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Mahendra Damarla, M.D.

Photo of Dr. Mahendra Damarla, M.D.
  • Associate Professor of Medicine


Acute Lung Injury (ALI), Pulmonary Disease and Critical Care Medicine

Research Interests

Vascular biology

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Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
4940 Eastern Avenue
Baltimore, MD 21224 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-3467
601 N. Caroline St.
Baltimore, MD 21287 map

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-3467
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map


Dr. Mahendra Damarla is an assistant professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include acute lung injury, pulmonary disease and critical care medicine. 

Dr. Damarla earned his M.D. from the University of Louisville School of Medicine. He completed his residency at St. Elizabeth Medical Center and performed a fellowship in pulmonary medicine at Johns Hopkins.

His research interests include vascular biology. more


  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD, University of Louisville School of Medicine (2001)


  • St Elizabeth's Medical Center / Internal Medicine (2005)


  • Johns Hopkins University School of Medicine / Pulmonary Medicine (2008)

Board Certifications

  • American Board of Internal Medicine / Critical Care Medicine (2012)
  • American Board of Internal Medicine / Pulmonary Disease (2009)

Research & Publications

Selected Publications

View all on Pubmed

Kim BS, Serebreni L, Fallica J, Hamdan O, Wang L, Johnston L, Kolb T, Damarla M, Damico R, Hassoun PM. "Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia." PLoS One. 2015 Apr 1;10(4):e0124189. doi: 10.1371/journal.pone.0124189. eCollection 2015.

Hikmat F, Pearse DB, Damarla M. "A presentation of massive hemoptysis in a patient with Churg-Strauss syndrome." Can Respir J. 2014 November/December;21(6):337-340. Epub 2014 Sep 25.

Fallica J, Boyer L, Kim B, Serebreni L, Varela L, Hamdan O, Wang L, Simms T, Damarla M, Kolb TM, Bucala R, Mitzner W, Hassoun PM, Damico R. "Macrophage migration inhibitory factor is a novel determinant of cigarette smoke-induced lung damage." Am J Respir Cell Mol Biol. 2014 Jul;51(1):94-103. doi: 10.1165/rcmb.2013-0371OC.

Aggarwal NR, Chau E, Garibaldi BT, Mock JR, Sussan T, Rao K, Rao K, Menon AG, D'Alessio FR, Damarla M, Biswal S, King LS, Sidhaye VK. "Aquaporin 5 regulates cigarette smoke induced emphysema by modulating barrier and immune properties of the epithelium." Tissue Barriers. 2013 Oct 1;1(4):e25248. doi: 10.4161/tisb.25248. Epub 2013 Jun 3.

Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. "Mitogen-activated protein kinase-activated protein kinase 2 mediates apoptosis during lung vascular permeability by regulating movement of cleaved caspase 3." Am J Respir Cell Mol Biol. 2014 May;50(5):932-41. doi: 10.1165/rcmb.2013-0361OC.

Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. MK2 Mediates Apoptosis During Lung Vascular Permeability by Regulating Movement of Cleaved Caspase 3. Am J Respir Cell Mol Biol. 2013 Dec 4. [Epub ahead of print] PMID: 24304496

Kim BS, Serebreni L, Hamdan O, Wang L, Parniani A, Sussan T, Scott Stephens R, Boyer L, Damarla M, Hassoun PM, Damico R. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free Radic Biol Med. 2013 Jul;60:336-46. doi: 10.1016/j.freeradbiomed.2013.01.023. Epub 2013 Feb 4. PMID: 23380026

Shah NG, Tulapurkar ME, Damarla M, Singh IS, Goldblum SE, Shapiro P, Hasday JD. Febrile-range hyperthermia augments reversible TNF-α-induced hyperpermeability in human microvascular lung endothelial cells. Int J Hyperthermia. 2012;28(7):627-35. doi: 10.3109/02656736.2012.690547. Epub 2012 Jul 26. PMID: 22834633

Rentsendorj O, Damarla M, Aggarwal NR, Choi JY, Johnston L, D'Alessio FR, Crow MT, Pearse DB. Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L161-70. doi: 10.1152/ajplung.00073.2011. Epub 2011 May 13. PMID: 21571906

Damico R, Simms T, Kim BS, Tekeste Z, Amankwan H, Damarla M, Hassoun PM. p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor. Am J Respir Cell Mol Biol. 2011 Mar;44(3):323-32. doi: 10.1165/rcmb.2009-0379OC. Epub 2010 May 6. PMID: 20448056

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