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Sanjay Kumar Jain, M.B.B.S.

Director, Center for Infection and Inflammation Imaging Research
Professor of Pediatrics

Male

Languages: English, Hindi

Expertise

Infectious Diseases and International Health, Pediatric Infectious Disease

Research Interests

Tuberculosis; Pediatric tuberculosis; Imaging for infections and inflammatory diseases; CNS tuberculosis; Cellular and low-cost technologies to improve health care; Mycobacteria ...read more

“Sanjay Jain, M.D. Talks About His Novel TB Imaging Research”

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Maryland

410-614-3917

Outside of Maryland

410-464-6641

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+1-410-502-7683

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Locations

The Johns Hopkins Hospital

Appointment Phone: 410-614-3917

600 N. Wolfe Street
Cancer Research Building II
Baltimore, MD 21287 map

Phone: 410-502-8241 | Fax: 410-614-8173

Background

Dr. Sanjay Kumar Jain is a Professor of Pediatrics, Radiology and Radiological Science. He is also a Professor of International Health at the Bloomberg School of Public Health. His areas of clinical expertise include infectious diseases and international health and pediatric infectious disease.

Dr. Jain serves as the director of the Center for Infection and Inflammation Imaging Research.

Born in Halifax, Canada, Dr. Jain grew up in India. He received his medical degree in 1999 from All India Institute of Medical Sciences in New Delhi, where he was a house officer in neuroradiology. He trained in pediatrics at Penn State Children’s Hospital, Milton S. Hershey Medical Center, and the Tufts University School of Medicine. He was a clinical fellow in pediatric infectious diseases at Johns Hopkins before joining its faculty in 2005. Dr. Jain was named an associate professor of pediatrics in the Division of Pediatric Infectious Diseases in 2011.

The focus of Dr. Jain’s research is to find new and better ways to combat tuberculosis (TB). To this end, his research focuses on the development and use of imaging technologies to study TB pathogenesis and as tools for monitoring disease. He also studies the pathogenesis of CNS TB and utilization of new diagnostics for childhood TB. In the Center for TB Research at Johns Hopkins, he and his research colleagues received a 2007 $1 million Bill & Melinda Gates Foundation award to design a system that visually tracks the behavior of M. tuberculosis in the body with the goal of developing faster, cheaper drug therapies against a disease that affects billions around the world.

Dr. Jain is an organizing member of the TB Drug Accelerator Meeting for the Bill & Melinda Gates Foundation. He has been recognized with several awards, including $2.2 million in funding through a Transformative Research Award from the National Institutes of Health and a NIH Director’s New Innovator Award in 2009.

Titles

Director, Center for Infection and Inflammation Imaging Research
Professor of Pediatrics
Professor of Radiology and Radiological Science

Departments / Divisions

Centers & Institutes

Global Health Faculty, Center for
Infection and Inflammation Imaging Research, Center for
Johns Hopkins Children's Center
Sidney Kimmel Comprehensive Cancer Center
Infection and Inflammation Imaging Research at the Division of Infectious Diseases (Ci3R), Center for

Education

Degrees

MBBS, All India Institute of Medical Sciences (1999)

Residencies

Penn State Health Milton S Hershey Medical Center / Pediatrics (2000)
Tufts-New England Medical Center Hospitals / Pediatrics (2002)

Fellowships

Johns Hopkins University School of Medicine / Pediatric Infectious Diseases (2005)

Research & Publications

Research Summary

Dr. Jain’s primary research interests include the development of imaging technology for real-time evaluation of M. tuberculosis infection and pathogenesis of central nervous system (CNS) tuberculosis. He has developed both in vitro and in vivo murine models to study CNS invasion by M. tuberculosis.

As part of a Gates Foundation-funded project, Dr. Jain is developing imaging technologies to evaluate M. tuberculosis infections in real-time. These include CT and PET imaging to evaluate the anatomic and inflammatory state of lungs of animals experimentally infected with M. tuberculosis. Using novel radio-nucleotide imaging technology, Dr. Jain is also developing technologies to image live mycobacteria using SPECT imaging. He is also leading a study to evaluate a novel TB test for the diagnosis of active TB in young HIV-infected children in India.

Core Facility: Infection and Inflammation Imaging Research at the Division of Infectious Diseases (Ci3R), Center for

Selected Publications

View all on Pubmed

Be NA, Bishai WR, Jain SK. "Role of Mycobacterium tuberculosis pknD in the Pathogenesis of Central Nervous System Tuberculosis." BMC Microbiol. 2012, 12:7. Highly accessed.

Harper J, Skerry C, Davis SL, Tasneen R, Weir W, Kramnik I, Bishai WR, Pomper MG, Nuermberger EL, Jain SK. "Mouse model of necrotic TB granulomas develops hypoxic lesions." J Infect Dis. 2012 Feb;205(4):595-602. Epub 2011 Dec 23.

Be NA, Klinkenberg LG, Bishai WR, Karakousis PK, Jain SK. "Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge." Tuberculosis (Edinb). 2011 Sep;91(5):386-9.

Vidal C, Beggs D, Younes L, Jain SK, Jedynak B. "Incorporating user input in template-based segmentation." Proceedings of the IEEE International Symposium on Biomedical Images 2011.

Dutta NK, Mehra S, Didier PJ, Roy CJ, Doyle LA, Alvarez X, Ratterree M, Be NA, Lamichhane G, Jain SK, Lacey MR, Lackner AA, Kaushal D. "Genetic requirements for the survival of tubercle bacilli in primates." J Infect Dis. 2010 Jun 1;201(11):1743-52.

Vidal C, Hewitt J, Davis S, Younes L, Jain S, Jedynak B. Template Registration with missing parts: Application to the Segmentation of Tuberculosis infected lungs. Proceedings of the IEEE International Symposium on Biomedical Images (in press).

Be N, Kim KS, Bishai WR, Jain SK. Pathogenesis of Central Nervous System Tuberculosis. Curr Mol Med. 2009 Mar;9(2):94-9.

Converse PJ, Karakousis PC, Klinkenberg KC, Kesavan AK, Ly LH, Allen SS, Grosset JH, Jain SK, Lamichhane G, Manabe YC, McMurray DN, Nuermberger EL, Bishai WR. The role of the dosR/dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models. Infect Immun. 2009 Mar;77(3):1230-7.

Agwu AL, Lee CK, Jain SK, Murray KL, Topolski J, Miller, RE, Townsend T, Lehmann CU. A World Wide Web-based antimicrobial stewardship program improves efficiency, communication, and user satisfaction and reduces cost in a tertiary care pediatric medical center. Clin Infect Dis. 2008 Sep 15;47(6):747-53.

Be N, Lamichhane G, Grosset J, Tyagi S, Cheng Q, Kim KS, Bishai WR, Jain SK. Cover Page picture. J Infect Dis. 2008 Nov 15;198(10).

Be N, Lamichhane G, Grosset J, Tyagi S, Cheng Q, Kim KS, Bishai WR, Jain SK. Murine model to study Invasion and Survival of Mycobacterium tuberculosis in the Central Nervous System. J Infect Dis. 2008 Nov 15;198(10):1520-8.

Jain SK, Lamichhane G, Nimmagadda S, Pomper M, Bishai WR. Antibiotic Treatment of Tuberculosis: Old Problems, New Solutions. Microbe 2008 Jun; 3(6): 285-92.

Jain SK, Hernandez-Abanto S, Cheng Q, Singh P, Ly LH, Klinkenberg G, Morrison NE, Converse PJ, Nuermberger E, Grosset J, McMurray DN, Karakousis PC, Lamichhane G, Bishai WR. Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs compared with mice. J Infect Dis. 2007 Jun 1;195(11):1634-42.

Hernandez-Abanto S, Woolwine SC, Jain SK, Bishai WR. Tetracycline-inducible gene expression in mycobacteria within an animal host using Streptomyces-derived tetO and tetR regulatory elements. Arch Microbiol. 2006 Dec;186(6):459-64.

Jain SK, Bishai WR. Adherence, treatment success, and resistance. Infect Dis Clin Pract. 2006 July 14(4) Supplement 4:S15-S18.

Jain SK, Paul-Satyaseela M, Lamichhane G, Kim KS, Bishai WR. Mycobacterium tuberculosis Invasion and Traversal across an In Vitro Human Blood-Brain Barrier as a Pathogenic Mechanism for Central Nervous System Tuberculosis. J Infect Dis. 2006 May 1;193(9):1287-95.

Bhally HS, Jain S, Shields C, Halsey N, Cristofalo E, Merz WG. Infection in a neonate caused by Pichia fabianii: importance of molecular identification. Med Mycol. 2006 Mar;44(2):185-7.

Jain SK, Tunkel DE, Bishai WR. Management of Acute Rhinosinusitis, Bronchitis Syndromes, and Acute Otitis Media. Adv Stud Med. 2005; 5(7):344-350.

Jain SK, Kwon P, Moss WJ. Management and outcomes of intracranial tuberculomas developing during antituberculous therapy: case report and review. Clin Pediatr (Phila). 2005 Jun;44(5):443-50.

Jain SK, Persaud D, Perl TM, Pass MA, Murphy KM, Pisciotta JM, Scholl PF, Casella JF, Sullivan DJ. Nosocomial Malaria and Saline Flush. Emerg Infect Dis. 2005 July;11(7):1097-99.

Jain SK, Gupta A, Glanz B, Dick J, Siberry GK. Antimicrobial-resistant Shigella sonnei: Limited antimicrobial treatment options for children and challenges of interpreting in vitro azithromycin susceptibility. Pediatr Infect Dis J. 2005 Jun;24(6):494-497.

Jain SK. Index of suspicion. Case 3. Diagnosis: Jaundice. Pediatr Rev. 2001 Aug;22(8):271-6.

Jain SK, Deepak KK. Cost Effective Computerized Analysis of Biological Signals. Indian J Physiol Pharmacol 1995; 39(4): 389-394.

PubMed

Academic Affiliations & Courses

Graduate Program Affiliation

Pathobiology

Activities & Honors

Honors

Named Marylands Innovator of the Year, The Daily Record, 2008
Named amongst Americas Best and the Brightest in the Arts, Sciences and Social change, The Genius Issue & Innovators, Esquire Magazine, 2007
Program Choice Award, IDSA, 2005
Education scholarship, Bill and Melinda Gates Foundation, 2005
Pediatric Infectious Diseases Society Award, IDSA, 2005
Special citation for fellow-in-training, IDSA, 2005
Transformative Research Award, National Institutes of Health, 2014
NIH Director’s New Innovator Award, National Institutes of Health, 2009
Fellows Travel Award, Infectious Diseases Society of America, 2005
Young Investigator’s Travel Award, American Pediatric Society & Society for Pediatric Research, 2005
Clinician Scientist Award, Johns Hopkins University, 2005 - 2007

Professional Activities

Organizing Member, TB Drug Accelerator Meeting, Bill & Melinda Gates Foundation, Seattle, WA, 2009

Videos & Media

Lectures and Presentations

“The Role of Imaging in Infectious Diseases, RAD-AID Conference on International Radiology for Developing Countries”
Conference, Baltimore, MD (10/01/2011)
Johns Hopkins University
“Diagnosis of Pediatric TB: Is There a Need for Newer Technologies?”
Workshop on TB and HIV Diagnostics in Adult and Pediatric Populations, Silver Spring, MD (06/01/2011)
NIH
“Non-invasive Imaging as a Tool for Pre-Clinical Studies In Animal Models Of Tuberculosis, Current and Future Role of Imaging in the Evaluation of Infectious Diseases”
Presentation, Rockville, MD (05/01/2011)
CIDI, NIH
Non-invasive Imaging in Animal Models, INDO-US NIAID Drug Discovery Forum: Exploring Opportunities for Research Collaboration”
Joint Conference, New Delhi, India (04/01/2011)
DBT DHR ICMR and NIAID/NIH
“Tuberculosis Update”
Conference, 39th Annual Pediatric Trends, Baltimore, MD (04/01/2011)
Johns Hopkins University
“M.tb. PknD Interaction With Laminin: A Trigger for Host-Cell Invasion and Bacterial Dormancy in the CNS”
Lecture, Delhi, India
Translational Health Science and Technology Institute
“TB in South East Asia”
Lecture, APAMSA National Conference, Baltimore, MD (10/01/2010)
Johns Hopkins University
“What You Need to Know about TB?”
Grand Rounds, Baltimore, MD (05/01/2010)
Sinai Hospital of Baltimore
“Tuberculosis Update”
Conference, 38th Annual Pediatric Trends, Baltimore, MD (04/01/2010)
Johns Hopkins University
“Monitoring TB Disease in Live Animals: The 21st Century, Satellite Symposium on TB Animal Models”
Lecture, Union World Meeting Symposium, Cancun, Mexico (12/01/2009)
“Non-invasive Imaging to Assess Disease in a Mouse Model Of Tuberculosis (TB) at the Fall Imaging Symposium”
Lecture, Baltimore, MD (11/01/2009)
Johns Hopkins University
“Pneumonia at the World PNA Day”
Lecture, Baltimore, MD (11/01/2009)
Johns Hopkins University
“Molecular Imaging for Infection and Inflammation at the Oncology Center”
Lecture, Baltimore, MD (09/01/2009)
Johns Hopkins University Grand Rounds
“Monitoring Tuberculosis Treatment with [18F]FDG-PET”
Lecture, Center for Tuberculosis Research Annual Scientific Meeting, Baltimore, MD (06/01/2009)
Center for Tuberculosis Research
“Real-time In Vivo Imaging of Mycobacterium Tuberculosis Infection at the TB Drug Accelerator Meeting”
Lecture, Seattle, WA (03/01/2009)
Gates Foundation

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