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Paul M Hassoun, M.D.

Photo of Dr. Paul M Hassoun, M.D.
  • Director, Pulmonary Hypertension Program
  • Professor of Medicine

Languages: English, Arabic, French


Critical Care Medicine, Pulmonary Disease and Critical Care Medicine, Pulmonary Hypertension

Research Interests

Acute lung injury; Regulation and role of xanthine oxidase in lung injury; Molecular determinants of pulmonary hypertension; Pulmonary hypertension/Scleroderma-associated pulmonary hypertension more

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The Johns Hopkins Hospital

Appointment Phone: 410-550-5864
1830 E. Monument Street
1830 Building 5th Floor Pulmonary
Baltimore, MD 21287 map
Phone: 410-955-3467 | Fax: 410-614-7451

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-550-0545 | Fax: 410-550-2612

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-3467
601 N. Caroline St.
Baltimore, MD 21287 map
Fax: 410-614-7451


Dr. Paul M. Hassoun is a professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include pulmonary disease and critical care medicine. 

Dr. Hassoun serves as the director of the Pulmonary Hypertension Program.

He earned his M.D. from Faculte de Medecine Lariborsiere. He completed his residency at Brigham and Women's Hospital and performed a fellowship at Massachusetts General Hospital and at New England Medical Center Hospitals.

Dr. Hassoun's research interests include acute lung injury, regulation and role of xanthine oxidase in lung injury, and molecular determinants of pulmonary hypertension.

He was recognized by the Department of Medicine with a Levine Excellence in Mentoring Award in 2008. He is a member of numerous professional organizations, including the American Heart Association, the American Thoracic Society and the European Respiratory Society. more


  • Director, Pulmonary Hypertension Program
  • Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD, Faculte' de Medecine Lariborsiere - (1981)


  • Brigham and Women's Hospital (1984)


  • Massachusetts General Hospital (1987)
  • Tufts-New England Medical Center Hospitals (1988)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (1984)
  • American Board of Internal Medicine / Pulmonary Disease (1986)

Research & Publications

Research Summary

Dr. Hassoun is directing a research program investigating the cause and treatment of pulmonary arterial hypertension in scleroderma.

Selected Publications

View all on Pubmed

Al-Naamani N, Palevsky HI, Lederer DJ, Horn EM, Mathai SC, Roberts KE, Tracy RP, Hassoun PM, Girgis RE, Shimbo D, Post WS, Kawut SM; ASA-STAT Study Group. "Prognostic significance of biomarkers in pulmonary arterial hypertension." Ann Am Thorac Soc. 2015 Oct 26. [Epub ahead of print]

Mathai SC, Suber T, Khair RM, Kolb TM, Damico RL, Hassoun PM. "Health-related quality of life and survival in pulmonary arterial hypertension." Ann Am Thorac Soc. 2015 Oct 22. [Epub ahead of print]

Gao L, Emond MJ, Louie T, Cheadle C, Berger AE, Rafaels N, Vergara C, Kim Y, Taub MA, Ruczinski I, Mathai SC, Rich SS, Nickerson DA, Hummers LK, Bamshad MJ, Hassoun PM, Mathias RA; National Heart, Lung, and Blood Institute (NHLBI) GO Exome Sequencing Project, Barnes KC. "Whole-exome sequencing identifies rare variants in ATP8B4 as a risk factor for systemic sclerosis." Arthritis Rheumatol. 2015 Oct 16. doi: 10.1002/art.39449. [Epub ahead of print]

Corona-Villalobos CP, Kamel IR, Rastegar N, Damico R, Kolb TM, Boyce DM, Sager AE, Skrok J, Shehata ML, Vogel-Claussen J, Bluemke DA, Girgis RE, Mathai SC, Hassoun PM, Zimmerman SL. "Bidimensional measurements of right ventricular function for prediction of survival in patients with pulmonary hypertension: comparison of reproducibility and time of analysis with volumetric cardiac magnetic resonance imaging analysis." Pulm Circ. 2015 Sep;5(3):527-37. doi: 10.1086/682229.

Fallica J, Varela L, Johnston L, Kim B, Serebreni L, Wang L, Damarla M, Kolb TM, Hassoun PM, Damico R. "Macrophage migration inhibitory factor (MIF) is a novel inhibitor of ASK1-p38-XOR-dependent cigarette smoke-induced apoptosis." Am J Respir Cell Mol Biol. 2015 Sep 21. [Epub ahead of print]

Damarla M, Parniani AR, Johnston L, Maredia H, Serebreni L, Hamdan O, Sidhaye VK, Shimoda LA, Myers AC, Crow MT, Schmidt EP, Machamer CE, Gaestel M, Rane MJ, Kolb TM, Kim BS, Damico RL, Hassoun PM. MK2 Mediates Apoptosis During Lung Vascular Permeability by Regulating Movement of Cleaved Caspase 3. Am J Respir Cell Mol Biol. 2013 Dec 4. [Epub ahead of print] PMID: 24304496

Nathan SD, Hassoun PM. Pulmonary Hypertension due to Lung Disease and/or Hypoxia. Clin Chest Med. 2013 Dec;34(4):695-705. doi: 10.1016/j.ccm.2013.08.004. Epub 2013 Oct 17. PMID: 24267299 [PubMed - in process]

Chaisson NF, Hassoun PM. Systemic sclerosis-associated pulmonary arterial hypertension. Chest. 2013 Oct;144(4):1346-56. doi: 10.1378/chest.12-2396. PMID: 24081346 [PubMed - in process]

Tedford RJ, Mudd JO, Girgis RE, Mathai SC, Zaiman AL, Housten-Harris T, Boyce D, Kelemen BW, Bacher AC, Shah AA, Hummers LK, Wigley FM, Russell SD, Saggar R, Saggar R, Maughan WL, Hassoun PM, Kass DA. Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension. Circ Heart Fail. 2013 Sep 1;6(5):953-63. PMID: 23797369

Hassoun PM, Shafiq M. Tackling the challenges of systemic sclerosis-associated pulmonary hypertension: one step forward. Arthritis Rheum. 2013 Sep;65(9):2240-2. doi: 10.1002/art.38031. No abstract available. PMID: 23740649

Hassoun PM, Nikkho S, Rosenzweig EB, Moreschi G, Lawrence J, Teeter J, Meier C, Ghofrani AH, Minai O, Rinaldi P, Michelakis E, Oudiz RJ. Updating clinical endpoint definitions. Pulm Circ. 2013 Jan;3(1):206-16. doi: 10.4103/2045-8932.109920. PMID: 23662199

Hoeper MM, Barst RJ, Bourge RC, Feldman J, Frost AE, Galié N, Gómez-Sánchez MA, Grimminger F, Grunig E, Hassoun PM, Morrell NW, Peacock AJ, Satoh T, Simonneau G, Tapson VF, Torres F, Lawrence D, Quinn DA, Ghofrani HA. Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study. Circulation. 2013 Mar 12;127(10):1128-38. doi: 10.1161/CIRCULATIONAHA.112.000765. Epub 2013 Feb 12. PMID: 23403476

Mathai SC, Hassoun PM. Drs. Mathai and Hassoun reply. J Rheumatol. 2013 Jan;40(1):91. No abstract available. PMID: 23401876

Kim BS, Serebreni L, Hamdan O, Wang L, Parniani A, Sussan T, Scott Stephens R, Boyer L, Damarla M, Hassoun PM, Damico R. Xanthine oxidoreductase is a critical mediator of cigarette smoke-induced endothelial cell DNA damage and apoptosis. Free Radic Biol Med. 2013 Jul;60:336-46. doi: 10.1016/j.freeradbiomed.2013.01.023. Epub 2013 Feb 4. PMID: 23380026

Shehata ML, Harouni AA, Skrok J, Basha TA, Boyce D, Lechtzin N, Mathai SC, Girgis R, Osman NF, Lima JA, Bluemke DA, Hassoun PM, Vogel-Claussen J. Regional and global biventricular function in pulmonary arterial hypertension: a cardiac MR imaging study. Radiology. 2013 Jan;266(1):114-22. doi: 10.1148/radiol.12111599. Epub 2012 Nov 14. PMID: 23151825

Activities & Honors


  • The David M Levine Excellence in Mentoring Award, Johns Hopkins University Department of Medicine, 2008
  • Chair, American Thoracic Society, 2008
  • Excellence in Teaching Award, Tufts University School of Medicine, 2002
  • Excellence in Teaching Award, Tufts University School of Medicine, 2001
  • Oliver Smith Award, New England Medical Center, 2001
  • Clinical Investigator Award, 1988 - 1990
  • Winthrop Breon/ACCP Scholar Award, American Lung Association/American Thoracic Society, 1986


  • American Heart Association
  • American Thoracic Society
  • European Respiratory Society
  • Fellow, American College of Chest Physicians
  • Maryland Thoracic Society
  • Massachusetts Thoracic Society
  • Physicians for Human Rights

Professional Activities

  • Chair, American Thoracic Society, 2008

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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