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Enid Rose Neptune, M.D.

Photo of Dr. Enid Rose Neptune, M.D.
  • Associate Professor of Medicine

Languages: English, Spanish


Chronic Obstructive Pulmonary Disease (COPD), Critical Care Medicine, Marfan Syndrome, Pulmonary Disease and Critical Care Medicine, Pulmonary Medicine more

Research Interests

Therapeutic strategies in Marfan syndrome; Mechanisms and prevention of progression of COPD; Hepatocyte growth factor signaling in airspace homeostasis more

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Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-3467

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-3467
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map


Dr. Enid Neptune is an associate professor of medicine at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include chronic obstructive pulmonary disease, critical care medicine and Marfan syndrome. 

Dr. Neptune earned her M.D. from Harvard Medical School. She completed her residency and performed a fellowship in pulmonary and critical care at the University of California, San Francisco. She also performed a fellowship in genetics at Johns Hopkins. 

Her research interests include therapeutic strategies in Marfan syndrome; mechanisms and prevention of progression of COPD; and hepatocyte growth factor signaling in airspace homeostasis.

Dr. Neptune serves on the Compliance Compensation Subcommittee for the Department of Medicine. more


  • Associate Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD, Harvard Medical School (1988)


  • University of California San Francisco School of Medicine / Internal Medicine (1991)


  • University of California San Francisco School of Medicine / Pulmonary and Critical Care Medicine (1998)
  • Johns Hopkins University School of Medicine / Genetics (2001)

Board Certifications

  • American Board of Internal Medicine / Critical Care Medicine (1999)

Research & Publications

Selected Publications

View all on Pubmed

Hansel NN, Paré PD, Rafaels N, Sin DD, Sandford A, Daley D, Vergara C, Huang L, Elliott WM, Pascoe CD, Arsenault BA, Postma DS, Boezen HM, Bossé Y, van den Berge M, Hiemstra PS, Cho MH, Litonjua AA, Sparrow D, Ober C, Wise RA, Connett J, Neptune ER, Beaty TH, Ruczinski I, Mathias RA, Barnes KC; Lung Health Study. "Genome-wide association study identification of novel loci associated with airway responsiveness in chronic obstructive pulmonary disease." Am J Respir Cell Mol Biol. 2015 Aug;53(2):226-34. doi: 10.1165/rcmb.2014-0198OC.

Lambert AA, Kirk GD, Astemborski J, Neptune ER, Mehta SH, Wise RA, Drummond MB. "A cross sectional analysis of the role of the antimicrobial peptide cathelicidin in lung function impairment within the ALIVE cohort." PLoS One. 2014 Apr 17;9(4):e95099. doi: 10.1371/journal.pone.0095099.

Poonyagariyagorn HK, Metzger S, Dikeman D, Mercado AL, Malinina A, Calvi C, McGrath-Morrow S, Neptune ER. "Superoxide dismutase 3 dysregulation in a murine model of neonatal lung injury." Am J Respir Cell Mol Biol. 2014 Sep;51(3):380-90. doi: 10.1165/rcmb.2013-0043OC.

Calvi C, Podowski M, Lopez-Mercado A, Metzger S, Misono K, Malinina A, Dikeman D, Poonyagariyon H, Ynalvez L, Derakhshandeh R, Le A, Merchant M, Schwall R, Neptune ER. "Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung." PLoS Genet. 2013;9(2):e1003228. doi: 10.1371/journal.pgen.1003228. Epub 2013 Feb 14.

Hansel NN, Ruczinski I, Rafaels N, Sin DD, Daley D, Malinina A, Huang L, Sandford A, Murray T, Kim Y, Vergara C, Heckbert SR, Psaty BM, Li G, Elliott WM, Aminuddin F, Dupuis J, O'Connor GT, Doheny K, Scott AF, Boezen HM, Postma DS, Smolonska J, Zanen P, Mohamed Hoesein FA, de Koning HJ, Crystal RG, Tanaka T, Ferrucci L, Silverman E, Wan E, Vestbo J, Lomas DA, Connett J, Wise RA, Neptune ER, Mathias RA, Paré PD, Beaty TH, Barnes KC. "Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD." Hum Genet. 2013 Jan;132(1):79-90. doi: 10.1007/s00439-012-1219-6. Epub 2012 Sep 18.

Calvi CL, Podowski M, D'Alessio FR, Metzger SL, Misono K, Poonyagariyagorn H, Lopez-Mercado A, Ku T, Lauer T, Cheadle C, Talbot CC Jr, Jie C, McGrath-Morrow S, King LS, Walston J, Neptune ER. Critical transition in tissue homeostasis accompanies murine lung senescence. PLoS One. 2011;6(6):e20712. doi: 10.1371/journal.pone.0020712. Epub 2011 Jun 21. PMID: 21713037

Activities & Honors

Professional Activities

  • Compliance Compensation Subcommittee, Johns Hopkins Department of Medicine, Baltimore, MD

Videos & Media

Recent News Articles and Media Coverage

Fighting To Breathe: Living With COPD,” NPR, June 12, 2013

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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