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Venkataramana K Sidhaye, M.D.

Photo of Dr. Venkataramana K Sidhaye, M.D.
  • Associate Professor of Medicine


Internal Medicine, Pulmonary Medicine

Research Interests

Airway epithelial biology; Lung epithelial biology; Airway epithelial permeability; Aquaporins in the lung

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-550-5864
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-550-5864
601 N. Caroline St.
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
4940 Eastern Avenue
Baltimore, MD 21224 map


Dr. Venkataramana Sidhaye is an Associate professor of medicine at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include Pulmonary medicine with a research focus on basic mechanisms of COPD and Critical Care Medicine. 

Dr. Sidhaye serves as the associate director of the Physician Scientist pathway in the Osler Residency Program at Johns Hopkins.

She received her M.D. from the Feinberg School of Medicine at Northwestern University. She completed her residency at Northwestern and performed a fellowship in pulmonary and critical care medicine at Johns Hopkins.

Dr. Sidhaye's research interests include basic mechanisms of lung epithelial function in response to chronic exposures such as tobacco smoke, as well as other environmental exposures.  In addition, we are interested in epithelial responses to infectious insults. more


  • Associate Professor of Medicine

Departments / Divisions



  • MD, Northwestern University Feinberg School of Medicine (1998)


  • Northwestern University Feinberg School of Medicine / Internal Medicine (2002)


  • Johns Hopkins University School of Medicine / Pulmonary and Critical Care Medicine (2006)

Board Certifications

  • American Board of Internal Medicine / Critical Care Medicine (2007)
  • American Board of Internal Medicine / Pulmonary Disease (2006)

Research & Publications

Lab Website: The Sidhaye Lab
Core Facility: Microscopy/Confocal Imaging Core

Selected Publications

View all on Pubmed

Sussan TE, Gajghate S, Chatterjee S, Mandke P, McCormick S, Sudini K, Kumar S, Breysse PN, Diette GB, Sidhaye VK, Biswal S. "Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function." Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L27-36. doi: 10.1152/ajplung.00398.2014. Epub 2015 May 8.

Brune K, Frank J, Schwingshackl A, Finigan J, Sidhaye VK. "Pulmonary epithelial barrier function: some new players and mechanisms." Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15;308(8):L731-45. doi: 10.1152/ajplung.00309.2014. Epub 2015 Jan 30. Review.

Sebastian R, Chau E, Fillmore P, Matthews J, Price LA, Sidhaye V, Milner SM. "Epidermal aquaporin-3 is increased in the cutaneous burn wound." Burns. 2015 Jun;41(4):843-7. doi: 10.1016/j.burns.2014.10.033. Epub 2015 Jan 18.

Singer BD, Mock JR, Aggarwal NR, Garibaldi BT, Sidhaye VK, Florez MA, Chau E, Gibbs KW, Mandke P, Tripathi A, Yegnasubramanian S, King LS, D'Alessio FR. "Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation." Am J Respir Cell Mol Biol. 2015 May;52(5):641-52. doi: 10.1165/rcmb.2014-0327OC.

Mock JR, Garibaldi BT, Aggarwal NR, Jenkins J, Limjunyawong N, Singer BD, Chau E, Rabold R, Files DC, Sidhaye V, Mitzner W, Wagner EM, King LS, D'Alessio FR. "Foxp3+ regulatory T cells promote lung epithelial proliferation." Mucosal Immunol. 2014 Nov;7(6):1440-51. doi: 10.1038/mi.2014.33. Epub 2014 May 21.

Aggarwal NR, Tsushima K, Eto Y, Tripathi A, Mandke P, Mock JR, Garibaldi BT, Singer BD, Sidhaye VK, Horton MR, King LS, D'Alessio FR. "Immunological priming requires regulatory T cells and IL-10-producing macrophages to accelerate resolution from severe lung inflammation." J Immunol. 2014 May 1;192(9):4453-64. doi: 10.4049/jimmunol.1400146. Epub 2014 Mar 31.

Lai N, Lade J, Leggett K, Yun X, Baksh S, Chau E, Crow MT, Sidhaye V, Wang J, Shimoda LA. The Aquaporin 1 C-terminal Tail is Required for Migration and Growth of Pulmonary Arterial Myocytes. Am J Respir Cell Mol Biol. 2013 Dec 11. [Epub ahead of print] PMID: 24328827

Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. MK2 Mediates Apoptosis During Lung Vascular Permeability by Regulating Movement of Cleaved Caspase 3. Am J Respir Cell Mol Biol. 2013 Dec 4. [Epub ahead of print] PMID: 24304496

Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013 May;48(5):635-46. doi: 10.1165/rcmb.2012-0351OC. PMID: 23349051

Garibaldi BT, D'Alessio FR, Mock JR, Files DC, Chau E, Eto Y, Drummond MB, Aggarwal NR, Sidhaye V, King LS. Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment. Am J Respir Cell Mol Biol. 2013 Jan;48(1):35-43. doi: 10.1165/rcmb.2012-0198OC. Epub 2012 Sep 20. PMID: 23002097

D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol. 2012 Sep 1;189(5):2234-45. doi: 10.4049/jimmunol.1102606. Epub 2012 Jul 27. PMID: 22844117

Chau E, Galloway JF, Nelson A, Breysse PN, Wirtz D, Searson PC, Sidhaye VK. Effect of modifying quantum dot surface charge on airway epithelial cell uptake in vitro. Nanotoxicology. 2013 Sep;7(6):1143-51. doi: 10.3109/17435390.2012.711862. Epub 2012 Aug 20. PMID: 22783847

Sidhaye VK, Chau E, Srivastava V, Sirimalle S, Balabhadrapatruni C, Aggarwal NR, D'Alessio FR, Robinson DN, King LS. A novel role for aquaporin-5 in enhancing microtubule organization and stability. PLoS One. 2012;7(6):e38717. doi: 10.1371/journal.pone.0038717. Epub 2012 Jun 8. PMID: 22715407 [PubMed - in process]

Leggett K, Maylor J, Undem C, Lai N, Lu W, Schweitzer K, King LS, Myers AC, Sylvester JT, Sidhaye V, Shimoda LA. Hypoxia-induced migration in pulmonary arterial smooth muscle cells requires calcium-dependent upregulation of aquaporin 1. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15;303(4):L343-53. doi: 10.1152/ajplung.00130.2012. Epub 2012 Jun 8. PMID: 22683574

Academic Affiliations & Courses

Graduate Program Affiliation

Cell and Molecular Medicine

Environmental Health Sciences and Engineering

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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