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School of Medicine
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Chloe Lynne Thio, M.D.
Professor of Medicine
Specializes in: Adults (18+ years)
Expertise: Hepatitis, HIV/AIDS, Infectious Disease
Research Interests: Hepatitis B, hepatitis C, HIV
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The Johns Hopkins Hospital
Appointment Phone: 443-997-1900
600 N. Wolfe Street
Baltimore, MD 21287 map
Dr. Chloe Thio is a professor of medicine and an associate professor of molecular microbiology and immunology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include hepatitis, HIV/AIDS and infectious disease.
Dr. Thio received her B.A. from the University of Pennsylvania. She earned her M.D. from the Yale University School of Medicine. She completed her residency at Hospital of the University of Pennsylvania and performed a fellowship in infectious diseases at Johns Hopkins.
Her research interests include hepatitis and HIV/AIDS. Her recent research revealed that certain HIV drugs provide added benefit of protecting against hepatitis B.
Dr. Thio serves on the Promotions Committee for the Department of Medicine. She is a member of the American College of Physicians, the American Association for the Study of Liver Disease, the American Society of Clinical Investigation, HIVMA and the Infectious Diseases Society of America.
- Professor of Medicine
- MD, Yale University School of Medicine (1992)
- Hospital of the University of Pennsylvania - GME / Internal Medicine (1995)
- Johns Hopkins University School of Medicine / Infectious Diseases (2000)
Research & Publications
Dr. Thio has several research interests. Her laboratory is focused on hepatitis B translational science that is working towards a hepatitis B cure including HBV virology in single hepatocytes, immune response to acute hepatitis B, and neutralizing antibodies to hepatitis B.
Her laboratory also investigates the human genetic determinants of HBV and HCV clearance, where she examines polymorphisms in human genes in persons that have either recovered from or have a persistent viral hepatitis infection.
Her laboratory also studies fatty liver in people with HIV and HIV-hepatitis co-infection.
Thio CL, Guo N, Xie C, Nelson KE, Ehrhardt S. "Global elimination of mother-to-child transmission of hepatitis B: Revisiting the current strategy." The Lancet Infectious Diseases. 2015;15(8):981-985.
Falade-Nwulia O, Seaberg EC, Snider AE, Rinaldo CR, Phair P, Witt WD, Thio CL. Incident hepatitis B in HIV-infected and HIV-uninfected men who have sex with men from pre-HAART to HAART periods: a cohort study. Ann Int Med; 2015 Nov; 163(9):673-80. PMCID PMC4630157
Vergara C, Thio CL, Johnson E, Kral AH, O'Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH, Kirk GD, Kim AY, Lauer GM, Chung RT, Cox AL, Peters MG, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Busch MP, Alexander G, Rosen HR, Murphy EL, Latanich R, Wojcik GL, Taub MA, Valencia A, Thomas DL, Duggal P. Multi-ancestry genome-wide association study of spontaneous clearance of hepatitis C virus. Gastroenterology 2018 Dec, in press
Li Y, Xie J, Wang H, Han Y, Wang N, Li T*, Thio CL* (contributed equally). Elevated pre-treatment IL-18 level is associated with HBeAg seroconversion in HIV-HBV co-infection. Antiviral Therapy, 2017; 22(6):523-27
Price JC, Seaberg EC, Stosor V, Witt MD, Lellock CD, Thio CL. AST-to-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis coinfected men. AIDS 2018 Nov 32(17):2636-38.
Academic Affiliations & Courses
Graduate Program AffiliationMolecular Microbiology and Immunology
Activities & Honors
- American College of Physicians
- American Society of Clinical Investigation
- Infectious Diseases Society of America
- American Association for the Study of Liver Disease
- Promotions Committee, Johns Hopkins Department of Medicine, 2015