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James Richard Eshleman, Jr, M.D., Ph.D.

Photo of Dr. James Richard Eshleman, Jr, M.D., Ph.D.
  • Associate Director, Molecular Diagnostics Laboratory
  • Professor of Pathology
Male

Expertise

Pathology

Research Interests

Molecular diagnosis of cancer; Genetic instability; Pancreatic cancer genetics and chemosensitivity

Locations

The Johns Hopkins Hospital

600 N. Wolfe Street David H. Koch Cancer Research Building, Suite 344 Baltimore, MD 21287 map
Phone: 410-955-9790 | Fax: 410-614-0671

Background

Dr. James Eshleman is a professor of pathology and oncology at the Johns Hopkins University School of Medicine and a member of its Kimmel Cancer Center. His areas of clinical expertise includes molecular diagnosis. Dr. Eshleman serves as the associate director of the Molecular Diagnostics Laboratory at the Johns Hopkins School of Medicine.
 
Dr. Eshleman earned his M.D. and Ph.D. from the University of Pennsylvania School of Medicine. He completed a residency in clinical pathology and a fellowship in blood banking and transfusion medicine at the Hospital of the University of Pennsylvania.
 
His research interests include studying the genetics of hereditary and sporadic pancreatic cancers; using genetics to develop personalized chemotherapy regimens and other treatments for pancreatic cancer patients; finding new ways to enable rapid drug screening for pancreatic cancer; and developing new molecular pathology tools.

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Titles

  • Associate Director, Molecular Diagnostics Laboratory
  • Professor of Pathology
  • Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD; Pathology, Hospital of the University of Pennsylvania (1988)

Residencies

  • Hospital of the University of Pennsylvania / Clinical Pathology (1992)

Fellowships

  • Hospital of the University of Pennsylvania / Blood Banking/Transfusion Medicine (1993)

Board Certifications

  • American Board of Pathology / Clinical Pathology (1992)

Research & Publications

Research Summary

Pancreatic cancers: genetics of sporadic and familial pancreatic cancer.  In collaboration with the Vogelstein/Kinzler lab, in 2008 we reported exome sequencing for 24 pancreatic cancers, where we confirmed identified genes in another 92 cancers. In Jones 2009, we identified that the partner and localizer of BRCA2 (PALB2) was a familial pancreatic cancer predisposition gene.  Using gene mutations in primary cancers and their metastases, we clocked the progression of pancreatic cancer to demonstrate that metastasis is a late event, occurring after 17 years of growth in the primary site.  Finally, in Norris et al, we reported a new method of mutagenesis in pancreatic cancer.
 
Chemotherapy of pancreatic cancer. In Cui et al, we correlated the genetics of pancreatic cancer with responses to various classes of chemotherapy.  In Kamiyama, we developed mice that are both immunodeficient and biochemically selectable.  After growth of human cancers in these mice, pure cancer cells can be routinely obtained for drug screening.
 
Novel molecular pathology tools. We wrote software to simulate pyrosequencing (Chen et al), and developed a method (haplotype counting) to overcome the error rate of next-generation sequencing (Debeljak et al).

Lab

The Pathology Molecular Diagnostics Laboratory offers state-of-the-art clinical molecular testing for leukemia, lymphoma, solid tumors, cancer predisposition and a number of hematologic mutations associated with disease. Their tests are based on the latest research-based knowledge and provide initial diagnostic information, detection of residual disease following therapy, and assessment of disease risk for inherited conditions.

The Pathology Cytogenetics Laboratory offers the most advanced clinical cytogenetics testing available for leukemia, lymphoma and solid tumors. The tests provide initial diagnostic information and minimal risidual disease detection following therapy or transplant. Expert results, interpretation and consultation services from these laboratories aid referring physicians, including oncologists, hematologists, pathologists, obstetricians and geneticists, in the appropriate diagnosis and management of their patients.

Core Facility: Molecular Pathology & Cytogenetics

Selected Publications

View all on Pubmed

Eshleman JR, Lang EZ, Bowerfind GK, Parsons R, Vogelstein B, Willson JKV, Veigl M, Sedwick WD, and Markowitz S. Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer. Oncogene. 1995; 10:33-7.

Berg KD, Brinster NK, Huhn KM, Goggins MG, Jones RJ, Makary A, Griffin CA, Rosenblum-Vos LS, Borowitz MJ, Nousari HC, and Eshleman JR. Transmission of a T-cell lymphoma by allogeneic bone marrow transplantation. New Engl J Medicine. 2001; 345:1458-63.

Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, and Kinzler KW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008; 321:1801-6. [PMC2848990].

Cui Y, Brosnan JA, Blackford A, Sur S, Hruban RH, Kinzler KW, Vogelstein B, Maitra A, Diaz LA, Iacobuzio-Donahue CA, and Eshleman JR. Genetically defined subsets of human pancreatic cancer demonstrate unique in vitro chemosensitivity. Clinical Cancer Research, 2012;18:6519-30. [PMC3513499].

Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, Zaheer A, Fisher GA, Crocenzi TS, Lee JJ, Greten TF, Duffy AG, Ciombor KK, Eyring AD, Lam BH, Joe A, Kang SP, Holdhoff M, Danilova L, Cope L, Meyer C, Zhou S, Goldberg RM, Armstrong DK, Bever KM, Fader AN, Taube J, Housseau F, Spetzler D, Xiao N, Pardoll DM, Papadopoulos N, Kinzler KW, Eshleman JR, Vogelstein B, Anders RA, Diaz LA Jr. Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 2017 July; 357: 409-413.

Academic Affiliations & Courses

Graduate Program Affiliation

Pathobiology, Cellular and Molecular Medicine

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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