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Clifford Mitsuo Takemoto, M.D.

Photo of Dr. Clifford Mitsuo Takemoto, M.D.


Expertise: Hematology, Oncology, Pediatric Hematology Oncology

Research Interests: Hemophilia; Sickle Cell Anemia; Thrombosis; Mast cells; Bone marrow failure, White cell disorders, Vascular malformations; von Willebrand disease more

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The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-955-6132

1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-6132
Fax: 410-955-8208


Dr. Clifford M. Takemoto is an associate professor of pediatrics at the Johns Hopkins University School of Medicine. A pediatric oncologist and physician scientist, Dr. Takemoto’s clinical and research interests include cancers of the blood, hemophilia, sickle cell disease, thrombosis, von Willebrand disease, anemia, bone marrow failure, mast-cell disorders, white-cell disorders/neutropenia and vascular malformations.

Dr. Takemoto earned his medical degree at the University of California, Irvine School of Medicine. He completed a pediatrics residency at Children's Hospital Los Angeles, an oncology fellowship at Tokyo’s National Children's Medical Research Center and a pediatric hematology/oncology fellowship at the Dana-Farber Cancer Institute.

Prior to joining the Johns Hopkins faculty in 1999, he was an instructor in pediatric hematology/oncology at Harvard Medical School. In addition to his duties at Johns Hopkins, Dr. Takemoto also serves as an adjunct investigator in pediatric oncology at the National Cancer Institute.

Dr. Takemoto is a member of the American Association of Immunologists, the American Society of Hematology, and the American Society of Pediatric Hematology/Oncology. more

Departments / Divisions



  • MD, University of California at Irvine School of Medicine - REGISTRAR (1989)


  • Children's Hospital Los Angeles / Pediatrics (1992)


  • Dana-Farber Cancer Institute / Pediatric Hematology-Oncology (1996)

Board Certifications

  • American Board of Pediatrics / Hematology-Oncology (1998)

Research & Publications

Selected Publications

Takemoto,C.M. (2009). Rituximab for ITP: a long-term fix? Pediatr. Blood Cancer 52, 155-156.

Strouse,J.J., Tamma,P., Kickler,T.S., and Takemoto,C.M. (2009). D-dimer for the diagnosis of venous thromboembolism in children. Am. J. Hematol. 84, 62-63.

Takemoto,C.M., Lee,Y.N., Jegga,A.G., Zablocki,D., Brandal,S., Shahlaee,A., Huang,S., Ye,Y., Gowrisankar,S., Huynh,J., and McDevitt,M.A. (2008). Mast cell transcriptional networks. Blood Cells Mol. Dis. 41, 82-90.

Khan,J.U., Takemoto,C.M., Casella,J.F., Streiff,M.B., Nwankwo,I.J., and Kim,H.S. (2008). Catheter-directed thrombolysis of inferior vena cava thrombosis in a 13-day-old neonate and review of literature. Cardiovasc. Intervent. Radiol. 31 Suppl 2, S153-S160.

Gamper,C.J., Takemoto,C.M., Schowinsky,J., Borowitz,M.J., Horwitz,M.S., and Strouse,J.J. (2008). Lymphadenopathy as the primary manifestation of malignant transformation in two patients with severe congenital neutropenia. Pediatr. Blood Cancer 50, 1072-1075.

Farrar,J.E., Nater,M., Caywood,E., McDevitt,M.A., Kowalski,J., Takemoto,C.M., Talbot,C.C., Jr., Meltzer,P., Esposito,D., Beggs,A.H., Schneider,H.E., Grabowska,A., Ball,S.E., Niewiadomska,E., Sieff,C.A., Vlachos,A., Atsidaftos,E., Ellis,S.R., Lipton,J.M., Gazda,H.T., and Arceci,R.J. (2008). Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Blood 112, 1582-1592.

Strouse,J.J., Takemoto,C.M., Keefer,J.R., Kato,G.J., and Casella,J.F. (2008). Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. Pediatr. Blood Cancer 50, 1006-1012.

Savage,W.J., Kickler,T.S., and Takemoto,C.M. (2007). Acquired coagulation factor inhibitors in children after topical bovine thrombin exposure. Pediatr. Blood Cancer 49, 1025-1029.

Shahlaee,A.H., Brandal,S., Lee,Y.N., Jie,C., and Takemoto,C.M. (2007). Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells. J. Immunol. 178, 378-388.

Takemoto,C. (2005). Sickle cell disease: matters of the heart. Pediatr. Blood Cancer 45, 870-871.

Clauss,S.B., Manco-Johnson,M.J., Quivers,E., Takemoto,C., and Spevak,P.J. (2003). Primary antiphospholipid antibody syndrome and cardiac involvement in a child. Pediatr. Cardiol. 24, 292-294.

Takemoto,C.M., Yoon,Y.J., and Fisher,D.E. (2002). The identification and functional characterization of a novel mast cell isoform of the microphthalmia-associated transcription factor. J. Biol. Chem. 277, 30244-30252.

Weilbaecher,K.N., Motyckova,G., Huber,W.E., Takemoto,C.M., Hemesath,T.J., Xu,Y., Hershey,C.L., Dowland,N.R., Wells,A.G., and Fisher,D.E. (2001). Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice. Mol. Cell 8, 749-758.

Wu,M., Hemesath,T.J., Takemoto,C.M., Horstmann,M.A., Wells,A.G., Price,E.R., Fisher,D.Z., and Fisher,D.E. (2000). c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev. 14, 301-312.

Takeda,K., Takemoto,C., Kobayashi,I., Watanabe,A., Nobukuni,Y., Fisher,D.E., and Tachibana,M. (2000). Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance. Hum. Mol. Genet. 9, 125-132.

Dharnidharka,V.R., Takemoto,C., Ewenstein,B.M., Rosen,S., and Harris,H.W. (1998). Membranous glomerulonephritis and nephrosis post factor IX infusions in hemophilia B. Pediatr. Nephrol. 12, 654-657.

Weilbaecher,K.N., Hershey,C.L., Takemoto,C.M., Horstmann,M.A., Hemesath,T.J., Tashjian,A.H., and Fisher,D.E. (1998). Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. J. Exp. Med. 187, 775-785.

Hemesath,T.J., Price,E.R., Takemoto,C., Badalian,T., and Fisher,D.E. (1998). MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 391, 298-301.

Ewenstein,B.M., Takemoto,C., Warrier,I., Lusher,J., Saidi,P., Eisele,J., Ettinger,L.J., and DiMichele,D. (1997). Nephrotic syndrome as a complication of immune tolerance in hemophilia B. Blood 89, 1115-1116.

Takemoto,C. and Fisher,D.E. (1995). Structural constraints for DNA recognition by Myc and other b-HLH-ZIP proteins: design of oncoprotein analogues. Gene Expr. 4, 311-317.

Activities & Honors


  • American Association of Immunologists
  • American Society of Hematology
  • American Society of Pediatric Hematology/Oncology

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