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Matthews Chacko, M.D.

Photo of Dr. Matthews Chacko, M.D.
  • Medical Advisor, Johns Hopkins Comprehensive Transplant Center
  • Assistant Professor of Medicine


Acute Myocardial Infarction (AMI), Cardiac Catheterization, Cardiovascular Diseases, Cardiovascular Interventions, Carotid Artery Disease, Carotid Artery Stenosis, Carotid Artery Stenting, Chronic Total Coronary Occlusion, Chronic Total Occlusions, Circulatory Support Devices, Coronary Angiography, Coronary Artery Disease, Coronary Artery Stenting, Coronary Care Unit, Emboli-Protection Devices, Endovascular Therapies, Fractional Flow Reserve, Heart Disease, Hypertension, Interventional Cardiology, Intravascular Ultrasound (IVUS), Invasive Cardiology, Laser Atherectomy, Lower Extremity Revascularization, Pericardiocentesis, Peripheral Angiography, Peripheral Arterial Disease (PAD), Peripheral Vascular Disease, Renal Artery Disease, Restenosis, Rotational Atherectomy, Trans-Radial Intervention, Valvular Heart Disease, Valvuloplasty for Valvular Stenosis more

Research Interests

Renal Artery Stenosis; Valvular Heart Disease; Myocardial Infarction; Refractory Hypertension; Coronary Artery Disease; Peripheral Arterial Disease; Carotid Artery Disease; Acute Coronary Syndromes; Stents; Cardiac Critical Care; Endovascular Interventions; Percutaneous Coronary Intervention more

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The Johns Hopkins Hospital (Main Entrance)

Appointment Phone: 410-502-9384
1800 Orleans St.
Sheikh Zayed Tower, Suite 7125V
Baltimore, MD 21287 map
Phone: 410-502-9384 | Fax: 410-367-2224

Johns Hopkins Outpatient Center

Appointment Phone: 410-502-9384
601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-502-9384 | Fax: 410-367-2224


Dr. Matthews Chacko is faculty for interventional cardiologist for the Coronary Care Unit, the Tayer Firm of the Osler and Director of peripheral vascular interventions at the Johns Hopkins Hospital. He specializes in using minimally invasive cardiovascular procedures to help patients who have had a heart attack or are at high risk for one. Dr. Chacko also performs minimally invasive aortic valve replacement (TAVR) surgery. As an assistant professor of medicine, he mentors students to be compassionate practitioners in times of crisis for patients and their families.

Dr. Chacko received his bachelor’s degree from Azusa Pacific University in California and his medical degree from the University of Kansas. He completed his residency at Johns Hopkins and his cardiology fellowship at the Cleveland Clinic. He joined the Johns Hopkins faculty in 2005 as an assistant professor of medicine at the Heart and Vascular institute. Dr. Chacko’s research interests involve finding safer and more effective interventions for cardiovascular diseases. more


  • Medical Advisor, Johns Hopkins Comprehensive Transplant Center
  • Assistant Professor of Medicine

Departments / Divisions

Centers & Institutes



  • MD, University of Kansas School of Medicine (1998)


  • Johns Hopkins University School of Medicine / Medicine (2001)


  • Cleveland Clinic / Cardiology (2005)
  • Cleveland Clinic / Interventional Cardiology (2007)

Board Certifications

  • American Board of Internal Medicine / Cardiovascular Disease (2005)
  • American Board of Internal Medicine / Interventional Cardiology (2006)

Research & Publications

Selected Publications

Aaron Horne Jr.; Elizabeth A. Reineck; Rani K. Hasan; Jon R. Resar; Matthews Chacko. Transcatheter aortic valve replacement: Historical perspectives, current evidence, and future directions. American Heart Journal. 2014.

Aaron Horne; Matthews Chacko. Thrombectomy Devices in Coronary Intervention. Interventional Cardiology Clinics. 2013;2(2):347-359.

Michael J. Blaha; Gurusher Panjrath; Matthews Chacko; Steven P. Schulman. Localized calcific constrictive pericarditis masquerading as a basal aneurysm. Journal of the American College of Cardiology. 2011;57(18):e65.

Catherine Y. Campbell; Ashish S. Shah; Matthews Chacko. Inducible left ventricular obstruction after apical-conduit aortic valve bypass surgery. Journal of Thoracic and Cardiovascular Surgery. 2010;140(3):e62-e63.

Ming Zhang; Niladri Mal; Matthew Kiedrowski; Matthews Chacko; Arman T. Askari; Zoran B. Popovic; Omer N. Koc; Marc S. Penn. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB Journal. 2007;21(12):3197-3207.

Stephen G. Ellis; Marc S. Penn; Brian Bolwell; Mario Garcia; Matthews Chacko; Thomas Wang; Kelly J. Brezina; Gerry McConnell; Eric J. Topol. Granulocyte colony stimulating factor in patients with large acute myocardial infarction: Results of a pilot dose-escalation randomized trial. American Heart Journal. 2006;152(6):1051.e9-1051.e14.

Matthews Chacko; A. Michael Lincoff; Katherine E. Wolski; David J. Cohen; John A. Bittl; Alexandra J. Lansky; Yoshihiro Tsuchiya; Amadeo Betriu; Michael H. Yen; Derek P. Chew; et al. Ischemic and bleeding outcomes in women treated with bivalirudin during percutaneous coronary intervention: A subgroup analysis of the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)-2 trial. American Heart Journal. 2006;151(5):1039.e1-1039.e7.

Matthews Chacko; Bruce W Lytle; Richard D White; Robert E Hobbs. Images in cardiovascular medicine. A "mickey mouse" coronary anomaly: aorto-left atrial fistula with aneurysm. Circulation. 2005;111(12):e162-163.

Matthews Chacko; Nassir F. Marrouche; Deepak L. Bhatt. Asymptomatic acute inferior ST elevation myocardial infarction from thermal injury complicating radiofrequency ablation for atrioventricular re-entrant tachycardia. Journal of Invasive Cardiology. 2004;16(9):504-505.

Activities & Honors


  • Alpha Omega Alpha (AOA), University of Kansas, 1997
  • Distinguished Alumnus of the Year, Azusa Pacific University, 2013

Professional Activities

  • Member, Cardiac and Renal Drug Advisory Committee, Food and Drug Administration (FDA)

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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