholarship, 2002 - 2004
    • ASUISU Scholarship, 2003 - 2004
    • Gardner Stacey Research Endowment, 2010
    • International Symposium on Radiopharmaceutical Sciences Travel Bursary, 2013
    • DOE Postdoctoral Fellowship: Integrated Nuclear Medicine, 2012 - 2015
    • Research and Training Projects of Excellence: Ciceric Rad BriteStar Award, 2017 - 2018
    • 10th International Symposium on Targeted Alpha Therapy Travel Award, 2017

    Memberships

    • American Chemical Society, 2005
    • Society of Nuclear Medicine and Molecular Imaging, 2014
    • American Association of Cancer Research, 2016

    Professional Activities

    • Member, Idaho State University: Chemistry Club, 2005
    • Washington State University: Graduate Chemistry Students (WSUGCS), Member and Treasurer, 2007
    • 4th Annual Maryland STEM Career Fair, Volunteer, 2016

    Videos & Media

    Lectures and Presentations

    • Reducing renal uptake of free 213Bi associated with the decay of 225Ac-labeled radiopharmaceuticals.
      poster, 10th International Symposium on Targeted Alpha Therapy, Kanazawa, Japan (05/01/2017)
    • Pharmacokinetic profiling and therapeutic efficacy of alpha-emitter labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model
      oral, 10th International Symposium on Targeted Alpha Therapy, Kanazawa, Japan (05/01/2017)
    • Pharmacokinetic profiling and therapeutic efficacy of alpha-emitter labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model.
      poster, Johns Hopkins 10th Annual Breast Cancer Retreat (04/01/2017)
      Johns Hopkins Medicine
    • Radionuclide Therapy and Dosimetry (RTD) Lab: Pre-Clinical Applications.
      Oral, Division of Nuclear Medicine and Molecular Imaging, Baltimore, MD (02/01/2017)
    • Combining a-particle radiopharmaceutical therapy using Actinium-225 and immunotherapy with anti-PD-L1 antibodies in a murine immunocompetent metastatic breast cancer model.
      poster, Johns Hopkins 7th Annual Breast Cancer Retreat, Baltimore, MD (05/01/2016)
      Johns Hopkins Medicine
    • The impact of protein concentration on the distribution of 111In-antibody conjugate for imaging of Programmed death-ligand 1 (PD-L1).
      poster, AACR Annual Meeting, New Orleans, LA (03/01/2016)
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