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School of Medicine
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Thien Tuong Nguyen, M.D.
Languages: English, Vietnamese
Expertise: Neurology, Neuromuscular Disease
Dr. Thien Nguyen focuses on the diagnosis and treatment of neuromuscular and demyelinating diseases. The collective experience from multiple sclerosis, inflammatory demyelinating neuropathies, and heritable demyelinating diseases suggests that axonal degeneration accounts for a significant portion of the neurologic deficits in patients affected with these disorders.
Dr. Nguyen’s laboratory focuses on delineating the molecular mechanisms governing axonal degeneration in demyelinating and dysmyelinating disorders, so that neuroprotective strategies can be discovered. One promising neuroprotective agents is myelin-associated-glycoprotein (MAG), which Dr. Nguyen’s lab has shown to robustly prevent axonal degeneration in a variety of neural injury paradigms. Such promising neuroprotective agents identified in the laboratory can then be tested in future clinical trials in a ''bench-to-bedside'' manner to prevent axonal loss.
Dr. Thien Nguyen received his M.D. and Ph.D. from the University of Washington School of Medicine in Seattle. He then completed an internship in medicine at the University of Washington School of Medicine and residency in neurology at The Johns Hopkins Hospital in Baltimore. He went on to complete a fellowship in neuromuscular and neurophysiology at The Johns Hopkins Hospital in Baltimore.
Departments / Divisions
- Medicine at Suburban Hospital
Centers & Institutes
- MD, University Of Washington School Of Medicine (1999)
- Johns Hopkins University School of Medicine / Neurology (2003)
- Johns Hopkins University School of Medicine / Neurology (2004)
- American Board of Psychiatry & Neurology / Neurology (2005)
Research & Publications
1. Nguyen, T., Chin, W.C., & Verdugo, P. (1998). Role of Ca2+/K+ ion exchange in intracellular storage and release of Ca2+. Nature 395, 908-912.
1. Nguyen, T., Chin, W.C., O''Brien, J. A., & Verdugo, P., & Berger, A. (2001). Intracellular pathways regulating ciliary beating of rat brain ependymal cells. J. Phys. (Lond.) 531 (1), 131-140 (cover article).
1. Chin, W.C., Quesada, I., Nguyen, T., & Verdugo, P. (2002). Oscillations of pH inside the
secretory granule control the gain of Ca2+ release for signal transduction in goblet cell exocytosis. Novartis Found Symp 248, 132-141.
1. Nguyen, T. (2002). Case 12: A 56-year old man with acute quadriparesis. Medscape.
Chapters in Books:
1. Nguyen T., Peter Kaplan. Imitators of Epilepsy. Clinical Presentation of Epilepsy, 1st ed. Ed. Le Quang Cuong. Nha Xuat Ban Y Hoc, 2005 (in Press Vietnamese)
2. Griffin, T, Hoke, A., Nguyen, T. Axonal Degeneration and Rescue. Textbook of Neural Repair and Rehabilitation, 2nd ed. Ed. Selzer, Clarke, Cohen, Duncan, and Gage. Cambridge University Press, 2005. (in Press)
Abstracts and Presentations:
1. Nguyen, T., Escobar, A., Vergara, J. & Verdugo, P. (1994). Ca2+ sub-compartmentalization in ciliated cells. NASA Annual Meeting.
1. Nguyen, T., & Verdugo, P. (1995). Detection of ciliary beat frequency and metachronal wavelength by two dimensional FFT analysis. Biophys. J. 68, A289.
2. Nguyen, T., & Verdugo, P. (1995). Sub-cellular compartmentalization of Ca2+ in respiratory ciliated cells. Amer. J. of Respir. and Critical Care Med. 151 (4), A652
3. Nguyen, T. (1996). Dynamics of cytosolic and compartmentalized Ca2+ during signal transduction. Ph.D. Thesis. University of Washington, Seattle, USA.
3. Nguyen, T., Arroyo, E. J., Scherer, S. S., & Griffin, J. W. (2004). β, β- Iminodipropionitrile-induced paranodal demyelination disrupts the molecular Organization of nodes. Annual Meeting of AAN S36, 005 (Platform presentation)
3. Nguyen, T., Sheikh, K, Garcia, M., Cleveland, D., Carteret, A., & Griffin, J. (2005) Neurofilament Phosphorylation is not Required for the Maintenance of Axonal Survival by MAG. PNS society meeting, S003 (Platform presentation).
Activities & Honors
- National Multiple Sclerosis Society Grant, 2005
- Peripheral Nerve Society Fellowship Award, 2005
- Nancy Davis Foundation Grant, 2005
- Speaker at Maryland Neurological Society, 2001
- Student representative on medical school curriculum committee, 1995 - 1999
- Molecular Biophysics Fellowship, 1992 - 1995