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Shenghan Lai, M.D., M.P.H.

Photo of Dr. Shenghan Lai, M.D., M.P.H.
  • Professor of Pathology

Research Interests

Data mining; Drug abuse; Disease disparities in minorities; Cardiovascular consequences of HIV infection and cocaine abuse; HIV prevention and intervention; Infectious disease epidemiology ...read more

Background

Dr. Shenghan Lai is a professor of pathology, radiology, psychiatry, epidemiology and medicine at the Johns Hopkins University School of Medicine. His research interests include infectious disease epidemiology, HIV prevention and intervention, cardiovascular consequences of HIV infection and cocaine abuse, disease disparities in minorities, subclinical atherosclerosis, drug abuse, statistical modeling and data mining.

Dr. Lai earned his M.D. from Peking Union Medical College, China. He also completed his M.P.H. at the Uniformed Services University of the Health Sciences in Bethesda, Maryland.

In 1999, Dr. Lai received a NIH grant (R01DA12777) to investigate the effects of HIV infection and cocaine use on coronary calcification (subclinical atherosclerosis). That was the first NIH-funded to investigate HIV/cocaine-associated cardiovascular comorbidity in the US. Since then, six NIDA-funded studies were conducted by his research team and a cohort of study participants (N= approximately 1,500, 40% were women), with/without HIV infection, with/without ART and with/without cocaine use, has been established and followed up in Baltimore, Maryland for almost 20 consecutive years. He has more than 250 peer-reviewed publications and numerous book chapters.

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Titles

  • Professor of Pathology
  • Joint Appointment in Medicine
  • Joint Appointment in Psychiatry and Behavioral Sciences
  • Professor of Radiology and Radiological Science

Departments / Divisions

Centers & Institutes

Education

Degrees

  • M.P.H., Uniformed Services University of the Health Sciences (Bethesda) (Maryland) (1987)
  • M.D., Peking Union Medical College (China) (1985)

Research & Publications

Research Summary

Dr. Lai’s research interests include infectious disease epidemiology, HIV prevention and intervention, cardiovascular consequences of HIV infection and cocaine abuse, disease disparities in minorities, drug abuse, statistical modeling and data mining.

Selected Publications

Lai H, Stitzer M, Treisman G, Moore, R, Brinker J, Gerstenblith, Kickler T, Li J, Chen S, Fishman E, Lai S. Cocaine Abstinence and Reduced Use are Associated with Lowered Marker of Endothelial Dysfunction in Africa Americans: A Preliminary Study. J Addict Med 2015 Jul-Aug;9(4):331-9.

Rodriguez K, Kwan AC, Lai S, Lima JAC, Vigneault D, Sandfort V, Pattanayak P, Ahlman MA, Mallek M, Sibley CT, Bluemke DA. Coronary plaque burden by coronary CT angiography in asymptomatic men and women. Radiology 2015 June 2: 142551 [Epub ahead of print]

Lai S, Gerstenblith G, Li J, Zhu H, Bluemke DA, Liu C-Y, Zimmerman SL, Chen S, Lai H, Treisman G. Chronic Cocaine Use and Its Association with Myocardial Steatosis Evaluated by 1H Magnetic Resonance Spectroscopy in African Americans. J Addict Med 2015 Jan-Feb 9(1):31-9.

Liu CY, Bluemke DA, Gerstenblith G, Zimmerman SL, Li J, Zhu H, Lai S, Lai H. Reference Values of Myocardial Structure, Function and Tissue Composition by Cardiac Magnetic Resonance in Healthy African Americans at 3T and their Relations to Serologic and Cardiovascular Risk Factors. Am J Cardiol 2014 Sep1;114(5): 789-95.

Schuhbaeck A, Dey D, Otaki Y, Slomka P, Kral B, Achenbach S, Berman DS, Fishman E, Lai S, Lai H. Interscan Reproducibility of Quantitative Coronary Plaque Volume and Composition from CT Coronary Angiography using an Automated Method. Eur Radiol 2014 Sep; 24(9):2300-8.

Alegria M, Vera M, Shrout P, Canino G, Lai S, Albizu C, Marin H, Pena M, Rusch D. "Understanding hard-core drug use among urban Puerto Rican women in high-risk neighborhoods." Addict Behav 2004;29(4):643-64.

Ren S, Yang S, Lai S. "Intraclass Correlation Coefficients and Bootstrap Methods of Hierarchical Binary Outcomes." Stat Med 2004, accepted.

Tong W, Lima JA, Meng Q, Flynn E, Lai S. "Long-term cocaine use and cardiac diastolic dysfunction: an echocardiographic study." Int J Cardiol 2004;97:25-28.

Tong W, Lai H, Yang C, Ren S, Dai S, Lai S. "Age, gender and metabolic syndrome-related coronary heart disease in US adults." Int J Cardiol 2004; accepted.

Lima JA, Desai MY, Steen H, Warren WP, Gautam S, Lai S. "Statin-induced cholesterol lowering and plaque regression after 6 months of magnetic resonance imaging-monitoring therapy." Circulation 2004; 110(16):2336-41.

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