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Stephen Carl Mathai, M.D., M.H.S.

Photo of Dr. Stephen Carl Mathai, M.D., M.H.S.
  • Associate Professor of Medicine


Pulmonary Disease and Critical Care Medicine, Pulmonary Medicine

Research Interests

Scleroderma-associated pulmonary hypertension; Idiopathic pulmonary fibrosis; Pulmonary complications of connective tissue disease; Pulmonary hypertension

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The Johns Hopkins Hospital

Appointment Phone: 410-550-5864
1830 E. Monument Street
1830 Building 5th Floor Pulmonary
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-550-5864
601 N. Caroline St.
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-3467


Dr. Stephen Mathai is an associate professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pulmonary disease and critical care medicine.

Dr. Mathai earned his M.D. from Jefferson Medical College of Thomas Jefferson University. He completed his residency at Thomas Jefferson University Hospital and performed a fellowship in pulmonary and critical care medicine at Johns Hopkins. Dr. Mathai joined the Johns Hopkins faculty as an assistant professor of medicine in 2009.

His research interests include scleroderma-associated pulmonary hypertension, idiopathic pulmonary fibrosis and pulmonary complications of connective tissue disease. more


  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD, Sidney Kimmel Medical College of Thomas Jefferson University (1999)


  • Thomas Jefferson University Hospital / Medicine (2003)


  • Johns Hopkins University School of Medicine / Pulmonary and Critical Care Medicine (2008)

Board Certifications

  • American Board of Internal Medicine / Critical Care Medicine (2010)

Research & Publications

Selected Publications

View all on Pubmed

Chin K, Mathai SC. "Exercise echocardiography in connective tissue disease." J Am Coll Cardiol. 2015 Jul 28;66(4):385-7. doi: 10.1016/j.jacc.2015.05.038.

Kelemen BW, Mathai SC, Tedford RJ, Damico RL, Corona-Villalobos C, Kolb TM, Chaisson NF, Harris TH, Zimmerman SL, Kamel IR, Kass DA, Hassoun PM. "Right ventricular remodeling in idiopathic and scleroderma-associated pulmonary arterial hypertension: two distinct phenotypes." Pulm Circ. 2015 Jun;5(2):327-34. doi: 10.1086/680356.

Bourji KI, Khair RM, Damico RL, Kolb TM, Mathai SC, Hassoun PM. "Vascular receptor autoantibodies in pulmonary arterial hypertension." Am J Respir Crit Care Med. 2015 Mar 1;191(5):602. doi: 10.1164/rccm.201412-2267LE.

Matura LA, Ventetuolo CE, Palevsky HI, Lederer DJ, Horn EM, Mathai SC, Pinder D, Archer-Chicko C, Bagiella E, Roberts KE, Tracy RP, Hassoun PM, Girgis RE, Kawut SM. "Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension." Ann Am Thorac Soc. 2015 Mar;12(3):370-5. doi: 10.1513/AnnalsATS.201410-463OC. PMID: 25615959

Damico R, Kolb TM, Valera L, Wang L, Housten T, Tedford RJ, Kass DA, Rafaels N, Gao L, Barnes KC, Benza RL, Rand JL, Hamid R, Loyd JE, Robbins IM, Hemnes AR, Chung WK, Austin ED, Drummond MB, Mathai SC, Hassoun PM. "Serum endostatin is a genetically determined predictor of survival in pulmonary arterial hypertension." Am J Respir Crit Care Med. 2015 Jan 15;191(2):208-18. doi: 10.1164/rccm.201409-1742OC.

Dezube R, Terry P, Akulian J, Mathai SC, Boyle M, Khasab T, Yarmus L. Chronic expanding hematoma of the lung. Am J Respir Crit Care Med. 2013 Dec 1;188(11):e71. doi: 10.1164/rccm.201304-0723IM. No abstract available. PMID: 24289786

Bonner N, Abetz L, Meunier J, Sikirica M, Mathai SC. Development and validation of the living with pulmonary hypertension questionnaire in pulmonary arterial hypertension patients. Health Qual Life Outcomes. 2013 Oct 3;11:161. doi: 10.1186/1477-7525-11-161. PMID: 24088389

Khanna D, Gladue H, Channick R, Chung L, Distler O, Furst DE, Hachulla E, Humbert M, Langleben D, Mathai SC, Saggar R, Visovatti S, Altorok N, Townsend W, FitzGerald J, McLaughlin VV. Recommendations for screening and detection of connective tissue disease-associated pulmonary arterial hypertension. Arthritis Rheum. 2013 Dec;65(12):3194-201. doi: 10.1002/art.38172. PMID: 24022584

Tedford RJ, Mudd JO, Girgis RE, Mathai SC, Zaiman AL, Housten-Harris T, Boyce D, Kelemen BW, Bacher AC, Shah AA, Hummers LK, Wigley FM, Russell SD, Saggar R, Saggar R, Maughan WL, Hassoun PM, Kass DA. Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension. Circ Heart Fail. 2013 Sep 1;6(5):953-63. PMID: 23797369

Mathai SC, Wise RA, Puhan MA, Lam D. Reply from the authors. Am J Respir Crit Care Med. 2013 Mar 15;187(6):659. No abstract available. PMID: 23614142

Yarmus LB, Akulian JA, Gilbert C, Mathai SC, Sathiyamoorthy S, Sahetya S, Harris K, Gillespie C, Haas A, Feller-Kopman D, Sterman D, Lee HJ. Comparison of moderate versus deep sedation for endobronchial ultrasound transbronchial needle aspiration. Ann Am Thorac Soc. 2013 Apr;10(2):121-6. doi: 10.1513/AnnalsATS.201209-074OC. PMID: 23607840

Mathai SC. A look to the past, present, and future of pulmonary hypertension. Int J Clin Pract Suppl. 2013 May;(179):1. doi: 10.1111/ijcp.12173. No abstract available. PMID: 23578067

Mathai SC, Hassoun PM. Drs. Mathai and Hassoun reply. J Rheumatol. 2013 Jan;40(1):91. No abstract available. PMID: 23401876

Mathai SC. Solvitur ambulando…or maybe not? Chest. 2013 Feb 1;143(2):285-7. doi: 10.1378/chest.12-1819. No abstract available. PMID: 23381304

Shehata ML, Harouni AA, Skrok J, Basha TA, Boyce D, Lechtzin N, Mathai SC, Girgis R, Osman NF, Lima JA, Bluemke DA, Hassoun PM, Vogel-Claussen J. Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study. Radiology. 2013 Jan;266(1):114-22. doi: 10.1148/radiol.12111599. Epub 2012 Nov 14. PMID: 23151825

Activities & Honors

Professional Activities

  • Education Leader, Carol Johns (Pulmonary) Service, 2013

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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