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School of Medicine
Argye Hillis, M.D.
Argye Elizabeth Hillis, M.D.
Director, Center of Excellence in Stroke Detection and Diagnosis
Professor of Neurology
Expertise: Aphasia, Apraxia, Cortical Visual and Perceptual Impairments, Corticobasal Degeneration, Dementia, Neurology, Speech and Language Impairments, Stroke ...read more
Research Interests: Stroke Cognitive Outcome and Recovery (SCORE); Language Recovery After Stroke; Cognitive Deficits and Recovery after Right Hemisphere Stroke ...read more
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The Johns Hopkins Hospital
Appointment Phone: 410-614-2381
600 N. Wolfe Street
Phipps Suite 446
Baltimore, MD 21287 map
Johns Hopkins Outpatient Center
Appointment Phone: 410-614-2381
601 N. Caroline St.
Baltimore, MD 21287 map
Johns Hopkins Medicine - Green Spring Station
10751 Falls Road
Falls Concourse Suite 250
Lutherville, MD 21093 map
Dr. Argye Hillis is a professor of Neurology, with joint faculty appointments in Physical Medicine and Rehabilitation and in Cognitive Science.
Prior to medical training and neurology residency, Dr. Hillis worked as a speech-language pathologist, and conducted clinical research focusing on understanding and treating aphasia and hemispatial neglect. She has brought these areas of experience to impact on her clinical research in neurology, which involves cognitive and neuroimaging studies of aphasia and hemispatial neglect due to acute stroke and focal dementias. She has published extensively on these topics in journals and textbooks.
Dr. Hillis is Associate Editor of Stroke and has served as Associate editor of Brain, Annals of Neurology, Aphasiology, American Journal of Speech-Language Pathology, Neurocase, Cognitive Neuropsychology, and Language and Cognitive Processes and served as co-Editor and Chief of Behavioral Neurology.
Dr. Hillis serves as the Executive Vice Chair of the Department of Neurology and the Director of the Cerebrovascular Division of Neurology at Johns Hopkins.
- Director, Center of Excellence in Stroke Detection and Diagnosis
- Director, Cerebrovascular Division of Neurology
- Executive Vice Chair, Department of Neurology
- Professor of Neurology
- Professor of Physical Medicine and Rehabilitation
Centers & Institutes
- MD; Medicine, Johns Hopkins University School of Medicine (1995)
- Johns Hopkins University School of Medicine / Neurology (1999)
- American Board of Psychiatry & Neurology / Neurology (2001)
Research & Publications
Following a stroke, an individual may experience speech, language, cognitive, or emotional problems. Dr. Hillis’ current research aims to improve the understanding of how language and other cognitive functions are represented and carried out in the brain, how they recover after injury, and how understanding these processes can contribute to evaluation and treatment of stroke and dementia. Specifically, current research studies include the following:
- Stroke Cognitive Outcome and Recovery (SCORE)
- Language Recovery After Stroke
- Cognitive Deficits and Recovery after Right Hemisphere Stroke
Dr. Hillis' current research combines longitudinal task-related and task-free functional imaging and structural imaging from the acute stage of stroke through the first year of recovery, with detailed cognitive and language assessments to improve our understanding how language and other cognitive functions recover after stroke. Her other avenue of research involves novel treatment studies and longitudinal imaging and language studies of Primary Progressive Aphasia. She has published extensively on these topics in journals and textbooks.
Lab Website: S.C.O.R.E. Lab
Selected PublicationsView all on Pubmed
SELECTED PUBLICATIONS (from >150 total)
Hillis, A.E. (1989). Efficacy and generalization of treatment for aphasic naming errors. Archives of Physical Medicine and Rehabilitation, 70, 632-636.
Caramazza, A. & Hillis, A.E. (1991). Lexical organization of nouns and verbs in the brain. Nature, 349,788-90.
Hillis, A.E. & Caramazza, A. (1991). Category-specific naming and comprehension impairment: A double dissociation. Brain, 114, 2081-2094.
Hillis, A.E. & Caramazza, A. (1995). Cognitive and neural mechanisms underlying visual and semantic processing. Journal of Cognitive Neuroscience, 7, 457-478.
Hillis, A.E. & Caramazza, A. (1995). The representation of grammatical categories of words in the brain. Journal of Cognitive Neuroscience, 7, 396-407.
Hillis, A.E., Boatman, D., Hart, J. & Gordon, B. (1999). Making sense out of jargon: a neurolinguistic and computational account of jargon aphasia. Neurology, 53, 1813-1824.
Hillis, A.E., Wityk, R.J., Tuffiash, E., Beauchamp, N.J., Jacobs, M.A., Barker, P.B., Selnes, O.A. (2001). Hypoperfusion of Wernickes area predicts severity of semantic deficit in acute stroke. Annals of Neurology, 50, 561-566.
Hillis, A.E., Wityk, R.J., Barker, P.B., Beauchamp, N.J., Gailloud, P., Murphy, K., Cooper, O., Metter, E.J. (2002). Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion, Brain,125, 1094-1104.
Hillis, A.E., Tuffiash, E. & Caramazza, A. (2002). Modality specific deterioration in oral naming of verbs. Journal of Cognitive Neuroscience, 14, 1099-1108.
Hillis, A.E., Wityk, R., Barker, P.B., Caramazza, A. (2003). Neural regions essential for writing verbs. Nature Neuroscience, 6, 19-20.
Hillis, A.E., Oh, S., Ken, L. (2004). Deterioration of naming nouns versus verbs in primary progressive aphasia. Annals of Neurology, 55, 268-275.
Hillis, A.E., Work, M., Breese, E.L., Barker, P.B., Jacobs, M.A. & Maurer, K. (2004). Re-examining the brain regions crucial for orchestrating speech articulation. Brain, 127, 1479-1487.
Hillis, A.E., Newhart, M., Heidler, J., Barker, P.B., Herskovits, E., and Degaonkar, M. (2005). The roles of the visual word form area in reading. NeuroImage, 24, 548-559.
Reineck, L., Agarwal, S. & Hillis, A.E. (2005). The diffusion-clinical mismatch predicts early language recovery in acute stroke. Neurology, 64, 828-833.
Hillis, A.E., Newhart, M., Heidler, J., Barker, P.B., Degaonkar, M. (2005). Anatomy of spatial attention: insights from perfusion imaging and hemispatial neglect in acute stroke. Journal of Neuroscience, 25, 3161-7.
Charles, R. & Hillis, A.E. (2005). Posterior Cortical Atrophy: clinical presentation and cognitive deficits compared to Alzheimers Disease. Behavioural Neurology, 16, 15-23.
Hillis, A.E., Heidler-Gary, J., Newhart, M., Chang, S., Ken, L. & Bak, T. (2006). Naming and comprehension in primary progressive aphasia: the influence of grammatical word class. Aphasiology, 20, 246-256.
Newhart, M., Ken, L., Kleinman, J.T., Heidler-Gary, J., & Hillis, A.E. (2007). Neural networks essential for naming and word comprehension. Cognitive and Behavioral Neurology, 20, 25-30.
DeLeon, J., Gottesman, R.F., Kleinman, J.T., Newhart, M., Davis, C., Lee, A., Hillis, A.E. (2007) Neural regions essential for distinct cognitive processes underlying picture naming. Brain, 130, 1408-22.
Heidler-Gary, J. & Hillis, A.E. (2007). Distinctions between the dementia in Amyotrophic Lateral Sclerosis with Frontotemporal Dementia and the dementia of Alzheimer''s Disease. Amyotrophic Lateral Sclerosis.
Philipose, L.E., Gottesman, R.F., Newhart, M.; Kleinman, J.T.; Herskovits, E.H.; Pawlak, M.A., Marsh, E.B.; Davis, C.; Heidler-Gary, J.; Hillis, A.E. (2008). Neural regions essential for reading and spelling of words and pseudowords. Annals of Neurology. 481-492.
Cloutman, L., Gottesman, R., Chaudhry, P., Davis, C., Kleinman, J.T., Pawlak, M., Herskovits, E.H., Kannan, V., Lee, A., Newhart, M., Heidler-Gary, J., Hillis, A.E. (2008)Where (in the brain) do semantic errors come from? Cortex. [Epub ahead of print]
Medina, J., Kannan, V., Pawlak, M., Kleinman, J.T., Newhart, M., Davis, C., Heidler-Gary J.E., Herskovits,
E.H., Hillis, A.E. (2008) Neural substrates of visuospatial processing in distinct reference frames: evidence from unilateral spatial neglect. Journal of Cognitive Neuroscience. [Epub ahead of print].
Cloutman, L., Gingis, L., Newhart, M., Davis, C., Heidler-Gary, J., Crinion, J., Hillis, A.E. (in press). A neural
network critical for spelling. Annals of Neurology.
Activities & Honors
- Alpha Omega Alpha
- Phi Beta Kappa
- Research Fellow, National Stroke Association
- Fellow, American Heart Association
- Fellow, American Stroke Association
- Derek Denny-Brown Neurological Scholar Award, American Neurological Association
- Norman Geschwind Award in Behavioral Neurology, American Academy of Neurology
- Best Doctors in America, 2014
- Baltimore Top Docs 2015, Baltimore Magazine, 2015
- Academy of Aphasia
- American Academy of Neurology
Section on Behavioral Neurology
- American Heart Association Stroke Council
Fellow;Abstract Reviewer for the International Stroke Conference (2003-2007); Scientific Session Chair, 2005, 2006
- American Neurological Association
Scientific Program Committee (2004-2006)
- Clinical Aphasiology Conference
Program committee 1985, 1992; Program Chair 2003; Conference Chair 2004; Steering Committee (2003-present)
- Faculty 1000 Medicine
- Society for Neuroscience
- World Federation of Neurology- Research Group on Aphasia and Cognitive Disorders
- American Speech Language Association, 2015
Advances in Diagnosis, Treatment, and Prognosis of Primary Progressive Aphasia
Videos & Media
Recent News Articles and Media Coverage
Dr. Argye Hillis is among a group from around the country that will use an $11 million National Institute of Health grant to study if electrical brain stimulation and other therapies can help stroke victims recover language skills. Baltimore Sun (04/21/2016)
Argye Hillis Among Stoke Researchers Awarded $11 Million NIH Grant Press Release (4/20/16)
Dealing with the emotional aspects of stroke rehab, Philadelphia Inquirer (04/13/2014)
For our bodies we have gyms, and for our minds we have...brain fitness apps, ComputerWorld (01/13/2014)
Why You Get the Joke: Brain's Sarcasm Center Found, Live Science