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Robert Norman Cole, M.S., Ph.D.
Director, Mass Spectrometry and Proteomics Facility
Assistant Professor of Biological Chemistry
Research Interests: Mass spectrometry strategies to characterize proteins and their modifications in malnutrition, neurological diseases and cancer
Dr. Robert Cole is an assistant professor of biological chemistry at the Johns Hopkins School of Medicine. His research focuses on mass spectrometry strategies to characterize proteins and their modifications in malnutrition, neurological diseases and cancer. Dr. Cole serves as the director of the Mass Spectrometry and Proteomics Facility for the Johns Hopkins University School of Medicine and director of the Mass Spectrometry Core for the Johns Hopkins Kimmel Cancer Center.
Dr. Cole received his undergraduate degree in zoology/physiology from the University of Massachusetts, Amherst. He earned his M.S. in biology/physiological ecology from the University of South Carolina and his Ph.D. in physiology/neuroscience from Michigan State University. He completed postdoctoral training in glycobiology/neuroscience at the University of Alabama at Birmingham and the Johns Hopkins School of Medicine. Dr. Cole joined the Johns Hopkins faculty in 1998.
He is a member of the American Society for Mass Spectrometry, and his work has been recognized with a National Research Service Award from the National Institutes of Health.
- Director, Mass Spectrometry and Proteomics Facility
- Assistant Professor of Biological Chemistry
Departments / Divisions
- B.S., University of Massachusetts (Amherst) (Massachusetts) (1980)
- M.S., University of South Carolina (Columbia) (South Carolina) (1983)
- Ph.D., Michigan State University (Michigan) (1992)
Johns Hopkins School of Medicine, Baltimore, MD, 1998, Glycobiology/Neuroscience; University of Alabama at Birmingham, Birmingham, AL, 1997, Glycobiology/Neuroscience
Research & Publications
Dr. Cole's research focuses on mass spectrometry strategies to characterize proteins and their modifications in malnutrition, neurological diseases and cancer.
The proteomics core provides extensive mass spectrometry services for analyzing protein mixtures and purified proteins. Protein profiling using two-dimensional gel analysis and fluorescent labeling is also offered.
Core Facility: Mass Spectometry and Proteomics Core
Zhang Y, Dayalan Naidu S, Samarasinghe K, Van Hecke GC, Pheely A, Boronina TN, Cole RN, Benjamin IJ, Cole PA, Ahn YH, Dinkova-Kostova AT. "Sulphoxythiocarbamates modify cysteine residues in HSP90 causing degradation of client proteins and inhibition of cancer cell proliferation." Br J Cancer. 2014 Jan 7;110(1):71-82. doi: 10.1038/bjc.2013.710. Epub 2013 Dec 5.
Cole RN, Ruczinski I, Schulze K, Christian P, Herbrich S, Wu L, Devine LR, O'Meally RN, Shrestha S, Boronina TN, Yager JD, Groopman J, West KP Jr. "The plasma proteome identifies expected and novel proteins correlated with micronutrient status in undernourished Nepalese children." J Nutr. 2013 Oct;143(10):1540-8. doi: 10.3945/jn.113.175018. Epub 2013 Aug 21.
Kunjithapatham R, Geschwind JF, Rao PP, Boronina TN, Cole RN, Ganapathy-Kanniappan S. "Systemic administration of 3-bromopyruvate reveals its interaction with serum proteins in a rat model." BMC Res Notes. 2013 Jul 17;6(1):277. [Epub ahead of print]
Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B. "The cardiac acetyl-lysine proteome." PLoS One. 2013 Jul 2;8(7):e67513. doi: 10.1371/journal.pone.0067513. Print 2013.
Herbrich SM, Cole RN, West KP Jr, Schulze K, Yager JD, Groopman JD, Christian P, Wu L, O'Meally RN, May DH, McIntosh MW, Ruczinski I. "Statistical inference from multiple iTRAQ experiments without using common reference standards." J Proteome Res. 2013 Feb 1;12(2):594-604. doi: 10.1021/pr300624g. Epub 2013 Jan 16.
Activities & Honors
- Jack Hoffert Memorial Award, Michigan State University, 1992
- National Research Service Award, National Institutes of Health, 1993 - 1995
- American Society for Mass Spectrometry, 2002
- Greater Baltimore-Washington Area Mass Spectrometry Discussion Group, 2002 - 2004
Member and Co-Chair
- Society for Glycobiology, 1992 - 2000
- Society of Neuroscience, 1987 - 2000
- Research Technology Program Review Committee for Laboratory of Proteomics & Analytical Technologies (LPAT), National Cancer Institute
- Analytical Pharmacology Core Steering Committee (APCSC), The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine
- Proteomics Annual Advisory Board, Georgetown University Medical Center