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Clifford Raabe Weiss, M.D.
Medical Director, The Johns Hopkins Center for Bioengineering, Innovation and Design (CBID)
Associate Professor of Radiology and Radiological Science
Expertise: Angioplasty, Arterial Occlusive Disease, Arteriovenous Fistulas (AVF), Arteriovenous Malformations (AVM), Chronic Total Occlusions, Claudication, Congenital Pulmonary Malformations, Deep Vein Thrombosis (DVT), Diabetic Foot Ulcers, Diagnostic Radiology, Hereditary Hemorrhagic Telangiectasia (HHT), IVC Filter Placement, IVC Filter Retrievals, Kidney Cancer, Liver Cancer, Lower Extremity Angioplasty, Lower Extremity Stenting, Peripheral Arterial Disease (PAD), Peripheral Vascular Disease, Radiofrequency Ablation for Bone Lesions, Radiofrequency Ablation for the Kidney, Radiofrequency Ablation for the Liver, Radiofrequency Ablation for the Lung, Radiology, Renal Artery Disease, Renal Vascular Disease, Uterine Fibroids, Varicocele, Vascular and Interventional Radiology, Vascular Malformations, Venous Disease, Venous Occlusive Disease, Venous Thromboembolism, Visceral Angioplasty, Visceral Stenting ...read more
Research Interests: Interventional treatment of obesity (bariatric embolization); Device development; Development of interventional MRI techniques; The diagnosis and treatment of vascular malformations, including pulmonary AVM's and Hereditary Hemorrhagic Telangiectasia (HHT) ...read more
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Dr. Clifford Weiss is an Associate Professor of Radiology and Radiological Science. He also holds appointments in Surgery and Biomedical Engineering. Additionally, he serves as Medical Director of the Johns Hopkins Center for Bioengineering Innovation and Design (CBID).
Dr. Weiss’ clinical focus lies in vascular and interventional radiology. He specializes in the diagnosis and treatment of vascular malformations, including pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia; varicoceles; MRI-guided interventions, especially for the treatment of vascular malformations; advanced venous interventions; and advanced biliary interventions.
Dr. Weiss' research focuses primarily on the preclinical and clinical development of Bariatric Embolization, a new endovscular procedure designed to help fight obesity.
Dr. Weiss received his B.A. from Dartmouth College in 1995, his M.D. from the Johns Hopkins University School of Medicine in 2001. He completed an internship in internal medicine on the Osler Service in 2002, his residency in Diagnostic Radiology in 2007, and a Fellowship in Vascular and Interventional radiology in 2008, all at The Johns Hopkins Hospital.
He is certified by the American Board of Radiology in diagnostic radiology and in vascular and interventional radiology, and he is a Fellow of the Society of Interventional Radiology.
- Medical Director, The Johns Hopkins Center for Bioengineering, Innovation and Design (CBID)
- Director, Interventional Radiology Research
- Director of the Johns Hopkins Vascular Anomalies Center
- Director of the Johns Hopkins HHT Center of Excellence
- Associate Professor of Radiology and Radiological Science
- Associate Professor of Biomedical Engineering
Departments / Divisions
- MD, Johns Hopkins University School of Medicine (2001)
- Johns Hopkins University School of Medicine / Radiology (2007)
- Johns Hopkins University School of Medicine / Vascular and Interventional Radiology (2008)
Research & Publications
The focus of Dr. Weiss' research is the development of Bariatric Emboliztion, a new, minimally invasive endovascular approach for the treatment of Obesity. Dr. Weiss is the PI or co-PI on a number of pre clinical grants relatiing to this work, and is the co-PI of the BEAT Obesity trial.
Dr. Weiss' research has also focused on research related to his clinical practice including the development and implementation Interventional MRI techniques, improving the diagnosis, treatment and outcomes assessment for patients with vascular malformations (indluding HHT and pulmonary AVM), and the interventional treatment of Pulmonary Ebolism (including IVC filtration).
Dr. Weiss has mentored many Undergraduate and Masters CBID teams, and has advised on the design and development of numerous devices related to Vascular and Interventional Radiology, with a particular focus on vascular access and hemodialysis.
Dr. Weiss serves as an advisor to the Johns Hopkins Art as Applied to Medicine Program. Some examples of mentored graduate student work are listed below - please click on the hyperlinks to "experience" the content:
Embolization of Pulmonary Arteriovenous Malformations - An animation by JHU graduate student Caitlin Mock to educate patients on PAVMs. Dr. Weiss served as content advisor for this project.
Clinical Trial KeywordsObesity, Morbid Obesity, Bariatric Embolization, Bariatric Arterial Embolization, Weight Management, Endovascular Therapy
Bariatric Embolization of Arteries for the Treatment of Obesity (BEAT Obesity) Trial
The purpose of this study is to evaluate the safety and effectiveness of bariatric embolization as a minimally-invasive image-guided procedure for morbid obesity. In this procedure, specific blood vessels to the stomach are blocked in order to suppress some of the body's signals for feeling hungry, leading to weight loss.
Morbid obesity is currently treated with diet and exercise, medications, and surgery. This study is designed to help treat obesity using a minimally invasive, non-surgical, angiographic (through the blood vessel) approach. This procedure is similar to a common procedure used to treat bleeding within the stomach. This version of the procedure has been named "bariatric embolization".
Although there are over 40 hormones that limit food intake, there is only one hormone, ghrelin that has been shown to stimulate (prompt) food intake. In obese patients, eating fails to suppress ghrelin levels, which is believed to prevent feeling full after a meal and to lead to overeating. Due to the strong hunger craving effects of ghrelin, this hormone has been a target for the treatment of obesity and weight loss. More recently, ghrelin has been shown to have a significant role in the long-term effect of weight loss in bariatric (obesity) surgery where ghrelin levels are shown to be much lower when compared to untreated patients.
Recent data collected in animals has shown that blocking blood vessels to a particular portion of the stomach (bariatric embolization) can temporarily decrease levels of the appetite inducing hormone ghrelin, and decrease short-term weight gain. In a study of 5 people, there was a decrease in ghrelin levels and weight loss in the first 6 months after the procedure, but there is no information about the effects of the procedure over longer periods of time.
We hope to learn if bariatric embolization results in safe and effective weight loss in people who are morbidly obese.
For Queries: email BEATObesity@jhmi.edu or call 410-502-5118.
Activities & Honors
- American College of Radiology (ACR)
- American Roentgen Ray Society (ARRS)
- Association of University Radiologists (AUR)
- International Society for Magnetic Resonance in Medicine (ISMRM)
- International Society for the Study of Vascular Anomalies (ISSVA)
- Radiology Society of North America (RSNA)
- Society of Interventional Radiology (SIR)
- The Cardiovascular and Interventional Radiological Society of Europe (CIRSE)
Videos & Media
Recent News Articles and Media Coverage
- New Treatment For Obesity Promotes Safely Controlled Weight Loss And Appetite Suppression, Johns Hopkins Medicine, (April, 2019)
- Bariatric Embolization: Are Patients Actually Losing Weight?, Endovascular Today, April 2018.
- National Institutes of Health Clinical Center Grand Rounds: The Evolving Role of the Interventional Radiologist in the Treatment of Obesity, March 7, 2018
- Small incision, big impact: New weight loss surgery being tested, WTOP, (06/15/2016)
- New No-Surgery Weight Loss Procedure Shows Promise, NBC News, (04/05/2016)
- Hunger hormone could be key to weight loss; procedure aims to block it, The Baltimore Sun, (04/03/2016)
- Precision-Targeted Low-Dose Treatment for Large Clots in the Lungs, Johns Hopkins Medicine (05/27/2015)
- Precision-Targeted Low-Dose, The Johns Hopkins Heart and Vascular Institute Cardiovascular Report (2015)
- Previous History, JHM Podcast (08/29/2014)
- BEAT Obesity, JHM Podcast (08/21/2014)
- Beat Obesity, JHM Podcast (06/06/2014)
- Obesity Intervention, JHM Podcast (03/31/2014)
- An Overview of Vascular Anomalies, Webinar (02/04/2014)
- Disguise Artists, Hopkins Medicine Magazine (02/01/2014)
- A Difficult Diagnosis, Johns Hopkins Health (01/01/2014)
- Vascular Malformation: A Rare but Treatable Condition, Physician Update (09/20/2013)
- Latest Radiology Treatments for Obesity, Medical News Today (03/29/2012)