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Jodi Beth Segal, M.D., M.P.H.
Co-Director, Center for Drug Safety and Effectiveness
Professor of Medicine
Expertise: Internal Medicine
Research Interests: Comparative effectiveness research; Pharmacoepidemiology; Evidence synthesis; High-value healthcare
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Dr. Jodi Segal is a professor of medicine at the Johns Hopkins University School of Medicine. She has joint appointments in health policy and management, and epidemiology at the Johns Hopkins Bloomberg School of Public Health. Dr. Segal is internationally recognized as a clinician-investigator in comparative effectiveness research and pharmacoepidemiology.
She serves as the associate director of the Center for Health Services and Outcomes Research (CHSOR) and the co-director of the Center for Drug Safety and Effectiveness (CDSE), both in the School of Public Health. Additionally, she’s the director of the Pharmacoepidemiology Program.
Dr. Segal received a B.S. from The Pennsylvania State University. She earned her M.D. from the University of Pittsburgh School of Medicine and her M.P.H. from the Johns Hopkins Bloomberg School of Public Health. She completed her residency at the University of Chicago and performed a fellowship in internal medicine at Johns Hopkins.
Her research interests include pharmacoepidemiology, comparative effectiveness research and evidence-based medicine. Dr. Segal and her team have been tapped by the Food and Drug Administration (FDA) to conduct research to find out why physicians opt to prescribe costlier brand-name drugs when generic ones are available.
She is on the Fellowship Advisory Committee at Johns Hopkins. She serves as the principal investigator of the Primary Care and Health Services Research Training Program. She is a member of Phi Beta Kappa and Alpha Omega Alpha.
- Co-Director, Center for Drug Safety and Effectiveness
- Associate Director, Center for Health Services and Outcomes Research
- Director, Pharmacoepidemiology Program
- Professor of Medicine
- MD, University of Pittsburgh School of Medicine (1994)
- The University of Chicago / Internal Medicine (1997)
- Johns Hopkins University School of Medicine / Internal Medicine (2000)
Research & Publications
Dr. Segal’s research interests include developing methodology to use observational data to understand the use of new drugs, particularly drugs for treatment of diabetes, blood disorders and osteoporosis. She is an experienced clinical epidemiologist and health services researcher with skills in applying advanced methods for evidence-based review and meta-analysis, and in collaboration with her colleagues in biostatistics, has developed new methodologies for observational research (using propensity scores to adjust for covariates which change over time) and methods to account for competing risks and heterogeneity of treatment effects in analyses.
Selected PublicationsView all on Pubmed
Romano MJ, Segal JB, Pollack CE. "The association between continuity of care and the overuse of medical procedures." JAMA Intern Med. 2015 Jul;175(7):1148-54.
Bridges JFP, Berger Z, Austin M, Nassery N, Sharma R, Chelladurai Y, Karmarkar TD, Segal JB. "Public reporting of cost measures in health: an environmental scan of current practices and assessment of consumer centeredness [Internet]." Rockville (MD): Agency for Healthcare Research and Quality (US); 2015 Mar.
Segal JB, Nassery N, Chang HY, Chang E, Chan K, Bridges JF. "An index for measuring overuse of health care resources with Medicare claims." Med Care. 2015 Mar;53(3):230-6.
Nassery N, Segal JB, Chang E, Bridges JF. "Systematic overuse of healthcare services: a conceptual model." Appl Health Econ Health Policy. 2015 Feb;13(1):1-6.
Segal JB, Maruthur NM. "Initial therapy for diabetes mellitus." JAMA Intern Med. 2014 Dec;174(12):1962-3.
Naik RP, Streiff MB, Haywood C Jr, Segal JB, Lanzkron S. "Venous thromboembolism incidence in the cooperative study of sickle cell disease." J Thromb Haemost. 2014 Dec;12(12):2010-6.
Huang YL, Moon J, Segal JB. "A comparison of active adverse event surveillance systems worldwide." Drug Saf. 2014 Aug;37(8):581-96.
Romanelli RJ, Segal JB. "Predictors of statin compliance after switching from branded to generic agents among managed-care beneficiaries." J Gen Intern Med. 2014 Oct;29(10):1372-8.
Schmittdiel JA, Raebel MA, Dyer W, Xu S, Goodrich GK, Schroeder EB, Segal JB, O' Connor PJ, Nichols GA, Lawrence JM, Kirchner HL, Karter AJ, Lafata JE, Butler MG, Steiner JF. "Prescription medication burden in patients with newly diagnosed diabetes: a SUrveillance, PREvention, and ManagEment of Diabetes Mellitus (SUPREME-DM) study." J Am Pharm Assoc (2003). 2014 Jul-Aug;54(4):374-82.
Romanelli RJ, Jukes T, Segal JB. "Compliance after switching from branded to generic statins." Pharmacoepidemiol Drug Saf. 2014 Oct;23(10):1093-100.
Segal JB, Bridges JF, Chang HY, Chang E, Nassery N, Weiner J, Chan KS. Identifying Possible Indicators of Systematic Overuse of Health Care Procedures With Claims Data. Med Care. 2013 Dec 26. [Epub ahead of print] PMID: 24374418
Raebel MA, Xu S, Goodrich GK, Schroeder EB, Schmittdiel JA, Segal JB, O'Connor PJ, Nichols GA, Lawrence JM, Kirchner HL, Elston Lafata J, Butler M, Newton KM, Steiner JF. Initial Antihyperglycemic Drug Therapy Among 241 327 Adults With Newly Identified Diabetes From 2005 Through 2010: A Surveillance, Prevention, and Management of Diabetes Mellitus (SUPREME-DM) Study. Ann Pharmacother. 2013 Oct;47(10):1280-91. doi: 10.1177/1060028013503624. PMID: 24259692
Haut ER, Garcia LJ, Shihab HM, Brotman DJ, Stevens KA, Sharma R, Chelladurai Y, Akande TO, Shermock KM, Kebede S, Segal JB, Singh S. The Effectiveness of Prophylactic Inferior Vena Cava Filters in Trauma Patients: A Systematic Review and Meta-analysis. JAMA Surg. 2013 Nov 6. doi: 10.1001/jamasurg.2013.3970. [Epub ahead of print] PMID: 24195920
Gudzune KA, Lau BD, Hutfless S, Boult C, Segal JB. Strategies To Prevent Weight Gain in Adults: Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 97 [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jun. PMID: 24027797
Wu Y, Lau BD, Bleich S, Cheskin L, Boult C, Segal JB, Wang Y. Future Research Needs for Childhood Obesity Prevention Programs: Identification of Future Research Needs From Comparative Effectiveness Review No. 115 [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 Jun. PMID: 24027795
Chang HY, Richards TM, Clark JM, Weiner JP, Segal JB. Change in claims-based diabetes medications is a diabetes improvement indicator. Am J Manag Care. 2013 Jul;19(7):572-8. PMID: 23919420 [PubMed - in process]
Singh S, Haut ER, Brotman DJ, Sharma R, Chelladurai Y, Shermock KM, Kebede S, Stevens KA, Prakasa KR, Shihab HM, Akande TO, Zeidan AM, Garcia LJ, Segal JB. Pharmacologic and Mechanical Prophylaxis of Venous Thromboembolism Among Special Populations [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2013 May. PMID: 23844446
Erekosima N, Suarez-Cuervo C, Ramanathan M, Kim JM, Chelladurai Y, Segal JB, Lin SY. Effectiveness of subcutaneous immunotherapy for allergic rhinoconjunctivitis and asthma: A Systematic Review. Laryngoscope. 2013 Jul 6. doi: 10.1002/lary.24295. [Epub ahead of print] PMID: 23832632
Chan KS, Chang E, Nassery N, Chang HY, Segal JB. The state of overuse measurement: a critical review. Med Care Res Rev. 2013 Oct;70(5):473-96. doi: 10.1177/1077558713492202. Epub 2013 Jun 26. PMID: 23804290
Snyder CF, Jensen RE, Segal JB, Wu AW. Patient-reported outcomes (PROs): putting the patient perspective in patient-centered outcomes research. Med Care. 2013 Aug;51(8 Suppl 3):S73-9. doi: 10.1097/MLR.0b013e31829b1d84. PMID: 23774513
Academic Affiliations & Courses
Courses and Syllabi
Introduction to Comparative Effectiveness and Outcomes Research
Activities & Honors
- Best Abstract (Measuring Safety, Quality and Value category), Academy Health Annual Research Meeting, 2015
- Phi Beta Kappa
- Alpha Omega Alpha
- Leadership Program for Women Faculty, Johns Hopkins, 2010
- Deputy Editor, Journal of General Internal Medicine, 2007
- Chair-Elect, Eastern Region of the American Federation for Medical Research (AFMR), 2007
- Fellowship Advisory Committee, Johns Hopkins Division of General Internal Medicine
- Principal Investigator, Primary Care and Health Services Research Training Program, Johns Hopkins Division of General Internal Medicine