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Seulki Lee, Ph.D.

Photo of Dr. Seulki Lee, Ph.D.
  • Associate Professor of Radiology and Radiological Science

Research Interests

Role of TRAIL signaling in fibrosis and cancer


Dr. Seulki Lee is Associate Professor of Radiology and Radiological Science with secondary appointments in Ophthalmology, Oncology and Materials Science and Engineering and a member of the Johns Hopkins Kimmel Cancer Center. His research group focuses on exploring GLP-1 signaling in neurodegenerative disorders and TRAIL signaling in fibrosis diseases and cancer for the development of novel therapies. Dr. Lee is an expert in drug and protein drug delivery, nanotechnology and molecular imaging leading to more than 140 articles in peer-reviewed journals and 20 patents for drug/protein deliver and diagnostic imaging methods. 

Prior to joining Johns Hopkins, Dr. Lee was the inaugural section leader of the Theranostic Nanomedicine Section at the National Institute of Biomedical Imaging and Bioengineering (NIBIB/NIH). Currently, his team is evolving its research endeavors from drug delivery to explore TRAIL biology in fibrosis and cancer towards clinical translation. 

Dr. Lee has received multiple awards, including the NRC Associateship from the National Academy of Sciences, the NIH Pathway to Independence Award (K99/R00), Career Development Award and Investigator-Initiated Research Award from the Department of Defense, Thome Memorial Foundation Award and the Maryland Innovation Initiative Award. Dr. Lee was selected as a 2017 Highly Cited Researchers. more


  • Associate Professor of Radiology and Radiological Science
  • Assistant Professor of Ophthalmology

Departments / Divisions



  • Ph.D., Gwangju Institute of Science and Technology (South Korea) (2006)
  • B.S., Sungkyunkwan University (South Korea) (2002)

Additional Training

Department of Radiology, Stanford School of Medicine, Stanford, CA, 2009, Postdoctoral Fellow; Biomedical Research Center, KIST, Seoul, South Korea, 2008, Research Fellow

Research & Publications

Selected Publications

Kim TH, Swierczewska M, Oh Y, Kim A, Jo DG, Park JH, Byun Y, Sadegh-Nasseri S, Pomper MG, Lee KC, Lee S, Mix to validate: a facile, reversible PEGylation for fast screening of potential therapeutic proteins in vivo. Angewandte Chemie International Edition. 2013; 52(27): 6880-6884. [Cover feature] PMID: 23740787

Oh Y, Ogyi Park, Swierczewska M, Hamilton JO, Park JS, Kim TH, Lim SM, Eom H, Jo DG, Lee CE, Kechrid R, Mastorakos P, Zhang C, Hahn SK, Jeon OC, Byun R, Ki K, Hanes J, Lee KC, Pomper MG, Gao B, Lee S, Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells. Hepatology, 2016; 64(1): 209-223. PMID: 26710118

Park JS, Oh Y, Park O, Foss CA, Lim CA, Lim SM, Jo DG, Na DH, Pomper MG, Lee KC, Lee S, PEGylated TRAIL ameliorates experimental inflammatory arthritis by regulation of Th17 cells and regulatory T cells, Journal of Controlled Release, 2017; 267: 163-171. PMID: 29017854

Yun SP, Kam TI, Panicker N, Kim SM, Oh U, Park SH, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S*, Dawson TM*, Ko HS*, Block of A1 astrocyte conversion is neuroprotective in models of Parkinson’s disease, Nature Medicine, 2018 PMID: 29892066

Activities & Honors


  • NRC Associateship (NIH/NIST Fellowship, National Academy of Sciences, 2010
  • WMIC travel award, 2009
  • NRC Associateship (Fellowship), NIH/NIST, 2010
  • Pathway to Independence Award (K99/R00), National Academy of Sciences NIH, 2011
  • Guest Editor, Theranostics, 2012
  • Pilot Project Award, CCNE, 2013
  • Maryland Stem Cell Commission Grant, JHU, 2013
  • Career Development Award 2014, Department of Defense
  • Investigator-Initiated Research Award 2015, Department of Defense
  • Maryland Innovation Initiative Award 2016
  • Edward N. and Della L. Thome Memorial Foundation Award
  • 2017 Highly Cited Researchers (Clarivate Analytics)
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