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Paul Alan Nyquist, M.D., M.P.H.
Male
Expertise: Neurological Critical Care, Neurology, Stroke
Research Interests: Acute Brain Injury; White Matter Disease; Subarachnoid Hemorrhage; Stroke Genetics; Intracranial Hemorrhage
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600 N. Wolfe Street
Meyer Building 8-138
Baltimore, MD 21287
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Phone: 410-955-2611
Fax: 410-614-7903
At Johns Hopkins, Dr. Paul Nyquist has two roles as an attending physician in the neurocritical care unit (NCCU) and as a member of the cerebrovascular team. His research goal is to bridge the gap between clinical trials and bench top innovations. He has embraced a research strategy characterized by two features. The first is an ongoing interest in any translational research projects that incorporate well founded biological models into patient care in brain injury. He has a theoretical focus which emphasizes the role of inflammation in cerebrovascular disease with particular attention to the effects of inflammation on endothelial activation. His goal is to develop acute interventions that will improve outcomes in patients with acute brain injury of any type.
Dr. Paul Nyquist received his medical degree and masters of public health degree from the George Washington University. After medical school, Dr. Nyquist completed his internal medicine internship at the National Naval Medical Center in Bethesda, Maryland. Upon completion, he was trained as a Navy Second Class Deep Sea Diver, radiation health specialist and an Undersea Medical Officer. Dr. Nyquist was part of the United States Naval world wide dive watch and rendered on call medical advice for diving and decompression related injuries for the United States Navy.
His clinical neurological training includes a neurology residency at the Mayo Clinic in Rochester, Minnesota as well as a senior staff clinical fellowship at the National Institutes of Health in the National Institutes of Neurological Diseases and Stroke in Bethesda, Maryland. He was a critical care medicine fellow in the ACGME accredited National Institutes of Health Critical Care Medicine program for 16 months. Dr. Nyquist then served as director of the stroke program at Inova Fairfax Hospital, assistant professor of Neurology at Virginia Commonwealth University Medical School, and clinical assistant professor of Psychiatry at Georgetown University Medical School. He completed his Neurocritical care fellowship training at Johns Hopkins and is now an Associate Professor of Neurology, Neurosurgery and Anesthesiology/Critical Care at the Johns Hopkins University School of Medicine.
Dr. Paul Nyquist has an ongoing interest in any translational research project that incorporates well-founded biologic models into patient care in brain injury. He has been involved in a number of clinical trials that have been at the forefront of new technologic innovations in brain injury and has extensive experience in clinical trials in both military and civilian settings. These trials often have involved protocols with high clinical impact on those enrolled.
Dr. Nyquist also has a theoretical focus that emphasizes the role of inflammation in cerebrovascular disease, with particular attention to the effects of inflammation on endothelial activation. He is interested in how inflammation and endothelial activation affect the neurovascular unit. To that end, he is investigating the role of genetic variation on the proclivity of the endothelium to become transformed into a procoagulant state in carotid atherosclerosis.
Using extensive clinical testing for commonly detected risk factors in cerebral vascular disease, Dr. Nyquist is exploring how cerebrovascular small-vessel disease in patients who are predisposed to atherosclerosis may be influenced by inflammation and genetic history. He is also investigating how biomarkers may be used to detect damage in each compartment of the neurovascular unit in the settings of vasospasm and cerebral salt wasting in patients with subarachnoid hemorrhage.
Dr. Nyquist believes that an interrelationship exists between small-vessel disease of the brain and small-vessel disease of the heart and that a number of potential genes may predispose to both. In a study that he conducted in a group of patients who had asymptomatic small-vessel disease of the heart, he found a cross-correlation with silent small-vessel strokes in the brain. His goal is to identify the genes that are associated with cerebral vascular disease in the hopes of developing new treatments for this condition that afflicts millions worldwide.
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