Dr. Eshleman's research program includes basic, translational, and clinical research. Her basic research program is focused on HIV diversity and its impact on HIV transmission, disease progression, and treatment outcomes. Her translational research program is focused on development and evaluation of assays and laboratory methods for HIV analysis. Dr. Eshleman directs two CAP-accredited laboratories at JHU: the HIV Genotyping Laboratory and the HIV Clinical Research Laboratory. Her clinical research program is focused on HIV prevention. She is also the Director of the HPTN Laboratory Center, one of three leadership groups of the NIH-sponsored HIV Prevention Trials Network (HPTN). This network performs cohort studies and clinical trials evaluating behavioral, biomedical, and structural interventions for HIV prevention in the US, Africa, South America, Asia, and Eastern Europe. Dr. Eshleman was part of the HPTN 052 study team. This landmark clinical trial showed that early HIV treatment with antiretroviral drugs prevented >90% of sexual HIV transmissions; the finding was named "Breakthrough of the Year" in 2011 by the journal Science.
Dr. Eshleman's research program includes basic, translational, and clinical research.
Cohen M, Ying C, McCauley M, Gamble T, Hosseinipour M, Kumarasamy N, Hakim J, Kumwenda J, Grinsztejn B, Pilotto JH, Godbole S, Mehendale S, Chariyalertsak S, Santos B, Mayer K, Hoffman I, Eshleman S, Piwowar-Manning E, Wang L, Mekhema J, Mills L, De Bruyn G, Sanne I, Eron J, Gallant J, Havlir D, Swindells S, Ribaudo H, Elharrar V, Taha T, Nielsen K, Celentano D, Essex M, and Flemming T. Prevention of HIV-1 infection with antiretroviral therapy: Results from HPTN 052. New Engl J Med. 2011; 365:493-505.
Laeyendecker O, Brookmeyer R, Cousins MM, Mullis C, Konikoff J, Donnell D, Celum C, Buchbinder SP, Seage GR, Kirk GD, Mehta SH, Astemborski J, Jacobson LP, Margolick JB, Brown J, Quinn TC, and Eshleman SH. HIV incidence determination in the United States: A multi-assay approach. J Infect Dis. 2013; 207:232-239.
Coates TJ, Kulich M, Zelaya CE, Celantano DD, Chariyalertsak S, Chingono A, Gray G, Mbwambo JKK, Morin FS, Richter L, Sweat M, van Rooven H, McGrath N, Fiamma A, Laeyendecker O, Piwowar-Manning E, Szerekes G, Donnell D, and Eshleman SH. Effect of community-based voluntary counselling and testing on HIV incidence and social and behavioural outcomes (NIMH Project Accept; HPTN 043): a cluster-randomised trial. Lancet Global Health.2014. 2:e267-e277.
Fogel JM, Piwowar-Manning E, Donohue K, Cummings V, Marzinke MA, Clarke W, Breaud A, Fiamma A, Donnell D, Kulich M, Mwambo JKK, Richter L, Gray G, Sweat M, Coates TJ, and Eshleman SH. Determination of HIV status in African adults with discordant HIV rapid tests. J AIDS. 2015; 69:430-438.
Eshleman SH, Hudelson SE, Redd AD, Swanstrom R, Ou S-S, Zhang XC, Ping L-H, Piwowar-Manning E, Porcella SF, Sievers MF, Martens CA, Bruno D, Dukhovlinova E, McCauley M, Gamble T, Fogel JM, Sabin D, Quinn TC, Gunde L, Maliwichi M, NhandoN, Akelo V, Panchia R, Kumarasamy N, Chotirosniramit N, de Melo MG, Pilott J, Grinsztejn B, Mayer K, Chen YQ, Hughes JP, Cohen MS. Treatment as Prevention: Characterization of partner infections in the HIV Prevention Trials Network 052 trial. J AIDS. 1/2017; 74:112-116 [PMC5140698].