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Patricia Ann Ramaley Brunker, D.Phil., M.D., M.S.
Assistant Professor of Pathology
Languages: English, French, Spanish
Research Interests: Transfusion medicine; Alloimmunization
Dr. Patricia Brunker is an assistant professor of pathology at the Johns Hopkins University School of Medicine. Her area of clinical expertise is transfusion medicine.
Dr. Brunker’s research explores the genetics of the basis of alloimmunization. These projects include the evaluation of rapid-responder and non-responder status in pregnancy and family studies of alloimmunization including microchimerism analysis.
Dr. Brunker received her medical degree from Brown University Medical School. She completed an internship in general surgery and her residency in anatomic and clinical pathology at Brigham and Women's Hospital. She has a masters in biological anthropology and research doctorate in human genetics from the University of Oxford, U.K. She completed a clinical fellowship in transfusion medicine at The Johns Hopkins Hospital and a research postdoc in Rh genetics in the Department of Transfusion Medicine at the National Institutes of Health.
Dr. Brunker is certified in transfusion medicine and anatomic and clinical pathology by the American Board of Pathology. She also serves as the regional medical director for the American Red Cross Blood Services Division in the Greater Chesapeake & Potomac Region.
- Assistant Professor of Pathology
- MD, Brown University Medical School (2003)
- Brigham and Women's Hospital / Anatomic and Clinical Pathology (2008)
- Johns Hopkins University School of Medicine / Transfusion Medicine (2009)
- American Board of Pathology / Anatomic & Clinical Pathology (2008)
- American Board of Pathology / Pathology-Transfusion Med (2010)
Research & Publications
Dr. Brunker is using molecular characterization of patients and blood products to inform a patient-centered and individualized approach to transfusion medicine.
Projects in this area include increased utilization and outcomes research in molecular testing, including weak and partial Rh testing, cell-free, fetal DNA and real-time PCR. Dr. Brunker evaluates rapid-responder and non-responder status in pregnancy and also conducts family studies of alloimmunization, including microchimerism analysis, in order to gain a better understanding of the genetics of the basis of alloimmunization.
Brunker, PA. "Chimerism in transfusion medicine." Chimerism, 4(4). 2013.
Brunker, PA, Flegel, WA. "Scianna: the lucky 13th blood group system." Immunohematology/American Red Cross. 27(2), 41. 2011
Leider, JP, Brunker, PA, Ness, PM. "Convalescent transfusion for pandemic influenza: preparing blood banks for a new plasma product?" Transfusion. 50(6), 1384-1398. 2010
Ramaley, PA, French, N, Kaleebu, P, Gilks, C, Whitworth, J, Hill, AV. "HIV in Africa: chemokine-receptor genes and AIDS risk." Nature. 417(6885), 140-140. 2002
Hellier, S, Frodsham, AJ, Hennig, BJ, Klenerman, P, Knapp, S, Ramaley, P, Satsangi J, Wright M, Zhang L, Thomas HC, Thursz M, Hill AV. "Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection." Hepatology, 38(6), 1468-1476. 2003