Research Summary
Dr Stevens’ vision is to deploy Precision Medicine for the benefit of critically ill patients. His research aims to discover and validate patient-specific biological signatures associated with trauma, surgery and acute conditions such as stroke, cardiac arrest, and sepsis. To achieve this, he engages with an interdisciplinary group of basic and systems neuroscientists, biomedical and computer engineers, biostatisticians, data scientists, and neuroradiologists. Dr Stevens is the principal investigator of the Neuroimaging for Coma Emergence and Recovery (NICER) project, which examines MRI features of the brain connectome to enhance classification and prediction in patients recovering from severe brain injury. Other projects from Dr Stevens’ group analyze features captured through neurophysiologic monitoring, structural and functional MRI of the brain, serum biomarkers and wearable sensors, with the goal of enhancing classification and prediction in vulnerable, acutel ill patients. In the lab, Dr Stevens’ group studies molecular and cellular determinants of injury and recovery in experimental models of traumatic brain injury, stroke, and sepsis, with a special emphasis on neuro-immunological responses and cellular regeneration.
Lab Website: Peter van Zijl Laboratory
Technology Expertise Keywords
Precision Heath; Big Data; Computational Medicine; Brain Mapping
Clinical Trial Keywords
Traumatic brain injury, cardiac arrest, hypoxic-ischemic encephalopathy, stroke, subarachnoid hemorrhage, intracerebral hemorrhage, delirium, encephalopathy
Selected Publications
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Sair HI, Hannawi Y, Li S, Kornbluth J, Vanhaudenhuyse A, Laureys S, Chabanne R, Jean B, Benali H, Perlbarg V, Luyt CE, Galanaud D, Velly L, Puybasset L, Pekar J, Caffo B, Stevens RD. Early functional connectome integrity and one-year recovery in comatose survivors of cardiac arrest. Radiology 2017; 162161. doi: 10.1148/radiol.2017162161
Hannawi Y, Lindquist MA, Caffo BS, Sair HI, and Stevens RD. Resting brain activity in humans with consciousness disorders: Systematic review and meta-analysis. Neurology 2015;84:1272-128
Hinson H, Puybasset L, Weiss N, Perlbarg V, Benali H, Galanaud D, Lasarev M, Stevens RD, for the Neuro Imaging for Coma Emergence and Recovery (NICER) Consortium. Neuroanatomical basis of paroxysmal sympathetic hyperactivity: a diffusion tensor imaging analysis. Brain Injury 2015;29:455-61
Salluh JIF, Wang H, Schneider E, Nagarajan N, Yenokyan G, Damluji A, Serafim RB, Stevens RD. The Outcome of Delirium in Critically Ill Patients: A Systematic Review and Meta-analysis. Br Med J. 2015;350:h253
Schneider EB, Sur S, Raymont V, Duckworth J, Kowalski R, Efron DT, Hui X, Selvarajah S, Hambridge HL, Stevens RD. Functional recovery after moderate/severe traumatic brain injury: a role for cognitive reserve? Neurology 2014; 82:1636-42
Patient Ratings & Comments
The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
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