Dr. Casadevall is a globally known expert in humoral immunity, molecular biology, virulence and cryptococcosis. The goal of his research is to protect people from harm caused by new pathogens and resistant organisms, and by compromised immune systems resulting from HIV, cancer therapy treatments and other causes.
Dr. Casadevall’s laboratory studies two fundamental questions: First, how do microbes cause disease? Second, how do hosts, such as humans, protect themselves against microbes? To address these large questions, the laboratory has a multidisciplinary research program spanning several areas of basic immunology and microbiology.
A major focus of the laboratory is the fungus Cryptococcus neoformans, a ubiquitous environmental microbe that is a frequent cause of disease in individuals with impaired immunity. The fungus causes lung infection, including a particularly dangerous fungal meningitis observed primarily in immune-compromised patients such as those with AIDS. Many of the laboratory’s projects seek to understand how hosts defend against C. neoformans and how the Cryptococcus organism’s virulence contributes to disease. For example, melanin production in C. neoformans, is associated with virulence. Melanin is a pigment with an undefined chemical structure and tremendous physical stability. This pigment accumulates in the cell wall of C. neoformans and allows growth and budding to occur. But melanin research also has wide reach: An antibody to fungal melanin made in the Casadevall laboratory is currently in evaluation for the treatment of melanoma, a type of skin cancer.
In recent years the laboratory has also worked with other microorganisms, including Bacillus anthracis, a bacterium that causes anthrax and is a major agent of biological warfare because it produces spores that can be easily dispersed. The laboratory is interested in devising antibody-based countermeasures to protect against anthrax.
Casadevall A, Pirofski LA. "What is a host? Incorporating themicrobiota into the damage-response framework." Infect Immun. 2015 Jan;83(1):2-7. doi: 10.1128/IAI.02627-14. Epub 2014 Nov 10.
Fang FC, Casadevall A. "Competitive science: Is competition ruining science." Infect Immun. 2015 Jan 20. pii: IAI.02939-14.
Achkar JM, Chan J, Casadevall A. "B cells and antiboides in the defense against Mycobacterium tuberculosis infection." Immunol Rev. Mar;264(1):167-81. doi: 10.1111/imr.12276.
Coelho C, Oliveira Souza AC, Derengowski L, de Leon-Rodriguez C, Wang B, Leon-RiveraR, Bocca, AL, Gonçalves T, Casadevall A. "Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans." J. Immunol. Mar 1;194(5):2345-57. doi: 10.4049/jimmunol.1402350. Epub 2015 Feb 2.
Duprex WP, Casadevall A. "Falling down the rabbit hole: aTRIP toward lexiconic precision in the 'gain-of-function' debate." Mbio. pii: e02421-14. doi: 10.1128/mBio.02421-14.
Imperiale MJ, Casadevall A. "Vagueness and costs of the pause on gain-of-function (GOF) experiments on pathogens with pandemic potential, including influenza virus." Mbio. pii: e02292-14. doi: 10.1128/mBio.02292-14.