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School of Medicine
Juan R Carhuapoma, M.D.
Associate Professor of Neurology
Languages: English, Spanish
Expertise: Acute Stroke Care, Carotid Artery Disease, Carotid Artery Stenosis, Cerebrovascular Diseases, Critical Care, Critical Care Medicine, Intracerebral Hemorrhage , Intracranial Hypertension, Ischemic Heart Disease, Moyamoya Disease, Stroke, Stroke Imaging, Stroke Prevention, Stroke Recovery, Stroke Rehabilitation, Subarachnoid Hemorrhage , Transient Ischemic Attack, Traumatic Brain Injury ...read more
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The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-955-7481
1800 Orleans St.
Sheikh Zayed Tower
Baltimore, MD 21287 map
Dr. Juan Carhuapoma is an associate professor of neurology, neurosurgery, and anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include critical care medicine, intracerebral and subarachnoid hemorrhage, and intracranial hypertension.
He earned his M.D. from the Programa Academico de Medicina. He completed his residency in neurology at Henry Ford Hospital and performed a fellowship in neurological critical care at Johns Hopkins.
Dr. Carhuapoma is a member of several professional associations, including the Neurocritical Care Society, the American Heart Association Stroke Council and the Society of Critical Care Medicine.
- Associate Professor of Neurology
- Associate Professor of Anesthesiology and Critical Care Medicine
- Associate Professor of Neurosurgery
Departments / Divisions
Centers & Institutes
- MD, Programa Academico De Medicina (1991)
- Henry Ford Hospital / Neurology (1997)
- Johns Hopkins University School of Medicine / Neurological Critical Care (1999)
Research & Publications
Dr. Carhuapoma’s overall research interests include three areas: (1) the role of pharmacologic neuroprotection of perihematoma tissue following intracerebral hemorrhage (ICH); (2) the different hemodynamic and metabolic aspects of neuronal blood flow and metabolism under physiologic conditions and after acute brain injury, as well as their significance in neurologic outcome; and (3) the use of advanced MRI techniques in the study and understanding of ongoing neuronal damage after brain injury to design and assess therapies used in neurologic critical care.
To investigate these areas, Dr. Carhuapoma is engaged in a number of studies. The first explores the safety and feasibility of thrombolysis with ultrasound in the treatment of ICH and intraventricular hemorrhage (known as the SLEUTH study).
In another study, Dr. Carhuapoma and his colleagues are investigating removal of an ICH with minimally invasive surgery and treatment with recombinant tissue plasminogen activator (rtPA). The goal of this study is to provide novel safety data that will change the way in which ICHs are treated, including previously unavailable data about the safety, efficacy, and pharmacokinetics of rtPA, as well as MIS data regarding the validity and safety of patient selection, quantitation of surgical effectiveness, patient stability, and disease/treatment-related complications. The study results also will provide the first estimates of the relationship between initial disease severity and long-term outcome for ICH. These data are critical to reducing brain injury from the only stroke subtype for which no adequate treatment is available.
In a study supported by the Food & Drug Administration, Dr. Carhuapoma and his colleagues are conducting a multicentered clinical trial of thrombolysis for intraventricular hemorrhage, the results of which will allow for the development of an effective treatment for intraventricular hemorrhage and demonstrate the safety and efficacy of thrombolysis with rtPA for that type of stroke.
Lab Website: Neurovascular Laboratory
Selected PublicationsView all on Pubmed
Barnes B, Hanley DF, Carhuapoma JR. "Minimally invasive surgery for intracerebral haemorrhage." Curr Opin Crit Care. 2014 February 16
Naval NS, Kowalski RG, Chang TR, Caserta F, Carhuapoma JR, Tamargo RJ. "The SAH Score: A comprehensive communication tool." J Stroke Cerebrovasc Dis. 2013 October 5
Chang TR, Kowalski RG, Caserta F, Carhuapoma JR, Tamargo RJ, Naval NS. "Impact of acute cocaine use on aneurysmal subarachnoid hemorrhage." Stroke. 2013 May 7
Mould WA, Carhuapoma JR (Mould and Carhuapoma contributed equally to this paper as first authors, as acknowledged in the publication), Muschelli J, Lane K, Morgan TC, McBee NA, Bistran-Hall AJ, Ullman NL, Vespa P, Martin NA, Awad I, Zuccarello M, Hanley DF, MISTIE Investigators. "Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema." Stroke. 2013 Mar;44(3):627-34
Kowalski RG, Chang TR, Carhuapoma JR, Tamargo RJ, Naval NS. "Withdrawal of technological life support following subarachnoid hemorrhage." Neurocrit Care. 2013; 19: 269-75
Activities & Honors
- Neurocritical Care Society
- American Heart Association Stroke Council
- Society of Critical Care Medicine
- Society of Neurosurgical Anesthesia and Critical Care
- American Academy of Neurology
- Neurocritical Care Society