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School of Medicine
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Paul Talalay, D.Sc., M.D.
Professor of Pharmacology and Molecular Sciences
Research Interests: Molecular mechanisms involved in chemoprotection against cancer
- Professor of Pharmacology and Molecular Sciences
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Research & Publications
Chemoprotection against cancer: The susceptibility of animals and their cells to the mutagenic and neoplastic effects of chemical carcinogens and reactive oxygen intermediates depends on the balance between the activities of enzymes involved in the metabolic activation and inactivation (detoxication) of these agents. The activities of these enzymes are regulated by a wide variety of chemical agents and these modulations result in protection against cancer. We have developed animal and cell culture systems for analysis of the molecular signals that regulate detoxication enzymes. With the help of these systems, we have identified and isolated from edible plants (e.g., vegetables) potent enzyme inducers. These minor dietary constituents block chemical carcinogenesis. Biochemical, molecular and cell biological techniques are being used to develop strategies for reducing the risk of developing cancer by identifying phytochemical enzyme inducers in edible plants and evaluating their efficacy in cells, animals, and humans.
Lab Website: Paul Talalay Laboratory
Selected PublicationsView all on Pubmed
Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2399-403. PMID: 1549603
Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50. PMID: 8159717
Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72. PMID: 9294217
Prestera T, Holtzclaw WD, Zhang Y, Talalay P. Chemical and molecular regulation of enzymes that detoxify carcinogens. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2965-9. PMID: 8385353
Posner GH, Cho CG, Green JV, Zhang Y, Talalay P. Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enzymes. J Med Chem. 1994 Jan 7;37(1):170-6. PMID: 8289191
Contact for Research Inquiries
Wood Basic Science Building
725 N. Wolfe St
Baltimore, MD 21205 map
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