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Amy Elizabeth DeZern, M.D., M.H.S.
Associate Professor of Oncology
Expertise: Acute Myeloid Leukemia (AML), Aplastic Anemia, Bone Marrow Failure, Bone Marrow Transplant, Medical Oncology, Myelodysplastic Syndromes (MDS), Paroxysmal Nocturnal Hemoglobinuria ...read more
Research Interests: The clinical investigation of novel approaches to diagnosis and therapy in bone marrow failure disorders and clonal hematopoiesis ...read more
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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
APPOINTMENT PHONE: 410-955-8964
401 N. Broadway Baltimore, MD 21231
Dr. Amy DeZern is a hematologist and medical oncologist at the Sidney Kimmel Comprehensive Cancer Center and is an Associate Professor of Oncology and Medicine at the Johns Hopkins University School of Medicine. She received her medical degree in 2005 from the Johns Hopkins University School of Medicine and her Master in Clinical Investigation (M.H.S.) from the Johns Hopkins Bloomberg School of Public Health. She completed residency training in internal medicine as well as fellowships in medical oncology and hematology at Johns Hopkins. Dr. DeZern sees patients at the Sidney Kimmel Comprehensive Cancer Center.
Dr. DeZern’s primary clinical and research interests are focused on bone marrow failure disorders. She has expertise in the diagnosis and treatment of myelodysplastic syndromes (MDS), aplastic anemia (AA), paroxysmal nocturnal hemoglobinuria (PNH), and other bone marrow failure syndromes as well as acute leukemias. She sees clinic patients weekly with these diagnoses as well as patients in need of bone marrow transplants for the same disorders. Dr. DeZern greatly enjoys taking care of patients with bone marrow failure and hematologic malignancies, and is dedicated to improving the care and outcomes of patients with these conditions. To that end, she is an active clinician scientist who specializes in clinical studies of diagnostics and therapeutics for marrow failure. She is the principal investigator of several clinical trials treating patients with severe aplastic anemia using a specialized bone marrow transplant regimen at Johns Hopkins as well as the PI of multiple other study protocols for novel therapeutics in MDS. Her work has resulted in multiple publications in the scientific literature and presentations at national meetings. She is also involved with the Aplastic Anemia and MDS International Foundation and the local PI of the MDS Clinical Research Consortium.
- Associate Professor of Oncology
- Associate Professor of Medicine
Centers & Institutes
- MD, Johns Hopkins University School of Medicine (2005)
- Johns Hopkins University School of Medicine / Internal Medicine (2008)
- Johns Hopkins University School of Medicine / Hematology and Oncology (2009)
- Johns Hopkins University School of Medicine / Oncology (2012)
Research & Publications
Clinical Trial Keywordsbone marrow translplants, Bone marrow failure disorders, Leukemia/Lymphoma
DeZern AE, Luznik L, Fuchs EJ, Jones RJ, Brodsky RA. Post-transplantation cyclophosphamide for GVHD prophylaxis in severe aplastic anemia. Bone Marrow Transplant. 201l; 46(7):1012-3. PMCID: PMC4161041.
DeZern AE, Pu J, McDevitt MA, Jones RJ, Brodsky RA. Burst-Forming Unit-Erythroid Assays (BFU-E) To Distinguish Cellular Bone Marrow Failure Disorders. Exp Hematol. 2013; 41(9):808-16. PMCID: PMC3769493.
DeZern AE, Symons HJ, Resar LS, Borowitz MJ, Armanios MY, Brodsky RA. Detection of paroxysmal nocturnal hemoglobinuria clones to exclude inherited bone marrow failure syndromes. Eur J Haematol 2014; 92(6):467-70. PMCID: PMC4161035.
DeZern AE, Uknis M, Mukhina GL, Saye J, Pu J, Brodsky RA. Complement blockade with a C1 esterase inhibitor in paroxysmal nocturnal hemoglobinuria. Exp Hematol. 2014; 42(10):857-861. PMCID: PMC4250431.
DeZern AE, William K, Zahurak M, Hand W, Stephens RS, King KE, Frank SM, Ness PM. Red Cell Transfusion Triggers in Acute Leukemia: A randomized pilot study. Transfusion. 2016. Accepted.