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Vsevolod Y Polotsky, M.D., Ph.D.

Photo of Dr. Vsevolod Y Polotsky, M.D., Ph.D.
  • Director, Sleep Basic Research
  • Professor of Medicine
Male

Languages: English, Russian

Expertise

Critical Care Medicine, Pulmonary Disease and Critical Care Medicine, Pulmonary Medicine, Sleep Medicine

Research Interests

Hypoxia; Obesity; Metabolic Syndrome; Obstructive Sleep Apnea

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Insurance Information

Maryland

410-550-5864

Outside of Maryland

410-464-6641
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International Patients

+1-410-502-7683
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Locations

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864
4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-9434

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-3467
601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-955-9434

The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-955-3467
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map

Background

Dr. Polotsky is a pulmonary, critical care, and sleep medicine physician.  He is an expert in the diagnosis and treatment of sleep disordered breathing.  He provides teaching to medical students, residents, pulmonary and sleep fellows at Johns Hopkins. Dr. Polotsky oversees research training of sleep fellows across the Johns Hopkins University as the PI of the sleep training grant.

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Titles

  • Director, Sleep Basic Research
  • Professor of Medicine

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, Pavlov State Medical University (1984)

Residencies

  • Pavlov State Medical University / Infectious Diseases (1986)
  • Norwalk Hospital / Internal Medicine (1998)

Fellowships

  • Weizmann Institute Weinberg Graduate School (1991)
  • Johns Hopkins University School of Medicine / Medicine (2002)

Board Certifications

  • American Board of Internal Medicine / Pulmonary Disease (2002)

Research & Publications

Research Summary

Obstructive sleep apnea (OSA) is a highly prevalent disease affecting 25-30% of the adult population and more than 50% of obese individuals. OSA is a major cause of morbidity and mortality in Western society. OSA plays a major role in the development and progression of cardiovascular, neurocognitive, and metabolic diseases. Dr. Polotsky has made major contributions to understanding of cardiovascular and metabolic consequences of OSA.  He has developed several animal models of OSA, including a high throughput mouse model of intermittent hypoxia mimicking the oxyhemoglobin profile in patients with OSA. Using this model, Dr. Polotsky has made several seminal discoveries.  Specifically, he has demonstrated that intermittent hypoxia induces insulin resistance and glucose intolerance, especially in obese mice and that effects of intermittent hypoxia and sleep apnea on glucose metabolism are mediated by the sympathetic nervous system via the carotid bodies. Dr. Polotsky has also shown that intermittent hypoxia induces proatherogenic dyslipidemia by inhibiting lipoprotein clearance, and increases hepatic lipid biosynthesis leading to hepatic steatosis and steatohepatitis.  Moreover, he was also first to demonstrate that intermittent hypoxia greatly accelerates the progression of atherosclerosis. His discoveries were confirmed by many laboratories and have been cited numerous times in major reviews and textbooks.  Dr. Polotsky’s group and other investigators convincingly demonstrated the relevance of his experimental findings for human disease.  Most recently, Dr. Polotsky’s research has focused on the pathogenesis of obstructive sleep apnea and specifically on molecular signaling in the hypothalamus, medulla and the carotid body contributing to the pathogenesis of sleep disordered breathing.

Lab Website: Polotsky Research Lab

Activities & Honors

Honors

  • Special Invited Speaker, French Sleep Research Society Congress, Marseille, France, 2013
  • Member, American Thoracic Society, Board of Directors, 2013
  • Chair, Sleep and Respiratory Neurobiology Assembly, American Thoracic Society, 2013
  • Keynote Speaker, 9th Annual Center for Sleep and Circadian Neurobiology Research Retreat at the University of Pennsylvania in Philadelphia, 2012
  • Chair, Planning Committee, Sleep and Respiratory Neurobiology Assembly, American Thoracic Society, 2010 - 2012
  • Fellow, American Academy of Sleep Medicine (FAASM), 2009
  • Chair, Program Committee, Sleep and Respiratory Neurobiology Assembly, American Thoracic Society, 2009 - 2010
  • ATS International Conference Best Abstract of the, Respiratory Neurobiology and Sleep Assembly, 2008
  • Beginning Grant-In-Aid, American Heart Association, 2007
  • Best Poster, 10th International Conference on Sleep and Breathing, Palm Cove, Australia, 2007
  • Young Investigator Award, Respiratory Neurobiology and Sleep Assembly, ATS, 2006
  • R01, NIH, NHLBI, 2005
  • ATS International Conference Best Abstract of the Respiratory Neurobiology and Sleep Assembly, 2003
  • K08 Mentored Clinical Scientist Development Award, 2002
  • Respiratory Neurobiology and Sleep Assembly Travel Award, 1999
  • National Research Service Award, 1998
  • Physician Recognition Award, 1998
  • Physician Recognition Award, 2000
  • Medical Diploma cum laude (USSR), 1984
  • State award for academic achievements (USSR), 1981
  • Special stipend for academic excellence (USSR), 1978 - 1984
  • Conference Best Abstract (Respiratory Neurobiology and Sleep Assembly), ATS International, 2008
  • Fellow, American Heart Association, 2006

Memberships

  • American Academy of Sleep Medicine, 2003
    Fellow
  • American Heart Association, 2006
  • American Medical Association, 1998
  • American Thoracic Society, 1999
    International Conference Committee, American Thoracic Society, 2008-2010; Chair, Planning Committee, Sleep and Respiratory Neurobiology Assembly, 2010-2012, Chair, 2013; Board of Directors, 2013-2015

Professional Activities

  • Fellow, American Academy of Sleep Medicine, 2003
  • Chair, American Thoracic Society, 2009
  • Chair, American Thoracic Society, 2010
  • Chair, American Thoracic Society, 2013
  • Chair-Elect, American Thoracic Society, 2008
  • Board of Directors, American Thoracic Society, 2013
  • Chair, Sleep and Respiratory Neurobiology Assembly, American Thoracic Society, 2013
  • Chair, Planning Committee, Sleep and Respiratory Neurobiology Assembly, American Thoracic Society, 2010
  • Chair, Program Committee, Sleep and Respiratory Neurobiology Assembly, American Thoracic Society, 2009
  • International Conference Committee, American Thoracic Society, 2008
  • Chair, Planning Committee, Sleep and Respiratory Neurobiology Assembly, American Thoracic Society, 2010

Videos & Media

Lectures and Presentations

  • Visiting Professor
    Pittsburg, PA (01/01/2004)
    University of Pittsburg School of Medicine
  • Johns Hopkins Bloomberg School of Public Health
    Baltimore, MD (01/01/2004)
  • 9th International Symposium on Sleep and Breathing
    Newport, RI (01/01/2004)
  • University of Maryland School of Medicine
    Baltimore, MD (01/01/2005)
  • Visiting Professor
    Chicago, IL (01/01/2005)
    University of Chicago School of Medicine
  • Visiting Professor
    Cleveland, OH (01/01/2005)
    Case Western Reserve University
  • Founding Congress of the World Association of Sleep Medicine (WASM)
    Berlin, Germany (01/01/2005)
  • Sleep, Breathing and Metabolic Function
    ATS International Conference, San Diego, CA (01/01/2006)
  • Clinical Nutrition Research Center
    Birmingham, AL (01/01/2006)
    University of Alabama at Birmingham
  • Center for Narcolepsy and Sleep Research University of Illinois at Chicago
    Chicago, IL (01/01/2006)
  • GRECC and CNRU Joint Seminar
    Baltimore, MD (01/01/2006)
    University of Maryland
  • SLEEP 2006 20th Anniversary Meeting of the Associated Professional Sleep Societies
    Salt Lake City, Utah (01/01/2006)
  • Pennsylvania State College of Medicine
    Hershey, PA (01/01/2006)
  • University of Rochester
    Rochester, NY (01/01/2006)
  • Cincinnati Children''s Hospital Medical Center
    Cincinnati, OH (01/01/2006)
  • the Rappoport Faculty of Medicine
    Haifa, Israel (01/01/2007)
    Technion
  • Symposium ‘Sleep Apnea as a Mechanism of Atherosclerosis: from Bench to Bedside’
    ATS International Conference, Toronto, Canada (01/01/2008)
  • Annual Meeting of the Associated Professional Sleep Societies
    Baltimore, MD (01/01/2008)
  • Symposium ‘Oxidative Stress and Inflammation in Obstructive Sleep Apnea’
    Montreal, Canada (01/01/2008)
    Meakins-Christie Laboratories, McGill University
  • Asian-Pacific Society of Respirology
    Bangkok, Thailand (01/01/2008)
  • Ohio State University
    Columbus, OH (01/01/2009)
  • Hypoxia and Hypercapnia in Sleep: the Good and the Bad
    Symposium, ATS International Conference, San Diego, CA (01/01/2009)
  • Metabolic Syndrome and Respiratory Disorders
    Symposium, ATS International Conference, San Diego, CA (01/01/2009)
  • Inflammatory Mediators and Chronic Inflammation in Sleep Pathology
    Seattle, WA (01/01/2009)
    SLEEP
  • Henry Ford Hospital, Detroit, MI (01/01/2009)
  • Data from Animal Models: role of IH and obesity
    Intermittent Hypoxia and Adipose Tissue, Palermo, Italy (01/01/2009)
  • CPAPA treatment: effects on plasma lipids and liver function
    Intermittent Hypoxia and Adipose Tissue, Palermo, Italy (01/01/2009)
  • the Rappoport Faculty of Medicine, Haifa, Israel (01/01/2009)
    Technion
  • the Johns Hopkins Bayview Medical Center Medical Grand Rounds
    Baltimore, MD (01/01/2009)
  • Allergy and Clinical Immunology Research Conference
    Baltimore, MD (01/01/2010)
    The Johns Hopkins Bayview Medical Center
  • Lung Research Conference, Baltimore, MD (01/01/2010)
    The Johns Hopkins University School of Medicine
  • Acute Neuroscience Seminar, Baltimore, MD (01/01/2010)
    The Johns Hopkins University School of Medicine
  • Obesity in Pulmonary Medicine
    Symposium, ATS International Conference, New Orleans, LA (01/01/2010)
  • Should We Treat Asymptomatic OSA patients
    Symposium, New Orleans, LA (01/01/2010)
  • NHLBI workshop ’Defining molecular pathways and mechanisms that predict CVD risk associated with SDB’
    Bethesda, MD (01/01/2010)
  • Obesity and Obstructive Sleep Apnoea: Interacting Actors
    Symposium, Lisbon, Portugal (01/01/2010)
    20th Congress of the European Sleep Research Society
  • Visiting Professor
    Indiana University, Indianapolis, IN (01/01/2010)
  • University of Pittsburgh
    Pittsburgh, PA (01/01/2010)
  • Norwalk Hospital
    Norwalk, Ct (01/01/2011)
  • Physiology of Intermittent Hypoxia
    ATS International Conference, Denver, Co (01/01/2011)
  • Consequences of Intermittent Hypoxia
    ATS International Conference, Denver, Co (01/01/2011)
  • Intermittent hypoxia model and clinical trials: evidence regarding cardiovascular and metabolic morbidities in sleep apnea
    Symposium, World Sleep, Japan, Kyoto (10/01/2011)
  • Molecular effects of Obstructive Sleep Apnea: Summary and Perspectives
    Symposium, World Sleep, Japan, Kyoto (10/01/2011)
  • Risks, Benefits, and Challenges of Human Research in Sleep Apnea
    Baltimore, MD (03/01/2012)
  • Keynote Speaker, 9th Annual Center for Sleep and Circadian Neurobiology Research Retreat, Pennsylvania, PA (06/09/2012)
    University of Pennsylvania in Philadelphia
  • 21st Congress of the European Sleep Research Society
    Paris, France (01/01/2012)
  • Joseph Fourier University of Grenoble
    Grenoble, France (01/01/2012)
  • Guest Lecturer
    Montreal, Canada (01/01/2013)
    McGill University Health Centre Research Institute
  • Experimental Biology 2013
    Boston, MA (01/01/2013)
  • Obesity and Metabolism: An Emerging Frontier in Health and Disease
    Burlington, VT (01/01/2013)
  • Asian Pacific Society of Respirology
    Yokohama, Japan (01/01/2013)
  • Keynote Speaker, Marseille, France (01/01/2013)
    French Sleep Research Society Congress
  • Keynote Speaker, Marseille, France (01/01/2013)
    French Sleep Research Society Congress
  • Acute Neuroscience Seminar, Baltimore, MD (01/01/2010)
    The Johns Hopkins University School of Medicine

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