Dr. Lim's primary research interest involves immune-based therapies against brain tumors. His research focuses on understanding the mechanisms of immune evasion by primary brain tumors with the goal of translation to novel therapies against gliomas. Dr. Lim also performs clinical research. He publishes extensively in radiosurgery and also has interests in brain tumor clinical trials for which he works closely with the neuro-oncologists in a team approach.
Dr. Lim is the Director of the Brain Cancer Immunology Laboratory at Johns Hopkins. His laboratory explores mechanisms of immune resistance and novel therapies for brain tumors. In addition, his laboratory performs translational studies to develop the next generation of clinical trials.
Dr. Lim is the co-principal investigator of the Johns Hopkins Comprehensive Subependymoma and Ependymoma Research Center. This research center conducts basic science, translational and clinical practice research with the goals of optimizing current treatment options and developing new therapies that will positively impact the care and lives of patients with subependymomas and ependymomas, primary central nervous system (CNS) brain tumors
Clinical Trial Keywords
EGFRvIII, Vaccine, Oncophage
STUDY NAME: SRS (Stereotactic Radiosurgery) Plus Ipilimumab
- SUMMARY: This research is being done to look at the safety of using stereotactic radiosurgery (SRS) and Ipilimumab together to treat melanoma that has spread to the brain or spine. Both Ipilimumab and SRS are used alone for the treatment of melanoma that has spread. Standard of care uses both of these treatments but are not at the same time. By using them together, we expect better treatment of melanoma, but there might be an increase in side effects. This research study plans to look at the timing and sequence of the SRS and the Ipilumumab. There is also an option to adjust the doses of the Ipilumumab if too many side effects are seen. Ipilimumab is approved by the Food and Drug Administration (FDA) for the treatment of melanoma that has spread throughout the body. It works by activating your immune system to fight off cancer. Stereotactic radiosurgery (SRS) is approved by the FDA for the treatment of melanoma in the brain or spine. It uses radiation to treat tumors without needing to cut or use stitches. The combination of SRS and Ipilimumab in this research study is investigational. The word "investigational" means that this combination is not approved by the FDA.
STUDY NAME: A Randomized Study of Nivolumab or Nivolumab Combined With Ipilimumab Versus Bevacizumab in Adult Subjects With Recurrent Glioblastoma(GBM)(CheckMate 143)
- SUMMARY: The purpose of the study is to understand the safety, tolerability and efficacy of Nivolumab as a single agent or in combination with Ipilimumab versus Bevacizumab in patients diagnosed with Recurrent Glioblastoma (GBM).
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1.Factors associated with survival for patients with glioblastoma with poor pre-operative functional status.
Chaichana KL, Martinez-Gutierrez JC, De la Garza-Ramos R, Weingart JD, Olivi A, Gallia GL, Lim M, Brem H, Quinones-Hinojosa A.
J Clin Neurosci. 2013 Jun;20(6):818-23. doi: 10.1016/j.jocn.2012.07.016. Epub 2013 Apr 29.
2.Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection.
Chen L, Guerrero-Cazares H, Ye X, Ford E, McNutt T, Kleinberg L, Lim M, Chaichana K, Quinones-Hinojosa A, Redmond K.
Int J Radiat Oncol Biol Phys. 2013 Mar 26. doi:pii: S0360-3016(13)00182-X. 10.1016/j.ijrobp.2013.02.014. [Epub ahead of print]
3.Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas.
Zeng J, See AP, Phallen J, Jackson CM, Belcaid Z, Ruzevick J, Durham N, Meyer C, Harris TJ, Albesiano E, Pradilla G, Ford E, Wong J, Hammers HJ, Mathios D, Tyler B, Brem H, Tran PT, Pardoll D, Drake CG, Lim M.
Int J Radiat Oncol Biol Phys. 2013 Jun 1;86(2):343-9. doi: 10.1016/j.ijrobp.2012.12.025. Epub 2013 Feb 22.
4.Three-dimensional amide proton transfer MR imaging of gliomas: Initial experience and comparison with gadolinium enhancement.
Zhou J, Zhu H, Lim M, Blair L, Quinones-Hinojosa A, Messina SA, Eberhart CG, Pomper MG, Laterra J, Barker PB, van Zijl PC, Blakeley JO.
J Magn Reson Imaging. 2013 Feb 25. doi: 10.1002/jmri.24067. [Epub ahead of print]
5.Vaccine strategies for glioblastoma: progress and future directions.
Jackson C, Ruzevick J, Brem H, Lim M.
Immunotherapy. 2013 Feb;5(2):155-67. doi: 10.2217/imt.12.155.
6.Deep venous thrombosis and pulmonary embolisms in adult patients undergoing craniotomy for brain tumors.
Chaichana KL, Pendleton C, Jackson C, Martinez-Gutierrez JC, Diaz-Stransky A, Aguayo J, Olivi A, Weingart J, Gallia G, Lim M, Brem H, Quinones-Hinojosa A.
Neurol Res. 2013 Mar;35(2):206-11. doi: 10.1179/1743132812Y.0000000126. Epub 2012 Dec 13.
7.Glycerol rhizotomy and radiofrequency thermocoagulation for trigeminal neuralgia in multiple sclerosis.
Bender M, Pradilla G, Batra S, See AP, James C, Pardo CA, Carson BS, Lim M.
J Neurosurg. 2013 Feb;118(2):329-36. doi: 10.3171/2012.9.JNS1226. Epub 2012 Nov 2.
8.The role of STAT3 activation in modulating the immune microenvironment of GBM.
See AP, Han JE, Phallen J, Binder Z, Gallia G, Pan F, Jinasena D, Jackson C, Belcaid Z, Jeong SJ, Gottschalk C, Zeng J, Ruzevick J, Nicholas S, Kim Y, Albesiano E, Pardoll DM, Lim M.
J Neurooncol. 2012 Dec;110(3):359-68. doi: 10.1007/s11060-012-0981-6. Epub 2012 Oct 25.
9.Multiple resections for patients with glioblastoma: prolonging survival.
Chaichana KL, Zadnik P, Weingart JD, Olivi A, Gallia GL, Blakeley J, Lim M, Brem H, Quiones-Hinojosa A.
J Neurosurg. 2013 Apr;118(4):812-20. doi: 10.3171/2012.9.JNS1277. Epub 2012 Oct 19.
10.Perspectives on key articles in neurosurgery.
Lim M, Sherman JH, Wang VY, Smith ZA, Cho JM, Colen CB, Kim CY, Zada G, Li G, Yang I.
Surg Neurol Int. 2012;3:58. doi: 10.4103/2152-7806.96869. Epub 2012 May 31. No abstract available.
11.Clinical trials with immunotherapy for high-grade glioma.
Ruzevick J, Jackson C, Phallen J, Lim M.
Neurosurg Clin N Am. 2012 Jul;23(3):459-70. doi: 10.1016/j.nec.2012.04.003. Epub 2012 Jun 8. Review.
12.Potential role for STAT3 inhibitors in glioblastoma.
Jackson C, Ruzevick J, Amin AG, Lim M.
Neurosurg Clin N Am. 2012 Jul;23(3):379-89. doi: 10.1016/j.nec.2012.04.002. Epub 2012 Jun 5. Review.
13.Subependymoma: clinical features and surgical outcomes.
Jain A, Amin AG, Jain P, Burger P, Jallo GI, Lim M, Bettegowda C.
Neurol Res. 2012 Sep;34(7):677-84. doi: 10.1179/1743132812Y.0000000064. Epub 2012 Jun 28. Review.
14.The Transconjunctival Transorbital Approach: A Keyhole Approach to the Midline Anterior Skull Base.
Raza SM, Quinones-Hinojosa A, Lim M, Boahene KD.
World Neurosurg. 2012 Jun 19. [Epub ahead of print]
15.Postoperative Anticoagulation in Patients with Mechanical Heart Valves Following Surgical Treatment of Subdural Hematomas.
Amin AG, Ng J, Hsu W, Pradilla G, Raza S, Quinones-Hinojosa A, Lim M.
Neurocrit Care. 2012 Apr 13. [Epub ahead of print]
16.Seizure control for patients undergoing meningioma surgery.
Chaichana KL, Pendleton C, Zaidi H, Olivi A, Weingart JD, Gallia GL, Lim M, Brem H, Quiones-Hinojosa A.
World Neurosurg. 2013 Mar-Apr;79(3-4):515-24. doi: 10.1016/j.wneu.2012.02.051. Epub 2012 Mar 30.
17.The predictive value of serum myeloperoxidase for vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Lim M, Bower RS, Wang Y, Sims L, Bower MR, Camara-Quintana J, Li G, Cheshier S, Harsh GR 4th, Steinberg GK, Guccione S.
Neurosurg Rev. 2012 Jul;35(3):413-9; discussion 419. doi: 10.1007/s10143-012-0375-4. Epub 2012 Feb 28.
18.Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment.
Jackson C, Ruzevick J, Phallen J, Belcaid Z, Lim M.
Clin Dev Immunol. 2011;2011:732413. doi: 10.1155/2011/732413. Epub 2011 Dec 10. Review.
19.Stereotactic radiosurgery of cranial arteriovenous malformations and dural arteriovenous fistulas.
See AP, Raza S, Tamargo RJ, Lim M.
Neurosurg Clin N Am. 2012 Jan;23(1):133-46. doi: 10.1016/j.nec.2011.09.011. Review.
20.Effectiveness of repeat glycerol rhizotomy in treating recurrent trigeminal neuralgia.
Bender M, Pradilla G, Batra S, See A, Bhutiani N, James C, Carson BS, Lim M.
Neurosurgery. 2012 May;70(5):1125-33; discussion 1133-4. doi: 10.1227/NEU.0b013e31823f5eb6.