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Cory Brayton, D.V.M.

Cory Flagg Brayton, D.V.M.

Photo of Dr. Cory Brayton, D.V.M.
  • Director, Phenotyping Core
  • Associate Professor of Molecular and Comparative Pathobiology

Expertise

Pathology and Laboratory Medicine

Research Interests

Phenotyping; Genetically Engineered Mice; Experimental Pathology; Toxicologic Pathology; Cancer; Infectious Disease; Drug Discovery and Development; GLP ...read more

Background

Cory Brayton, DVM, Diplomate ACLAM, Diplomate ACVP, is an associate professor of molecular and comparative pathobiology at the Johns Hopkins University School of Medicine. Her research focuses on phenotyping and pathology in diverse translational research areas, including cancer, aging, immunology, infectious diseases. Dr. Brayton serves as the director of the Phenotyping Core.

Dr. Brayton is a diplomate of the American College of Laboratory Animal Medicine (ACLAM), and of the American College of Veterinary Pathologists (ACVP). She served as president of ACVP in 2014.

Dr. Brayton’s expertise includes the spontaneous pathology and genetics of research mice, experimental pathology, and the impacts of infectious and other environmental factors on pathology, disease expression, and other phenotypes in diverse research models.

She received her DVM from Cornell University, and did postdoctoral research and pathology training in New York City at the Animal Medical Center, Cornell University Medical College, and The Rockefeller University. At The Rockefeller University (1989-1992), she became specifically interested in genetically engineered mice (GEM) models in translational research, and in their pathology and characterization (phenotyping).

At the Hospital for Special Surgery (1992-1998), she was attending veterinarian and Director of the Facility for Comparative Studies. At Baylor College of Medicine (1998-2004), she headed the Comparative Pathology Laboratory, and was responsible for health surveillance and diagnostic pathology for a diverse research population including more than 150,000 mice. She also served as attending veterinarian, and associate director of the Center for Comparative Medicine. In 2004, she moved to Johns Hopkins to develop the Phenotyping Core.

Dr. Brayton’s primary teaching interest is to improve and promote understanding of model organism biology and pathology, especially as it is relevant to valid and predictive translational biomedical research. She has developed, directed, co-directed, and lectured in symposia, conferences, courses and workshops relevant to phenotyping, pathology, genetics of mice and other laboratory animals, in the US and abroad. She has authored and coauthored books, chapters and invited reviews on mouse biology and pathology.

At JHU, she has developed symposia and courses including 680.712 Phenotyping for Functional Genetics (Mouse Pathobiology and Phenotyping Short Course), and participates as faculty and lecturer in 680.701 Principles of Animal Pathology and Genetically Engineered Mice; 680.702 LAM/PATH Integrated Problem Solving; 690.707 Experimental Design and Scientific Writing; 680.711 Comparative Pathology Conference; Toxicological Pathology, Bloomberg School of Public Health, and other courses.

...read more

Titles

  • Director, Phenotyping Core
  • Associate Professor of Molecular and Comparative Pathobiology

Departments / Divisions

  • Molecular and Comparative Pathobiology

Centers & Institutes

Research & Publications

Research Summary

Dr. Brayton’s primary research role, as collaborator and phenotyping core director, is in model selection, study design, data analysis, and pathology to achieve valid and predictive translational biomedical research. Research outcomes (phenotypes) represent the intended and unintended consequences of experimental interventions, as well as often under-recognized nature (genetic) and nurture (environmental) influences on the model system. Dr. Brayton’s expertise includes the spontaneous pathology and genetics of research mice, as well as experimental pathology, and the impacts of infectious and other environmental factors on pathology, disease expression and other phenotypes in diverse species.  She has published on comparative cardiovascular, pulmonary, renal, musculoskeletal, hematopoietic, neural and ophthalmic pathology, comparative carcinogenesis, autoimmune diseases and infectious diseases in mice and other species.

Contact her to discuss experimental design, phenotyping, collaboration or research pathology needs.

Lab

The Phenotyping Core facilitates interdisciplinary phenotyping and translational research collaborations, and offers preclinical research pathology support and collaboration. Dr. Brayton works with JHU faculty and cores in multidisciplinary research in diverse research areas.

Core Facility: Phenotyping (and Pathology) Core (Phenocore)

Technology Expertise Keywords

Pathology; Phenotyping; Mice; Cancer; Ageing; Infectious Disease

Selected Publications

View all on Pubmed

Brayton CF, Treuting PM, and Ward JM. Pathobiology of Aging Mice and GEM: Background Strains and Experimental Design. Vet Pathol. 2012; 49:85-105. Invited Review.

Zeiss CJ and Brayton CF. Immune responses to the real world. (Nature) Lab Anim (NY). 2017. 47(1): 13-14. PMID: 29297473

Brayton C. In Defense of Parity, Females, and Pathology in Research. Vet Pathol. 2017. 54(5): 731-733. PMID: 11780111

Roediger B, Lee Q, Tikoo S, Cobbin JCA, Henderson JM, Jormakka M, O'Rourke MB, Padula MP, Pinello N, Henry M, Wynne M, Santagostino S, Brayton C, Rasmussen L, Lisowski L, Tay SS, Harris DC, Bertram JF, Dowling JP, Bertolino P, Lai JH, Wu W1, Bachovchin WW, Wong JJ, Gorrell MD, Shaban B, Holmes EC, Jolly CJ, Monette S, Weninger W. An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell. 2018. 175(2): 530-543 e524. PMID: 30220458

Radaelli E, Santagostino SF, Sellers RS, and Brayton CF. Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research. ILAR J. 2019 59(3): 1-36.

Contact for Research Inquiries

Phone: 410-502-3050

Academic Affiliations & Courses

Graduate Program Affiliation

Graduate Program Comparative Pathology in Translational Science

Courses and Syllabi

  • Phenotyping for Functional Genetics (Mouse Pathobiology and Phenotyping Short Course) (680.712)
    2007
  • Comparative Pathology Tuesday slide conference

Activities & Honors

Honors

  • Outstanding Leadership, Baylor College of Medicine, 2001
  • Outstanding Service, Charles Louis Davis Foundation for the Advancement of Veterinary and Comparative Pathology, 2001
  • Robert Ferrell Distinguished Lecturer Award, Charles Louis Davis Foundation for the Advancement of Veterinary and Comparative Pathology, 2013
  • President Elect, American College of Veterinary Pathologists (ACVP), 2013 - 2014
  • President, American College of Veterinary Pathologists (ACVP), 2014 - 2015
  • Edgar Hartley Kettle Distinguished Speaker Award, Royal College of Pathologists, British Society of Toxicological Pathologists, 2016
  • Pravin N. Bhatt Award Scientific Investigator Award, AALAS American Association for Laboratory Science, 2018

Memberships

  • American Association for Laboratory Animal Science (AALAS), 1990

    member since 1990; Editorial Board 'JAALAS', 'Comparative Medicine' since 2002.

  • American College of Laboratory Animal Medicine (ACLAM), 1997

    Diplomate since 1997; Examination Committee 2000-2003.

  • American College of Veterinary Pathologists (ACVP), 1997

    Diplomate since 1997; Council (elected) 2009-2012; President Elect 2013; President 2014.

  • American Veterinary Medical Association, 1985
    member
  • Charles Louis Davis Foundation for the Advancement of Veterinary and Comparative Pathology

    Board of Directors; Faculty of Discussants since 2000.

  • Institute for Laboratory Animal Research ILAR (National Academy of Sciences Division on Earth and Life Studies of the National Research Council), 2012 - 2016

    Councillor since 2012; co Editor in Chief 'ILAR Journal' since 2012.

  • International Council for Laboratory Animal Science (ICLAS), 2014

    US representative since 2014

  • International Mammalian Genome Society (IMGS), 2013

    Editorial Board, Mammalian Genome, since 2013

  • Society of Toxicologic Pathology (STP), 2006

    Member since 2006; Program committee 2014, 2016; Editorial board "Toxicologic Pathology' since 2018.

Professional Activities

  • Diplomate, American College of Laboratory Animal Medicine, 1997
  • Diplomate, American College of Veterinary Pathologists, 1997
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