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Douglas Edward Gladstone, M.D.

Photo of Dr. Douglas Edward Gladstone, M.D.
  • Director, Clinical Services, Division of Hematologic Malignancies/Bone Marrow Transplant Program
  • Associate Professor of Oncology
Male

Expertise

Allogeneic Bone Marrow Transplantation, Autologous Blood and Marrow Transplant, Chronic Lymphoblastic Leukemia, Hairy Cell Leukemia (HCL), Hodgkin's Disease, Non-Hodgkin's Lymphoma (NHL) ...read more

Research Interests

Immunologic and Non-Chemotherapeutic Treatment Straggles to Treat Hematologic Malignancies

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Insurance Information

Maryland

410-955-8964

Outside of Maryland

410-464-6641
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International Patients

+1-410-502-7683
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Locations

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964
401 N. Broadway
Baltimore, MD 21231 map

The Bunting Blaustein Cancer Research Building

1650 Orleans Street
Baltimore, MD 21287 map

Background

Dr. Douglas Gladstone is an Oncologist in Baltimore caring for patients with leukemias and lymphomas; he is recognized nationally as an expert in the care of patients with these disorders.  Dr. Gladstone serves as the clinical director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins outpatient blood and marrow program.  

Dr. Gladstone received his undergraduate degree in Biology from SUNY Binghamton (Binghamton, NY), earned his M.D. at the New York School of Medicine (NY, NY), completed his Residency at Strong Memorial Hospital of the University of Rochester (Rochester, NY), and Fellowship in Medical Oncology at Johns Hopkins (Baltimore, MD). Dr. Gladstone joined the Johns Hopkins faculty in 2009 after co-directing the blood and marrow transplant program at SUNY Stony Brook (Stony Brook, NY).

His main research interests adopting immunologic and non-chemotherapeutic treatment straggles to treat hematologic malignancies.  In 2018, he helped Moextumomab pasudotox obtain FDA approval for refractory Hairy CelL Leukemia, the first FDA approved for HCL in decades. Currently, Dr. Gladstone, is leading a national trial of cord blood derived immunotherapy to treat COVID-19 patients. 

Dr. Gladstone has a passion for teaching trainees and has taught at Johns Hopkins, medical students, residents and fellows and received numerous teaching awards and accolades.

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Titles

  • Director, Clinical Services, Division of Hematologic Malignancies/Bone Marrow Transplant Program
  • Associate Professor of Oncology

Departments / Divisions

Centers & Institutes

Education

Degrees

  • MD, New York University School of Medicine (1992)

Residencies

  • Strong Memorial Hospital of the University of Rochester / Internal Medicine (1996)

Fellowships

  • Johns Hopkins University School of Medicine / Hematology and Oncology (1999)

Board Certifications

  • American Board of Internal Medicine / Medical Oncology (1999)

Research & Publications

Research Summary

Dr. Douglas Gladstone is an Oncologist in Baltimore caring for patients with leukemias and lymphomas; he is recognized nationally as an expert in the care of patients with these disorders.  Dr. Gladstone serves as the clinical director of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins outpatient blood and marrow program. 

Clinical Trial Keywords

Hodgkin’s Lymphoma, Non-Hodgkin’s Lymphoma, CLL, HCL, Allogeneic Bone and Marrow Transplantation, DSA

Selected Publications

View all on Pubmed

Gladstone DE, Kim BS, Mooney K, Karaba AH, D'Alessio FR. Regulatory T Cells for Treating Patients With COVID-19 and Acute Respiratory Distress Syndrome: Two Case Reports. Ann Intern Med. 2020 Jul 6:L20-0681. Online ahead of print. PMID: 32628535

Paul S, Zahurak M, Luznik L, Ambinder RF, Fuchs EJ, Bolaños-Meade J, Wagner-Johnston N, Swinnen LJ, Schoch L, Varadhan R, Jones RJ, Gladstone DE Non-Myeloablative Allogeneic Transplantation with Post-Transplant Cyclophosphamide after Immune Checkpoint Inhibition for Classic Hodgkin Lymphoma: A Retrospective Cohort Study. Biol Blood Marrow Transplant. 2020 Jun 24:S1083-8791(20)30367-0. PMID: 32592857

Paul S, Tsai HL, Lowery P, Fuchs EJ, Luznik L, Bolaños-Meade J, Swinnen LJ, Shanbhag S, Wagner-Johnston N, Varadhan R, Ambinder RF, Jones RJ, Gladstone DE. Allogeneic Haploidentical Blood or Marrow Transplantation with Post-Transplantation Cyclophosphamide in Chronic Lymphocytic Leukemia. Biol Blood Marrow Transplant. 2020 Mar;26(3):502-508. Epub 2019 Nov 12. PMID: 31730920

Schoch LK, Asiama A, Zahurak M, Shanbhag S, Hunt J, Sawyer K, Swinnen LJ, Wagner-Johnston N, Jones RJ, Ambinder RF, Gladstone DE. Pharmacokinetically-targeted dosed everolimus maintenance therapy in lymphoma patients. Cancer Chemother Pharmacol. 2018 Feb;81(2):347-354. PMID: 29234922

Kreitman RJ, Dearden C, Zinzani PL, Delgado J, Karlin L, Robak T, Gladstone DE, le Coultre P, Dietrich S, Gotic M, Larratt L, Offner F, Schiller G, Swords R, Bacon L, Bocchia M, Bouabdallah K, Breems DA, Cortelezzi A, Dinner S, Doubek M, Gjertsen BT, Gobbi M, Hellmann A, Lepretre S, Maloisel F, Ravandi F, Rousselot P, Rummel M, Siddigi T, Tadmor T, Troussard X, Yi CA, Saglio G, Roboz GJ, Balic K, Standifer N, He P, Marshall S, Wison W, Pastan l, Yao NS, Giles F. Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia. Leukemia 2018 Aug;32(8):1768-1777.

Activities & Honors

Honors

  • Phi Beta Kappa, 1988
  • Inducted into the Drexel University 106 Club Invited, 2001
  • Certificate of Appreciation for Excellence in Training Resident Physicians, Stony University Medical Center, 2005
  • Certificate of Appreciation for Excellence in Training Resident Physicians, Stony University Medical Center, 2006
  • Director’s Teaching Award in Clinical Science, Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, 2011
  • National Expert in Chronic Lymphocytic Leukemia- CLL Society, 2018
  • National Expert in Hairy Cell Leukemia – Hairy Cell Leukemia Foundation, 2019

Memberships

  • American College of Physicians, 1993
  • American Society of Hematology, 1997
  • Eastern Cooperative Oncology Group Member, 1999
  • American Society of Clinical Oncology, 2014

Professional Activities

  • Diplomate, Hematology, 2001
  • Co-Director, Blood and Marrow Transplant Program, SUNY Stony Brook Medicine, NY, 2009
  • Leukemia Core Committee Member, Eastern Cooperative Oncology Group, 2011
  • Director, Clinical Services, Division of Hematologic Malignancies/Bone Marrow Transplant Program, 2010
  • Committee Member, Hematologic Oncology/Infectious Diseases, 2010

Videos & Media

Recent News Articles and Media Coverage

Hairy Cell Leukemia: Addressing Unmet Clinical Needs, Podcast

Patient Ratings & Comments

The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

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