I Want To...
I Want To...
Find Research Faculty
Enter the last name, specialty or keyword for your search below.
School of Medicine
I Want to...
C. John Sperati, M.D., M.H.S.
Christopher John Sperati, M.D., M.H.S.
Director, Nephrology Fellowship Training Program
Associate Professor of Medicine
Expertise: Atherosclerotic Renovascular Disease, Atypical Hemolytic Uremic Syndrome (aHUS), Electrolyte Disorders, Fibromuscular Dysplasia (FMD), Glomerulonephritis, Hyperaldosteronism, Hypertension, Nephrology, Renal Artery Disease ...read more
Research Interests: Fibromuscular Dysplasia; Thrombotic microangiopathy; Atypical hemolytic uremic syndrome
Request an Appointment
I live in Maryland
Request an appointment through My
I live outside of Maryland
I live outside of the United States
Dr. C. John Sperati is an Associate Professor of Medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include renal medicine.
Dr. Sperati is Director of the Nephrology Fellowship Training Program and Associate Program Director of the Osler Medical Housestaff/Residency Training Program at the Johns Hopkins University School of Medicine. He also serves as the Firm Faculty Leader of the Barker Firm. In addition, he co-directs the Johns Hopkins Osler Learning Initiative which brings the principles of medical residency training to executive education worldwide.
He obtained his medical degree from The Pennsylvania State University College of Medicine and a Master in Health Science from the Johns Hopkins Bloomberg School of Public Health. He completed an internship and residency in Internal Medicine at the Johns Hopkins Hospital, followed by a year as an Assistant Chief of Service (chief resident). He subsequently pursued subspecialty training in nephrology at the Johns Hopkins Hospital and joined the faculty in the Division of Nephrology. He is board certified in Internal Medicine and Nephrology.
Dr. Sperati’s clinical interests are in thrombotic microangiopathy including atypical hemolytic uremic syndrome (aHUS), complement mediated kidney diseases including C3 glomerulopathy, secondary and resistant hypertension (fibromuscular dysplasia, atherosclerotic renal arterial disease, hyperaldosteronism, and genetic hypertensive syndromes), glomerulonephritis (e.g., IgA nephropathy, MPGN), and nephrotic syndromes (e.g., FSGS, membranous, minimal change, amyloidosis, and others). He is the site principal investigator for several clinical studies, serves on editorial boards, and is a member of the National Kidney Foundation Education Committee as well as the Nephrology Knowledge Check-in Committee of the American Board of Internal Medicine. His clinical expertise has been recognized by induction into the Miller Coulson Academy of Clinical Excellence.
- Director, Nephrology Fellowship Training Program
- Associate Program Director for Competeny and Accreditation, Osler Medical Housestaff/Residency Training Program
- Co-Director, Johns Hopkins Osler Learning Initiative
- Associate Professor of Medicine
Centers & Institutes
- MD, Penn State College of Medicine (2000)
- Johns Hopkins University School of Medicine / Medicine (2003)
- Johns Hopkins University School of Medicine / Nephrology (2004)
- Johns Hopkins University School of Medicine / Nephrology (2007)
- American Board of Internal Medicine / Internal Medicine (2003)
- American Board of Internal Medicine / Nephrology (2007)
Research & Publications
Clinical Trial KeywordsFSGS, IgA, minimal change, membranous, aHUS, hemolytic uremic syndrome, C3 glomerulopathy
ACH471-204 A Phase 2, Proof-of-Concept, Randomized, Double-Blinded, Placebo-Controlled Study of ACH-0144471 Treatment for 6 Months in Patients with C3 Glomerulopathy (C3G)
International aHUS Registry
Selected PublicationsView all on Pubmed
Gavriilaki E, Yuan X, Ye Z, Ambinder AJ, Shanbhag SP, Streiff MB, Kickler TS, Moliterno AR, Sperati CJ, Brodsky RA. "Modified Ham test for atypical hemolytic uremic syndrome." Blood. 2015 Jun 4;125(23):3637-46. doi: 10.1182/blood-2015-02-629683. Epub 2015 Apr 10.
Sperati CJ, Moliterno AR. "Thrombotic microangiopathy: focus on atypical hemolytic uremic syndrome." Hematol Oncol Clin North Am. 2015 Jun;29(3):541-59. doi: 10.1016/j.hoc.2015.02.002. Epub 2015 Apr 4.
Sperati CJ, Whaley-Connell A. "Secondary hypertension: beginnings and transitions." Adv Chronic Kidney Dis. 2015 May;22(3):177-8. doi: 10.1053/j.ackd.2015.03.001.
Vernon HJ, Sperati CJ, King JD, et al. "A detailed analysis of methylmalonic acid kinetics during hemodialysis and after combined liver/kidney transplantation in a patient with mut0 methylmalonic academia." J Inherit Metab Dis. 2014 Nov; 37(6): 899–907. doi:10.1007/s10545-014-9730-7.
Foy M, Sperati CJ, Lucas GM, Estrella MM. "Drug interactions and antiretroviral drug monitoring." Curr HIV/AIDS Rep. 2014 Sep;11(3):212-22. doi: 10.1007/s11904-014-0212-1.
Amir A Naderi; Brian A Houston; C John Sperati; All wrapped up and nowhere to flow. The American journal of medicine 2012;125(9):876-9. 2012
Elizabeth George; Girish N Nadkarni; Michelle M Estrella; Gregory M Lucas; C John Sperati; Mohamed G Atta; Derek M Fine; The impact of hepatitis C coinfection on kidney disease related to human immunodeficiency virus (HIV): a biopsy study. Medicine 2011;90(5):289-95. 2011
C John Sperati; Michael B Streiff; Acute renal failure in a patient with antiphospholipid syndrome and immune thrombocytopenic purpura treated with eltrombopag. American journal of hematology 2010;85(9):724-6. 2010
C John Sperati; Nada Alachkar; Ronald Rodriguez; Mark Haas; Michael J Choi; Incidental discovery of a renal cell carcinoma on native kidney biopsy. American journal of kidney diseases : the official journal of the National Kidney Foundation 2010;56(1):175-80. 2010
Michelle M Estrella; Chistopher J Sperati; Wen H L Kao; Rulan S Parekh; Genetic epidemiology of chronic kidney disease. Current opinion in nephrology and hypertension 2010;19(3):283-91. 2010
Joshua F Zeidner; Edwin J Ostrin; Emily Sydnor; Derek Fine; C John Sperati; The tissue's the issue. The American journal of medicine 2010;123(5):420-2. 2010
Sayed Tabatabai; C John Sperati; Mohamed G Atta; Kashif Janjua; Christopher Roxbury; Gregory M Lucas; Derek M Fine; Predictors of complication after percutaneous ultrasound-guided kidney biopsy in HIV-infected individuals: possible role of hepatitis C and HIV co-infection. Clinical journal of the American Society of Nephrology : CJASN 2009;4(11):1766-73. 2009
C John Sperati; Rulan S Parekh; Yvette Berthier-Schaad; Bernard G Jaar; Laura Plantinga; Nancy Fink; Neil R Powe; Michael W Smith; Josef Coresh; W H Linda Kao; Association of single-nucleotide polymorphisms in JAK3, STAT4, and STAT6 with new cardiovascular events in incident dialysis patients. American journal of kidney diseases : the official journal of the National Kidney Foundation 2009;53(5):845-55. 2009
C John Sperati; Nisha Aggarwal; Aravind Arepally; Mohamed G Atta; Fibromuscular dysplasia. Kidney international 2009;75(3):333-6. 2009
Priscilla K Brastianos; Jordan W Swanson; Michael Torbenson; John Sperati; Petros C Karakousis; Tuberculosis-associated haemophagocytic syndrome. The Lancet infectious diseases 2006;6(7):447-54. 2006
C D Collard; A Väkevä; C Büküsoglu; G Zünd; C J Sperati; S P Colgan; G L Stahl; Reoxygenation of hypoxic human umbilical vein endothelial cells activates the classic complement pathway. Circulation 1997;96(1):326-33. 1997
Contact for Research Inquiries
1830 E. Monument St.
Baltimore, MD 21287 map
Activities & Honors
- Fellow, National Kidney Foundation
- Member, Miller Coulson Academy of Clinical Excellence
- American Society of Nephrology
- National Kidney Foundation
- Member, Faculty Senate, Johns Hopkins
- Firm Faculty Leader, The Barker Firm